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1,887 Possible Causes for EMG Shows Evidence of Reinnervation, Muscle Biopsy Abnormal, Respiratory Muscle Weakness

  • Duchenne Muscular Dystrophy

    Diagnosis of Duchenne Muscular Dystrophy A muscle biopsy (taking a sample of muscle) for dystrophin studies can be done to look for abnormal levels of dystrophin in the muscle[disabled-world.com] In this context, the most frequent respiratory complication is nocturnal and daytime hypoventilation related to respiratory muscle weakness.[ncbi.nlm.nih.gov] […] fibers) For Duchenne and Becker muscular dystrophies, muscle biopsy may show whether dystrophin, a muscle protein, is missing or abnormal, and DNA testing is used to analyze[webmd.com]

    Missing: EMG Shows Evidence of Reinnervation
  • Amyotrophic Lateral Sclerosis

    Only about 10% of ALS patients have abnormal nerve conduction study results, but the test can also suggest other diagnoses. A muscle biopsy.[webmd.com] Respiratory muscle weakness and failure is a common complication late in the course of disease.[ncbi.nlm.nih.gov] Weekly data downloads showed that disease progression was associated with increased respiratory muscle weakness, decreased spontaneous breathing, and increased use of non-invasive[ncbi.nlm.nih.gov]

    Missing: EMG Shows Evidence of Reinnervation
  • Becker Muscular Dystrophy

    Electromyography was abnormal in all patients. Muscle biopsy in 1 patient demonstrated normal immunostaining for dystrophin.[ncbi.nlm.nih.gov] Our cases became unable to walk in their teens, and were introduced to mechanical ventilation due to respiratory muscle weakness in their twenties and thirties.[ncbi.nlm.nih.gov] Elevated serum CK Skeletal muscle biopsy showing decreased dystrophin quantity Panel overlap The gene on this panel is also included on our Autism Intellectual Disability[unmc.edu]

    Missing: EMG Shows Evidence of Reinnervation
  • Polymyositis

    Muscle biopsy abnormalities at some time during their disease: i. degeneration and regeneration of muscle fibers ii. necrosis iii. phagocytosis iv. interstitial mononuclear[clinicaltrials.gov] Dysphagia and neck flexor weakness can develop along with respiratory muscle weakness as the disease progresses.[ncbi.nlm.nih.gov] Laboratory testing showed elevated muscle enzymes and myopathic abnormalities on electromyographic examination.[ncbi.nlm.nih.gov]

    Missing: EMG Shows Evidence of Reinnervation
  • Glycogen Storage Disease Type 2

    Autophagy in Pompe mouse models The morphological evidence for abnormal autophagy in muscle biopsies from adult Pompe patients was first reported by Andrew Engel in 1970 ([ncbi.nlm.nih.gov] Some patients have presented with pulmonary (lung) insufficiency due to respiratory muscle weakness.[web.archive.org] A muscle tissue biopsy may be assayed for muscle glycogen phosphorylase enzyme activity.[encyclopedia.com]

    Missing: EMG Shows Evidence of Reinnervation
  • Dermatomyositis

    Muscle biopsy abnormalities at some time during their disease: i. degeneration and regeneration of muscle fibers ii. necrosis iii. phagocytosis iv. interstitial mononuclear[clinicaltrials.gov] , dysphonia, dysphagia Less common: respiratory muscle weakness, visual changes, abdominal pain Systemic complications/association: Cardiomyopathy Cardiac conduction defects[physio-pedia.com] Muscle biopsy abnormalities at some time during their disease: Muscle fiber destruction; Muscle fiber regeneration; Perivascular and interstitial inflammatory infiltrates[clinicaltrials.gov]

    Missing: EMG Shows Evidence of Reinnervation
  • Spinal Muscular Atrophy

    Muscle biopsies showed typical signs of neurogenic damage. Molecular genetic analysis showed mutations of the ASAH1 gene.[ncbi.nlm.nih.gov] Progressive respiratory muscle weakness with bulbar involvement is the main cause of morbidity and mortality in type I and severe type II spinal muscular atrophy.[ncbi.nlm.nih.gov] They have extremely weak muscle tone (hypotonia) at birth. Their respiratory muscles are very weak and they often do not survive past infancy due to respiratory failure.[ghr.nlm.nih.gov]

    Missing: EMG Shows Evidence of Reinnervation
  • Motor Neuron Disease

    For patients with MND affecting the LMNs, the EMG will show evidence of: (1) acute denervation, which is ongoing as motor neurons degenerate, and (2) chronic denervation and[en.wikipedia.org] The results of electromyography and muscle biopsy were compatible with ALS. However, supranuclear vertical gaze palsy and slow saccades are seen.[ncbi.nlm.nih.gov] Breathing difficulties As MND progresses, respiratory muscle weakness will affect most people with the condition.[hse.ie]

  • Spinal Muscular Atrophy Type 1

    They have extremely weak muscle tone (hypotonia) at birth. Their respiratory muscles are very weak and they often do not survive past infancy due to respiratory failure.[ghr.nlm.nih.gov] Patients with DSMA1 present between 6 weeks and 6 months of age with progressive muscle weakness and respiratory failure due to diaphragmatic palsy.[ncbi.nlm.nih.gov] SMA also weakens the chest cavity muscles, which produces a weak cough. Children with type 1 find it difficult to breath normally and fight off respiratory infections.[stopsma.org]

    Missing: EMG Shows Evidence of Reinnervation
  • Muscular Dystrophy

    This condition is typically characterized by large and abnormally distributed mitochondria on muscle biopsy, which can distinguish this condition from the other muscle conditions[ncbi.nlm.nih.gov] Some patients may need assisted ventilation to treat respiratory muscle weakness and a pacemaker for cardiac abnormalities.[ninds.nih.gov] Under the microscope, the muscle of a positive biopsy generally shows dead tissue and abnormally large muscle fibers.[cedars-sinai.edu]

    Missing: EMG Shows Evidence of Reinnervation

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