Elongated Palpebral Fissures Causes & Reasons

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Elongated Palpebral Fissures Symptom Checker: Possible causes include Kabuki Syndrome. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Kabuki Syndrome

palpebral fissures that are often accompanied by eversion of the lower lid (particularly the lateral third), and a depressed nasal tip. [symptoma.com]

(The typical facial features: elongated palpebral fissures with eversion of the lateral third of the lower eyelid; arched and broad eyebrows; short columella with depressed [flipper.diff.org]

Cranio-facial features include elongated palpebral fissures with eversion of the lateral third of the lower eyelid; arched and broad eyebrows with the lateral third displaying [orpha.net]

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Deficiency of Sulfite Oxidase

The majority of patients exhibit facial dysmorphism (prominent forehead, narrow bifrontal diameter, sunken eyes, elongated palpebral fissures, puffy cheeks, small nose and [orpha.net]

palpebral fissures, puffy cheeks, small nose, long philtrum, and thick lips ( Figure 1 ) [ Salih et al 2013, Bosley et al 2014 ] Lens subluxation or dislocation (ectopia [ncbi.nlm.nih.gov]

These facial differences include a relatively long and narrow face; deep-set, widely-spaced eyes; elongated openings of the eyes (palpebral fissures); puffy cheeks; a small [ghr.nlm.nih.gov]

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Femoral Hypoplasia

fissures, shortened nose, blunt alae nasi, elongated philtrum, and a thin upper lip. [ncbi.nlm.nih.gov]

[…] palate and antimongolian slant of palpebral fissure. [ncbi.nlm.nih.gov]

[…] philtrum, thin upper lip, microg-nathia, upslanting palpebral fissure, cleft palate and ear deformities) that also has similarities with the caudal regression syndrome (Daentl [rrnursingschool.biz]

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Kohlschütter-Tönz Syndrome

upslanted palpebral fissures, persistent long philtrum with a thin vermilion border of the upper lip in a cohort of seven patients with GLIS3 mutations. [interactive-biosoftware.com]

Balasubramanian and colleagues report a study that describes the common facial dysmorphism consisting of bilateral low-set ears, depressed nasal bridge with overhanging columella, elongated [interactive-biosoftware.com]

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Microcytic Anemia

His facial features included an elongated face, short up-slanted palpebral fissures, bilateral epicanthal folds, long eyelashes, anteverted nares, long prominent philtrum, [nature.com]

[…] face, bilateral epicanthal folds, short up-slanted palpebral fissures, long eyelashes, anteverted nares, long prominent philtrum, thin upper lip and a short neck. ( h–k ) [nature.com]

[…] and weight with relatively short arms, and a pectus excavatum. ( f, g ) Frontal and lateral views of patient 3 at birth ( f ) and at 3 years and 10 months ( g ) showing an elongated [nature.com]

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Growth Delay-Hydrocephaly-Lung Hypoplasia Syndrome

The characteristic craniofacial dysmorphia is present in 100% of the cases and gives the patient a highly evocative appearance with elongated palpebral fissures with eversion [omicsonline.org]

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Autosomal Recessive Deafness 84B

upslanted palpebral fissures, persistent long philtrum with a thin vermilion border of the upper lip in a cohort of seven patients with GLIS3 mutations. [interactive-biosoftware.com]

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Familial Spontaneous Pneumothorax

palpebral fissures, long ears, and sagging cheeks. 10, 11 Bicuspid aortic valve with thoracic aortic aneurysm Bicuspid aortic valve (BAV) with thoracic aortic aneurysm (TAA [nature.com]

Characteristic facial features can include a distinctive elongated facies, micrognathia, small mouth, high arched palate, low set ears, long philtrum, beaked nose, down-slanting [nature.com]

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Arterial Tortuosity Syndrome

[…] ears, down-slanting palpebral fissures, high nasal bridge. [ojrd.biomedcentral.com]

[…] face, micrognathia, mild blepharophimosis, downslanting palpebral fissures, beaked nose, high-arched palate. iii) Patient 2 showed elongated face, low-set and anteverted [ojrd.biomedcentral.com]

[…] left common carotid and left subclavian arteries, ectasia of the innominate artery origin, and bilateral reduction of peripheral pulmonary branches. ii) Patient 1 showed elongated [ojrd.biomedcentral.com]

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Molybdenum Cofactor Deficiency Type B

NM_176806.3(MOCS2):c.*266_*269delGTCA AND Molybdenum cofactor deficiency, complementation group B Significance: Pathogenic ClinVar: RCV000006484 Variant: NM_176806.3(MOCS2):c.*266_*269delGTCA Type: Variant Allele: NM_176806.3(MOCS2):c.*266_*269delGTCA 21149 Gene: MOCS2 Type: Deletion Location: Chr5: 52397217 -[…] [gepedia.com]

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Molybdenum Cofactor Deficiency Type A

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Cutis Laxa

Patients present with an elongated face, slight hypertelorism, downslanting palpebral fissures, a beaked nose, and a rather long philtrum. [cmgg.be]

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Teratoma

[…] of the palpebral fissure, abscense of communication between the cyst and the intracranial cavity, normally developed eye that may exhibit degenerative changes secondary to [scielo.org.co]

palpebral fissure, normally developed eye that may exhibit degenerative changes secondary to the displacement by the teratoma, and transillumination of all or part of the [eyewiki.aao.org]

[…] clinical features of these tumors include an otherwise healthy newborn with extreme unilateral proptosis, marked stretching of the eyelids over a tense, fluctuating mass, elongation [scielo.org.co]

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Micrognathism

[…] facies (in newborns it is usually rounded), palpebral fissures, divergent strabismus, flat nasal bridge, and repetitive respiratory infections 3. [scielo.br]

Symptoms INHERITANCE: Autosomal recessive HEAD AND NECK: [Face]; Long face; Long philtrum; Micrognathia ; [Eyes]; Downslanting palpebral fissures; Blepharophimosis; Hypertelorism [findzebra.com]

[…] hypertonicity, scoliosis, flatfoot, facial asymmetry and laxity (maintaining an open mouth with protrusion of the tongue), prominent orbital arch, poor dental occlusion, elongated [scielo.br]

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Fetal Alcohol Syndrome

and narrow palpebral fissures, as well as absence or dysplasia of two or more nails. [ncbi.nlm.nih.gov]

Ample evidence shows that ethanol causes the "classic" fetal alcohol syndrome (FAS) face (short palpebral fissures, elongated upper lip, deficient philtrum) because it suppresses [ncbi.nlm.nih.gov]

fissures, epicanthal folds, a small or flat midface, a flat elongated philtrum, a thin upper lip, and a small chin. [msdmanuals.com]

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Kaufman Oculocerebrofacial Syndrome

With advancing age, the shape of the face became more elongated, the palpebral fissures became up-slanting and, in some patients the lip vermilion became more everted. [docksci.com]

*With age, the face becomes more elongated, the zygomata become flatter and the palpebral fissures more upslanted, and the alae nasi thicken [ Basel-Vanagaite et al 2014 ] [ncbi.nlm.nih.gov]

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Ductus Arteriosus Aneurysm

palpebral fissures, long ears, and sagging cheeks. 10, 11 Bicuspid aortic valve with thoracic aortic aneurysm Bicuspid aortic valve (BAV) with thoracic aortic aneurysm (TAA [nature.com]

Characteristic facial features can include a distinctive elongated facies, micrognathia, small mouth, high arched palate, low set ears, long philtrum, beaked nose, down-slanting [nature.com]

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Coffin-Lowry Syndrome

fissures, hypertelorism, blepharoptosis, large and prominent ears, large nose with broad base and elongated philtrum, mandibular prognathism, maxillary/midfacial hypoplasia [accessanesthesiology.mhmedical.com]

[…] calvarium, small sinuses paranasales, flat occiput, delayed suture closure with large anterior fontanelle, prominent supraorbital ridges with bushy brows, downwardly slanted palpebral [accessanesthesiology.mhmedical.com]

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Humero-Radial Synostosis

fissures, elongated nose with flattened nasal bridge, and thick lips), resulting from mutation in the transcription factor TFAP2B on chromosome 6p12-p21 (Char 1978; Sweeney [rrnursingschool.biz]

[…] fingers has been reported in the Char syndrome (OMIM 169100), a familial association of patent ductus arteriosus and unusual facies (high forehead, flat profile, downturned palpebral [rrnursingschool.biz]

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Multiple Congenital Anomalies

Craniofacial anomalies included: an elongated face, tight forehead, hypertelorism, bilateral epicanthic folds, upslanting palpebral fissures, microphthalmia, convergent strabismus [ncbi.nlm.nih.gov]

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King Syndrome

Our first examination at 6 years of age revealed elongated face with marked ptosis, down-slanting palpebral fissures, hypertelorism, epicanthic folds, low-set ears, malar [zdoc.site]

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Blepharophimosis

Our first step was to perform a lateral canthotomy of 5 mm to elongate the narrow horizontal palpebral fissure. [nature.com]

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Sotos Syndrome

In childhood, the facies are characterized by an elongated head, macrodolichocephaly, frontal bossing, hypertelorism, downward slanting palpebral fissures, pointed jaw, and [symptoma.com]

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Mitochondrial DNA Depletion Syndrome

Patients may display variable facial dysmorphia such as a narrow elongated face, protruding malformed ears, epicanthal folds and downslanting palpebral fissures of the eyes [cags.org.ae]

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Mega-Cisterna Magna

palpebral fissures and late-onset lens dislocation.1,2,5 In addition, they have thickened lips and broad philtrum, thick cheeks, small nose and microcephaly.2,5,6 They usually [dovepress.com]

[…] of life and an atypical one characterized by a late onset.4,6,12,13 In the classical variant, patients manifest a crude facial phenotype with depressed hyperteloric eyes, elongated [dovepress.com]

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Nemaline Myopathy Type 4

Dysmorphic craniofacial features include progressive microcephaly, flat occiput, widened inner canthal distance, small palpebral fissures, ptosis, long and straight eyelashes [panelapp.genomicsengland.co.uk]

broad and high nasal root extending to a widened, prominent nasal tip with elongated, smooth philtrum, rounding of the upper vermillion border and everted lower lips. [panelapp.genomicsengland.co.uk]

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Intestinal Pseudo-Obstruction - Patent Ductus Arteriosus - Natal Teeth

With time, the face elongates, the palpebral fissures slant downward due to the relative lesser growth of the zygoma, the nose profile becomes more convex, the columella hangs [docplayer.net]

Newborns often show a full, edematous face, unusual dark hair, upward slanting of the palpebral fissures, a nose without the low hanging columella, a full lower lip, and slight [docplayer.net]

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Ocular Albinism

We describe a boy with an interstitial deletion of 6(q13-q15) and include "coarse" facial features, upslanting palpebral fissures, thin vermilion border of the upper lip, [ncbi.nlm.nih.gov]

fissures, thin vermilion border of the upper lip, elongated philtrum, developmental delay, and profound hypotonia. [onlinelibrary.wiley.com]

elongated philtrum, developmental delay, and profound hypotonia. [ncbi.nlm.nih.gov]

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Lenz-Majewski Syndrome

fissures, elongated nose with flattened nasal bridge, and thick lips), resulting from mutation in the transcription factor TFAP2B on chromosome 6p12-p21 (Char 1978; Sweeney [rrnursingschool.biz]

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Distal Symphalangism

fissures, elongated nose with flattened nasal bridge, and thick lips), resulting from mutation in the transcription factor TFAP2B on chromosome 6p12-p21 (Char 1978; Sweeney [rrnursingschool.biz]

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