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394 Possible Causes for Enlarged Cytoplasmic Vacuoles in Bone, Muscle, and Brain Tissue

Did you mean: Enlarged, Cytoplasmic Vacuoles, in Bone, Muscle, and Brain Tissue

  • Cardiomyopathy

    Cardiomyopathy affects the heart muscle itself. “Cardio” means heart and “myopathy” means muscle disease. There are several types of cardiomyopathy.[] The mechanism of myocardial injury is related to degeneration and atrophy of myocardial cells, with loss of myofibrils and cytoplasmic vacuolization.[] Inflammation that takes place in other tissues can be extremely serious, especially within the brain. Vasculitis is caused by inflammation of the blood vessel walls.[]

  • Leiomyosarcoma

    vacuoles at both ends of nuclei (unlike neural lesions) Mitotic figures are common May have hemangiopericytoma-like vasculature, nuclear palisading, myxoid change, osteoclast-like[] […] of Muscle Clinical Examination of Leiomyosarcoma of Muscle How is Leiomyosarcoma of Muscle Diagnosed?[] Soft tissue sarcoma brain metastases. Prevalence in a cohort of 3829 patients. Cancer. 2002;94(10):2706-11. Isobe N, Oki S, Sumida M, et al.[]

  • Intestinal Pseudo-Obstruction

    vacuoles, marked nuclear enlargement and irregularity and interstitial fibrosis ( Am J Surg Pathol 1987;11:846 ) May have segmental hypoganglionosis at transitional zone[] The present findings indicate a specific defect of colonic smooth muscle cells likely related to an ineffective response to acetylcholine.[] The tissues and organs that require the greatest amount of energy – such as the muscles, heart, brain, optic nerves, liver and gastrointestinal (GI) tract – are generally[]

  • Amyotrophic Lateral Sclerosis

    Cytoplasmic vacuoles were found in the remaining anterior horn motor neurons of the lumbar spinal cord.[] In this review, we summarize how the expression of some microRNAs is dysregulated in the skeletal muscle of ALS mouse models and patients.[] Finally, proteomic analyses of brain tissue demonstrated the occurrence of several fungal peptides.[]

  • Inclusion Body Myositis

    Sporadic inclusion-body myositis (s-IBM) is the most common degenerative muscle disease in which aging appears to be a key risk factor.[] Cytoplasmic vacuolation. Characteristic tubo-filamentous inclusions within the cytoplasm and nuclei of muscle cells.[] Could findings of similar deposits in brain and muscle tissue explain this increase?[]

  • Kernicterus

    […] decreased muscle tone Opisthotonos is caused by spasm of muscles along the spinal column.[] In the cytoplasm of the same large neurons, elaborate myelin figures surrounded tongues of cytoplasm, vacuoles and degenerative elements.[] Kernicterus, severe brain damage caused by an abnormal concentration of the bile pigment bilirubin in brain tissues at or shortly after birth.[]

  • Pleomorphic Rhabdomyosarcoma

    […] showing smooth-muscle and fibrohistiocytic differentiation.[] vacuoles that distended the cells in such a way that often no other cytoplasm was evident.[] Breast Head & Neck Mediastinum Peritoneum Genitourinary Lymph Node/Spleen Hematopathology Gynecologic Orthopedic Endocrine Skin Gastrointestinal Soft Tissue Fibrous Tissue[]

  • Danon Disease

    The purpose of this investigation was to quantify functional performance, muscle weakness, and quadriceps activation in individuals with Danon disease as compared with healthy[] However, the first muscle biopsy with large cytoplasmic vacuoles confused the diagnosis and led to the second biopsy that allowed for the final diagnosis.[] LAMP2 b is expressed most prominently in muscle and brain, and LAMP2 a is expressed in greatest quantity in other tissues.[]

  • Guillain-Barré Syndrome

    Incorporation of sucrose into lysosomes causes swelling of epithelial cells and cytoplasmic vacuolization of the tubules, especially in the proximal tubules.[] Visser, The electrophysiological muscle scan, Muscle & Nerve, 36, 4, (436-446), (2007).[] Older formulations of rabies vaccine cultured in mammalian brain tissues have been found to have an increased risk of GBS, but newer formulations of rabies vaccine, derived[]

  • Lafora Disease

    Vacuoles: Subsarcolemmal; Some rimmed Internal nuclei Inclusions: Desmin Polyglucosan bodies Phosphoglucomutase 1 Deficiency (GSD 14) Phosphoglucomutase 1 (PGM1) ; Chromosome[] In nonneural tissues, periodic acid-Schiff (PAS)-positive polyglucosan bodies were observed in the heart, skeletal muscle, liver, apocrine sweat gland, and smooth muscle layer[] Similar results were obtained in brain tissue samples from transgenic mice deficient in either the EPM2A or EPM2B genes.[]

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