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28 Possible Causes for Edema of the Hands and Feet, Thick Facial Skin, Weight Gain

  • Acromegaly

    We report the case of a 43 years old patient initially diagnosed with acromegaly accompanied by weight gain and acral enlargement.[] The facial aspect is characteristic and includes a widened and thickened nose, prominent cheekbones, forehead bulges, thick lips and marked facial lines.[] Dermal glycosaminoglycan accumulation and edema cause skin distention that is most prominent in the face, hands, and feet.[]

  • Erythropoietic Protoporphyria

    Credit: Wikimedia Commons Harlequin ichthyosis is a severe genetic disorder that results in thick skin spotted with deep cracks.[] Prolonged exposure to the sun can lead to edema of the hands, face, and feet, rarely with blistering and petechiae. Skin thickening can sometimes occur over time.[] These skin abnormalities affect the shape of facial features and limit arm and leg movement.[]

  • Secondary Hypothyroidism

    Total weight gain at this point is 50 pounds, I exercise, and eat a disgustingly healthy diet.[] […] speech 91 Eyelid edema 90 Cold sensation 89 Decreased sweating 89 Cold skin 83 Thick tongue 82 Facial edema 79 Coarse hair 76 Skin pallor 67 Forgetfulness 66 Constipation[] Myxedema usually appears in the later stages if not treated resulting in nonpitting edema present around the eyes, hands, and feet.[]

  • Myxedema Coma

    […] expression, dementia or frank psychosis (myxedema madness) Dermatologic manifestations: Facial puffiness; myxedema; sparse, coarse and dry hair; coarse, dry, scaly and thick[] It is also possible to observe signs of periorbital and non-pitting edema on hands and feet, as well as enlarged tonsils, facial swelling, and thinning of hair.[] Patients with hypothyroidism typically have a history of fatigue, weight gain, constipation and cold intolerance.[]

  • Gonadotropic Pituitary Adenoma

    Too much of this hormone causes weight gain, particularly in the body’s trunk.[] Change in facial structure — jaw and brow may stick out and the nose, tongue, and lips may get bigger. Skin becoming thick, coarse, and oily.[] Further, TS patients may also present with a webbed neck, edema of the hands and feet, congenital heart disease, hypothyroidism, and/or a shield shaped chest.[]

  • Noonan Syndrome

    Although PTPN11 mutation, greater gestational age, and cardiac surgery also had a negative effect on weight gain and length in the study, the investigators found that at age[] They can also present with thick hooded eyelids, wrinkled skin and a high anterior hair line, albeit all aforementioned facial features can be subtle.[] Intrauterine findings Lymphatic dysfunction Polyhydramnios Nuchal translucency Prefrontal edema Hydrothorax Lymphedema of the hands and feet at birth Normal karyotype Physical[]

  • Disproportionate Short Stature - Ptosis - Valvular Heart Lesions

    […] features with thick lips (6) Loose skin (7) HRAS mutations 4.[] Karyotype should be considered in “any female with unexplained growth failure or pubertal delay or any constellation of the following clinical findings: edema of the hands[] Low birth-weight / slow weight gain Most children with Williams syndrome have a slightly lower birth-weight than their brothers or sisters.[]

  • Gigantism - Acromegaly

    gain by mid-childhood.[] Serious physiological symptoms also may appear, such as increased sweating, thick and coarse oily skin, and chronic sinus congestion.[] Physical examination showed coarse facial features, spade-like hands and feet, pitting pedal edema, galactorrhoea, and features of congestive cardiac failure.[]

  • Acromegaly - Cutis verticis gyrata - Corneal Leukoma Syndrome

    Two patients died in the immediate postoperative period, and 10 patients received radiotherapy with “reversal of their diencephalic syndrome” (weight gain, deposition of subcutaneous[] Upon examination, he was a well-built muscular male with coarse facial features with broadening of the nasal bridge and thick lips.[] There was obvious bilateral clubbing of all digits on the hands and feet as well as nonpitting edema and tenderness of the bilateral knee, tarsalmetatarsal and interphalangeal[]

  • SHOX-Related Short Stature

    The most common presenting symptom is an insidious weight gain with lack of height gain.[] Characteristic facial features include broad, high forehead; hypertelorism; micrognathia; low-set, posteriorly rotated ears with a thick helix; high-arched eyebrows; short[] Karyotype should be considered in “any female with unexplained growth failure or pubertal delay or any constellation of the following clinical findings: edema of the hands[]

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