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394 Possible Causes for Enlarged Cytoplasmic Vacuoles in Bone, Muscle, and Brain Tissue

Did you mean: Enlarged, Cytoplasmic Vacuoles, in Bone, Muscle, and Brain Tissue

  • Cardiomyopathy

    Cardiomyopathy affects the heart muscle itself. “Cardio” means heart and “myopathy” means muscle disease. There are several types of cardiomyopathy.[bostonscientific.com] The mechanism of myocardial injury is related to degeneration and atrophy of myocardial cells, with loss of myofibrils and cytoplasmic vacuolization.[emedicine.medscape.com] Inflammation that takes place in other tissues can be extremely serious, especially within the brain. Vasculitis is caused by inflammation of the blood vessel walls.[resources.lupus.org]

  • Leiomyosarcoma

    vacuoles at both ends of nuclei (unlike neural lesions) Mitotic figures are common May have hemangiopericytoma-like vasculature, nuclear palisading, myxoid change, osteoclast-like[pathologyoutlines.com] […] of Muscle Clinical Examination of Leiomyosarcoma of Muscle How is Leiomyosarcoma of Muscle Diagnosed?[healthengine.com.au] Soft tissue sarcoma brain metastases. Prevalence in a cohort of 3829 patients. Cancer. 2002;94(10):2706-11. Isobe N, Oki S, Sumida M, et al.[jneurology.com]

  • Intestinal Pseudo-Obstruction

    vacuoles, marked nuclear enlargement and irregularity and interstitial fibrosis ( Am J Surg Pathol 1987;11:846 ) May have segmental hypoganglionosis at transitional zone[pathologyoutlines.com] The present findings indicate a specific defect of colonic smooth muscle cells likely related to an ineffective response to acetylcholine.[ncbi.nlm.nih.gov] The tissues and organs that require the greatest amount of energy – such as the muscles, heart, brain, optic nerves, liver and gastrointestinal (GI) tract – are generally[em-consulte.com]

  • Amyotrophic Lateral Sclerosis

    Cytoplasmic vacuoles were found in the remaining anterior horn motor neurons of the lumbar spinal cord.[ncbi.nlm.nih.gov] In this review, we summarize how the expression of some microRNAs is dysregulated in the skeletal muscle of ALS mouse models and patients.[ncbi.nlm.nih.gov] Finally, proteomic analyses of brain tissue demonstrated the occurrence of several fungal peptides.[ncbi.nlm.nih.gov]

  • Inclusion Body Myositis

    Sporadic inclusion-body myositis (s-IBM) is the most common degenerative muscle disease in which aging appears to be a key risk factor.[ncbi.nlm.nih.gov] Cytoplasmic vacuolation. Characteristic tubo-filamentous inclusions within the cytoplasm and nuclei of muscle cells.[patient.info] Could findings of similar deposits in brain and muscle tissue explain this increase?[ncbi.nlm.nih.gov]

  • Kernicterus

    […] decreased muscle tone Opisthotonos is caused by spasm of muscles along the spinal column.[g6pddf.org] In the cytoplasm of the same large neurons, elaborate myelin figures surrounded tongues of cytoplasm, vacuoles and degenerative elements.[ncbi.nlm.nih.gov] Kernicterus, severe brain damage caused by an abnormal concentration of the bile pigment bilirubin in brain tissues at or shortly after birth.[britannica.com]

  • Pleomorphic Rhabdomyosarcoma

    […] showing smooth-muscle and fibrohistiocytic differentiation.[ncbi.nlm.nih.gov] vacuoles that distended the cells in such a way that often no other cytoplasm was evident.[jpma.org.pk] Breast Head & Neck Mediastinum Peritoneum Genitourinary Lymph Node/Spleen Hematopathology Gynecologic Orthopedic Endocrine Skin Gastrointestinal Soft Tissue Fibrous Tissue[webpathology.com]

  • Danon Disease

    The purpose of this investigation was to quantify functional performance, muscle weakness, and quadriceps activation in individuals with Danon disease as compared with healthy[ncbi.nlm.nih.gov] However, the first muscle biopsy with large cytoplasmic vacuoles confused the diagnosis and led to the second biopsy that allowed for the final diagnosis.[ncbi.nlm.nih.gov] LAMP2 b is expressed most prominently in muscle and brain, and LAMP2 a is expressed in greatest quantity in other tissues.[flipper.diff.org]

  • Guillain-Barré Syndrome

    Incorporation of sucrose into lysosomes causes swelling of epithelial cells and cytoplasmic vacuolization of the tubules, especially in the proximal tubules.[karger.com] Visser, The electrophysiological muscle scan, Muscle & Nerve, 36, 4, (436-446), (2007).[dx.doi.org] Older formulations of rabies vaccine cultured in mammalian brain tissues have been found to have an increased risk of GBS, but newer formulations of rabies vaccine, derived[dx.doi.org]

  • Lafora Disease

    Vacuoles: Subsarcolemmal; Some rimmed Internal nuclei Inclusions: Desmin Polyglucosan bodies Phosphoglucomutase 1 Deficiency (GSD 14) Phosphoglucomutase 1 (PGM1) ; Chromosome[neuromuscular.wustl.edu] In nonneural tissues, periodic acid-Schiff (PAS)-positive polyglucosan bodies were observed in the heart, skeletal muscle, liver, apocrine sweat gland, and smooth muscle layer[ncbi.nlm.nih.gov] Similar results were obtained in brain tissue samples from transgenic mice deficient in either the EPM2A or EPM2B genes.[ncbi.nlm.nih.gov]

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