Elongated Palpebral Fissures: Causes & Reasons

Possible Causes for Elongated Palpebral Fissures

(The typical facial features: elongated palpebral fissures with eversion of the lateral third of the lower eyelid; arched and broad eyebrows; short columella with depressed [flipper.diff.org]

Cranio-facial features include elongated palpebral fissures with eversion of the lateral third of the lower eyelid; arched and broad eyebrows with the lateral third displaying [orpha.net]

palpebral fissures that are often accompanied by eversion of the lower lid (particularly the lateral third), and a depressed nasal tip. [symptoma.com]

Molybdenum Cofactor Deficiency Type B

NM_176806.3(MOCS2):c.*266_*269delGTCA AND Molybdenum cofactor deficiency, complementation group B Significance: Pathogenic ClinVar: RCV000006484 Variant: NM_176806.3(MOCS2):c.*266_*269delGTCA Type: Variant Allele: NM_176806.3(MOCS2):c.*266_*269delGTCA 21149 Gene: MOCS2 Type: Deletion Location: Chr5: 52397217 -[…] [gepedia.com]

Molybdenum Cofactor Deficiency Type A

Résumé Les maladies héréditaires du métabolisme (MHM) résultent le plus souvent d’un déficit enzymatique sur l’une des nombreuses voies métaboliques, dérivées des glucides, protides ou acides gras ou du trafic intracellulaire Preview Unable to display preview. Download preview PDF. Références Scriver CR, Beaudet AL,[…] [link.springer.com]

Euryblepharon

CLINICAL CHARACTERISTICS In euryblepharon the palpebral fissure is elongated horizontally. [mhealthknowledge.org]

Euryblepharon presents with Bilateral symmetrical enlargement of the horizontal palpebral apertures. Elongated lid margins. [aimu.us]

It has been suggested that euryblepharon results from a developmental hypoplasia or absence of the palpebral and lacrimal portions of the orbicularis muscle. [mhealthknowledge.org]

Kabuki Syndrome Type 2

KS does not have a predominance of ethnicity, age, or sex.2,3 This syndrome is characterized by dysmorphic facial features, such as elongated palpebral fissures with eversion [dovepress.com]

Physical examination showed bilateral iris coloboma, right microphthalmia, inverse epicanthus, elongated palpebral fissures that inclined upwards, eversion of the lateral [dovepress.com]

Typical dysmorphic features, such as elongated palpebral fissures, arched eyebrows, a short columella with a sunken nasal tip (Figure 1A and B), and persistent finger pads [dovepress.com]

Teebi-Naguib-Al Awadi Syndrome

Clinical description Dysmorphic features include triangular or elongated face, hypertelorism, wide palpebral fissures, short, stubby nose with anteverted nostrils, long philtrum [orpha.net]

The consistent features were a triangular or elongated face, telecanthus or mild hypertelorism, wide palpebral fissures without ptosis, short stubby nose with anteverted nostrils [cags.org.ae]

Congenital Symmetric Circumferential Skin Creases

[…] face, high forehead, blepharophimosis, short palpebral fissures, microphthalmia, microcornea, epicanthic folds, telecanthus, microtia, posteriorly angulated ears, broad nasal [orpha.net]

Craniofacial anomalies included: an elongated face, tight forehead, hypertelorism, bilateral epicanthic folds, upslanting palpebral fissures, microphthalmia, convergent strabismus [hero.epa.gov]

[…] by severe psychomotor delay, intellectual disability, congenital, symmetrical circumferential skin creases of arms and legs, cleft palate, and facial dysmorphism (incl. elongated [orpha.net]

Paralytic Lagophthalmos

The palpebral opening decreased 2 to 3 mm in all cases. 23 patients showed a significant improvement of the ocular symptoms. 3 patients whose palpebral fissure could not be [medigraphic.com]

[…] closed long enough to protect their eyeballs required a further elongation of the graft of the ear cartilage of 4 mm and a lateral tarsorrhaphy. [medigraphic.com]

Deficiency of Sulfite Oxidase

The majority of patients exhibit facial dysmorphism (prominent forehead, narrow bifrontal diameter, sunken eyes, elongated palpebral fissures, puffy cheeks, small nose and [orpha.net]

These facial differences include a relatively long and narrow face; deep-set, widely-spaced eyes; elongated openings of the eyes (palpebral fissures); puffy cheeks; a small [ghr.nlm.nih.gov]

Hardikar Syndrome

Cranio-facial features include elongated palpebral fissures with eversion of the lateral third of the lower eyelid; arched and broad eyebrows with the lateral third displaying [orpha.net]

Typical facial features include elongated palpebral fissures with eversion of the lateral third of the lower eyelid, arched and broad eyebrows with the lateral third displaying [blueprintgenetics.com]

Trisomy 5p13.3

A Front view: large, round, elongated face; small, upslanting palpebral fissures; hypertelorism; epicanthus; bushy eyebrows; large nostrils, and thick lower lip vermillion [library.nih.go.kr]

[…] deep-set eyes with short palpebral fissures; obesity (BMI 37), and a neuropsychiatric disorder with high-functioning autism. [x-mol.com]

//www.karger.com/CGR Abstract A 17-year-old girl presented with a distinct phenotype mainly featuring craniofacial dysmorphism, including a disproportioned large, round, elongated [karger.com]

Femoral Hypoplasia

fissures, shortened nose, blunt alae nasi, elongated philtrum, and a thin upper lip. [ncbi.nlm.nih.gov]

[…] palate and antimongolian slant of palpebral fissure. [ncbi.nlm.nih.gov]

[…] philtrum, thin upper lip, microg-nathia, upslanting palpebral fissure, cleft palate and ear deformities) that also has similarities with the caudal regression syndrome (Daentl [rrnursingschool.biz]

Distal Trisomy 2p

Her face is elongated, the nose is bulbous with a broad bridge, and the palate is high and arched. Her palpebral fissures are of normal length (3.1/2.9 cm). [jmg.bmj.com]

Aughton Syndrome

Typical facial features : Elongated palpebral fissures with eversion of the lateral third of the lower eyelid; arched and broad eyebrows with the lateral third displaying [en.wikipedia.org]

Fetal Alcohol Syndrome

and narrow palpebral fissures, as well as absence or dysplasia of two or more nails. [ncbi.nlm.nih.gov]

Ample evidence shows that ethanol causes the "classic" fetal alcohol syndrome (FAS) face (short palpebral fissures, elongated upper lip, deficient philtrum) because it suppresses [ncbi.nlm.nih.gov]

fissures, epicanthal folds, a small or flat midface, a flat elongated philtrum, a thin upper lip, and a small chin. [msdmanuals.com]

7q11.23 Duplication Syndrome

Facial features: Recurring facial features included macrocephaly (3/8), prominent forehead (6/8), elongated palpebral fissures (7/10). [mdpi.com]

palpebral fissures, thin lip vermilion and microstomia. [mdpi.com]

Note macrocephaly, prominent forehead in some patients, elongated palpebral fissures, deep set eyes, palpebral ptosis, high prominent nasal bridge with bulbous nasal tip, [mdpi.com]

Waaler-Aarskog Syndrome

On extraoral examination, triangular-elongated face, widow’s peak, puffy enlarged lips, ocular hypertelorism, ptosis, slight antimongoloid obliquity of palpebral fissure, [peertechzpublications.com]

Figure 3: Showing triangular-elongated face, widow’s peak, puffy enlarged lips, ocular hypertelorism, ptosis, slight antimongoloid obliquity of palpebral fissure, small and [peertechzpublications.com]

Baraitser-Winter Syndrome

palpebral fissures, mouth corners directed down, face becoming less round and more elongated, and unilateral ptosis; at age 2 years 2 months: high forehead with frontal bossing [mdpi.com]

palpebral fissures, short nose, mouth corners directed down, round face); (d) 2 years and 2 months old (high forehead and frontal bossing); (e) 4 years old (unilateral ptosis [mdpi.com]

[…] short nose and round face; at age 8 months: small chin, retrognathia and posteriorly rotated ears; at age 12 months: progressive and more pronounced arching of the eyebrows, elongated [mdpi.com]

Autosomal Recessive Deafness 84B

upslanted palpebral fissures, persistent long philtrum with a thin vermilion border of the upper lip in a cohort of seven patients with GLIS3 mutations. [interactive-biosoftware.com]

Balasubramanian and colleagues report a study that describes the common facial dysmorphism consisting of bilateral low-set ears, depressed nasal bridge with overhanging columella, elongated [interactive-biosoftware.com]

Growth Delay-Hydrocephaly-Lung Hypoplasia Syndrome

The characteristic craniofacial dysmorphia is present in 100% of the cases and gives the patient a highly evocative appearance with elongated palpebral fissures with eversion [omicsonline.org]

Monosomy 2pter-p24

fissures, deep-set eyes, flat nasal bridge, midface hypoplasia, elongated philtrum, pointed chin, hypotonic face, low-set malformed and posterior rotated ears. [ncbi.nlm.nih.gov]

[…] affected patients show a peculiar phenotype consisting in microcephaly, brachycephaly, large and late-closing anterior fontanels, prominent forehead, straight eyebrows, short palpebral [ncbi.nlm.nih.gov]

Naguib Syndrome

Clinical description Dysmorphic features include triangular or elongated face, hypertelorism, wide palpebral fissures, short, stubby nose with anteverted nostrils, long philtrum [orpha.net]

Autosomal Dominant Aarskog-Scott Syndrome

Ring Chromosome 11 Syndrome

She had scaphocephaly and microcephalic, low-set ears, elongated face, short palpebral fissures, prominent nasal bridge, micrognathia, high palate, and short neck on physical [wjpch.com]

Morphologic features of ring chromosome 14 included scaphocephaly, microcephalic low-set ears, elongated face, short palpebral fissures, prominent nasal bridge, micrognathia [wjpch.com]

[…] face, short palpebral fissures, prominent nasal bridge, micrognathia, high palate, and short neck. [wjpch.com]

Kaufman Oculocerebrofacial Syndrome

With advancing age, the shape of the face became more elongated, the palpebral fissures became up-slanting and, in some patients the lip vermilion became more everted. [docksci.com]

*With age, the face becomes more elongated, the zygomata become flatter and the palpebral fissures more upslanted, and the alae nasi thicken [ Basel-Vanagaite et al 2014 ] [ncbi.nlm.nih.gov]

Camera-Marugo-Cohen Syndrome

[…] and sparse eyebrows, short palpebral fissures, microstomia, and high and narrow palate. [accessanesthesiology.mhmedical.com]

Simosa Penchaszadeh Bustos Syndrome (Simosa Craniofacial Syndrome; Blepharophimosis Telecanthus Microstomia Syndrome): High forehead, elongated and flattened face, arched [accessanesthesiology.mhmedical.com]

Osteoporosis-Oculocutaneous Hypopigmentation Syndrome

[…] philtrum more Head And Neck Eyes: blepharophimosis short palpebral fissures (in some patients) Head And Neck Ears: small ears Cardiovascular Heart: ventricular septal defect [malacards.org]

Manifestations Placenta And Umbilical Cord: placental abnormality (in some patients) Head And Neck Face: micrognathia retrognathia hairy forehead prominent or protruding philtrum elongated [malacards.org]

Multiple Congenital Anomalies

Kohlschütter-Tönz Syndrome

upslanted palpebral fissures, persistent long philtrum with a thin vermilion border of the upper lip in a cohort of seven patients with GLIS3 mutations. [interactive-biosoftware.com]

Exfoliative Ichthyosis

palpebral fissures, mild hypertelorism, flat, broad nasal root, small fontanels, small chin), as well as palmoplantar keratoderma and ichthyosis. [bredagenetics.com]

The syndrome also includes microcephaly, severe neurologic impairment, failure to thrive with psychomotor retardation, and facial dysmorphism (elongated facies, downward-slanting [bredagenetics.com]