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108 Possible Causes for Elevated Sedimentation Rate, Normocytic Normochromic Anemia, Splenomegaly

  • Rheumatoid Arthritis

    A normochromic (or slightly hypochromic)-normocytic anemia occurs in 80%; Hb is usually 10 g/dL.[merckmanuals.com] It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] In a patient with inflammatory arthritis, the presence of a rheumatoid factor or anti-citrullinated protein antibody, or elevated C-reactive protein level or erythrocyte sedimentation[ncbi.nlm.nih.gov]

  • Hodgkin's Disease

    The presenting feature common in all cases was superficial lymphadenopathy followed by hepatomegaly in 17 (20%) cases and splenomegaly in 16 (19%).[ncbi.nlm.nih.gov] Abdomen: Abdominal enlargement may be noted with splenomegaly or hepatomegaly.[symptoma.com] Hodgkin's lymphoma symptoms include night sweats, enlarged lymph nodes, splenomegaly, and back pain. Treatment entails radiotherapy or chemotherapy.[medscape.org]

  • Pediatric Chronic Granulomatous Disease

    Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, cytopenias, splenomegaly, and hemophagocytosis by macrophages activated by high cytokine levels.[ncbi.nlm.nih.gov] The erythrocyte sedimentation rate might be elevated in some patients. Hypergammaglobulinemia is commonly seen in patients with chronic granulomatous disease.[lecturio.com] DANGER SIGNS: failure to thrive, inflammatory anemia, thrombocytopenia, splenomegaly, lymphadenopathy, joint swelling/bone pain, dysmorphia, recurrent serious infections,[hawaii.edu]

  • Subphrenic Abscess

    She also had splenomegaly. Salmonella enteritidis serotype Heidelberg was isolated by thoracentesis.[ncbi.nlm.nih.gov] The erythrocyte sedimentation rate (ESR) is commonly elevated. Liver function tests are helpful.[es.slideshare.net] Of them, 13 patients had massive splenomegaly and six had moderate splenomegaly.[ejs.eg.net]

  • Waldenstrom Macroglobulinemia

    Laboratory tests A complete blood count in WM exhibits leukopenia, normocytic normochromic anemia, and thrombocytopenia.[symptoma.com] Abstract Manifestations of macroglobulinemic lymphoma include lymphadenopathy, splenomegaly and bone marrow involvement.[ncbi.nlm.nih.gov] […] erythrocyte sedimentation rate.[ncbi.nlm.nih.gov]

  • Infective Endocarditis

    Established infections often cause a normocytic-normochromic anemia, elevated WBC count, increased ESR, increased immunoglobulin levels, and the presence of circulating immune[merckmanuals.com] This score includes clinical, epidemiological (male, fever, splenomegaly, clubbing, vascular disease and stroke) and biological criteria (Leucocytes 10,000/mm3, sedimentation[ncbi.nlm.nih.gov] […] erythrocyte sedimentation rate, elevated C-reactive protein level, as well as the presence of central nonfeeding lines, peripheral lines, and microscopic hematuria [ 14 ][doi.org]

  • Bacterial Endocarditis

    Established infections often cause a normocytic-normochromic anemia, elevated WBC count, increased ESR, increased immunoglobulin levels, and the presence of circulating immune[merckmanuals.com] The condition is characterized by heart murmur, prolonged fever, bacteremia, splenomegaly, and embolic phenomena.[medical-dictionary.thefreedictionary.com] Blood tests show signs of inflammation such as an elevated sedimentation rate,while anemia and blood cells in the urine are often present.[csun.edu]

  • Subacute Bacterial Endocarditis

    normocytic anemia is usual, while neutrophil leucocytosis is common ESR: may be raised Renal and liver function test: levels of creatinine may be raised; levels of liver[pathologyoutlines.com] Fever, anaemia, splenomegaly and positive blood cultures for Gram-negative bacteria were found on admission.[ncbi.nlm.nih.gov] Laboratory abnormalities included anemia, elevated erythrocyte sedimentation rate, positive rheumatoid factor, positive anticardiolipin antibody, positive lupus anticoagulant[ncbi.nlm.nih.gov]

  • Anemia of Infection

    Anemia in ART-naïve HIV patients was mostly normocytic, normochromic and characterized by a normal or low reticulocyte index suggesting 'anemia of chronic disease' as the[bmcinfectdis.biomedcentral.com] This may occur particularly in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency (see Chap. 46 ), splenomegaly (see Chap. 55 ), and in the microvascular[mhmedical.com] Clinical Manifestation • Variable - Incubation 3-100 weeks • Lowgrade fever • Hepato-splenomegaly • Bone marrow hyperplasia • Anemia, Leucopenia & Cachexia • Hypergammaglobulinnemia[slideshare.net]

  • Adult-Onset Still Disease

    Complete blood cell count Leukocytosis with predominant granulocytes, normocytic, normochromic anemia of chronic disease and reactive thrombocytosis are typical.[clinicaladvisor.com] […] clinically by high spiking fever, polyarthralgia/arthritis, a salmon-pink evanescent rash, predominantly neutrophilic leucocytosis, lymphadenopathy, liver dysfunction, and splenomegaly[ncbi.nlm.nih.gov] The two most commonly associated with AOSD are an elevated sedimentation rate (ESR) and a high blood ferritin level.[thedoctorwillseeyounow.com]

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