Enlargement of the Liver: Causes & Reasons

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Possible Causes for Enlargement of the Liver

Gaucher Disease

People in this group usually bruise easily due to low blood platelets and experience fatigue due to anemia They also may have an enlarged liver and spleen. [ninds.nih.gov]

[britannica.com] Enlargement of the Liver Type 1 Gaucher disease (GD1) is characterized by thrombocytopenia, anemia, an enlarged spleen, and liver as well as bone complications [symptoma.com]

Type 1 Gaucher disease (GD1) is characterized by thrombocytopenia, anemia, an enlarged spleen, and liver as well as bone complications (Erlenmeyer flask deformity, osteoporosis [ncbi.nlm.nih.gov]

Niemann-Pick Disease Type C

The disease primarily affects the: liver spleen brain bone marrow This leads to enlargement of the spleen and neurologic problems. [healthline.com]

liver or spleen. [healthline.com]

The signs and symptoms of type B may include: swelling of the abdomen from enlargement of the liver and spleen, which often begins in early childhood respiratory infections [healthline.com]

Mucopolysaccharidosis Type 3

Patients with MPS 7 may have abnormal coarsened facial features, enlargement of the liver and spleen, airway obstruction, lung disease, cardiovascular complications, joint [ultragenyx.com]

Additional findings include short stature, heart abnormalities, breathing irregularities, liver and spleen enlargement (hepatosplenomegaly), and/or neurological abnormalities [rarediseases.org]

Although the clinical features of the disease are mainly neurological, patients may also develop diarrhea, carious teeth, and an enlarged liver and spleen. [checkorphan.org]

Mucopolysaccharidosis Type 1

Additional findings include short stature, heart abnormalities, breathing irregularities, liver and spleen enlargement (hepatosplenomegaly), and/or neurological abnormalities [rarediseases.org]

Enlargement of the liver and spleen. [rarediseases.org]

Affected individuals may develop coarse facial features, joint stiffness, short stature, clouding of the corneas, abnormally enlarged liver and/spleen (hepatosplenomegaly) [rarediseases.org]

Chronic Lymphocytic Leukemia

[…] nodes; stage II, lymphocytosis with enlarged spleen or liver or both; stage III, lymphocytosis with anemia; and stage IV:lymphocytosis with thrombocytopenia. [ncbi.nlm.nih.gov]

The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia. [ncbi.nlm.nih.gov]

Chronic lymphoblastic leukemias (CLL) often cause an enlargement of the liver and spleen. [youtube.com]

Mucopolysaccharidosis

[…] of the liver and spleen and decreased range of motion and mobility. [efpia.eu]

Symptoms include dwarfism, severe bone disease, including facial deformity, degenerative joint disease, enlarged liver and eye cloudiness. [vetgen.com]

Additional findings include short stature, heart abnormalities, breathing irregularities, liver and spleen enlargement (hepatosplenomegaly), and/or neurological abnormalities [rarediseases.org]

Lipodystrophy

Children can also develop periorbital edema (swelling around the eye sockets), and edema (clubbing) of finger and/or toes, and gradual enlargement of the liver, along with [autoinflammatory.org]

There may be abnormal breakdown of fats with loss of weight, excessive levels of fats in the blood, raised blood sugar levels, enlargement of the liver and abnormal thyroid [medical-dictionary.thefreedictionary.com]

This condition results in enlargement of the liver and kidneys. [epainassist.com]

Cytomegalovirus Infection

[…] of the liver and spleen with jaundice, to stillbirth or neonatal/infant death. [ideas.health.vic.gov.au]

[…] spleen and liver, jaundice, and a rash caused by bleeding underneath the skin. [babycenter.com]

The following potential problems can occur for infants who are infected from their mothers before birth (during pregnancy): Moderate enlargement of the liver and spleen, small [americanpregnancy.org]

Primary Hyperoxaluria Type 1

[counsyl.com] Insoluble calcium deposits in other body tissues can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver [symptoma.com]

Insoluble calcium deposits in other body tissues can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver and spleen; and [myriadwomenshealth.com]

[…] spleen or liver skin problems, including livedo reticularis, rash, necrosis, and gangrene of the hands and feet Primary hyperoxaluria is a rare genetic disorder that can [healthline.com]

Primary Hyperoxaluria Type 3

[counsyl.com] Insoluble calcium deposits in other body tissues can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver [symptoma.com]

This can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver and spleen; and problems with the electrical system of the [nxgenmdx.com]

Primary Hyperoxaluria Type 2

[counsyl.com] Insoluble calcium deposits in other body tissues can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver [symptoma.com]

[…] spleen or liver skin problems, including livedo reticularis, rash, necrosis, and gangrene of the hands and feet Primary hyperoxaluria is a rare genetic disorder that can [healthline.com]

Primary Hyperoxaluria

This can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver and spleen; and problems with the electrical system of the [counsyl.com]

Congenital Generalized Lipodystrophy

Additionally, congenital generalized lipodystrophy causes an abnormal buildup of fats in the liver (hepatic steatosis), which can result in an enlarged liver (hepatomegaly [ghr.nlm.nih.gov]

Consequently, affected individuals may develop abnormal enlargement of the muscles (muscular hypertrophy) or the liver (hepatomegaly). [rarediseases.org]

Infants usually develop an enlarged liver. Young kids have problems controlling their blood sugar and triglyceride levels. [webmd.com]

Progressive Familial Intrahepatic Cholestasis

Excess bile salts are stored in the liver cells and leak into the bloodstream, resulting in severe itching, jaundice, and an enlarged liver. [sema4genomics.com]

[…] of the liver and spleen that is not normal Fatigue (tired all of the time) Poor feeding, upset belly, and throwing up Problems that may arise include: Problems absorbing [cincinnatichildrens.org]

Liver disease related symptoms and consequences include: pruritus (severe itching) jaundice (yellowing of skin and whites of eyes) fatigue enlarged liver or spleen cirrhosis [liver.ca]

Hodgkin Lymphoma

Other symptoms may include an enlarged spleen or liver, fever, weight loss, sweating and chills, and fatigue. [nfcr.org]

Hepatosplenomegaly: the enlargement of both the liver and spleen caused by the same disease. [slideshare.net]

Symptoms Painless local or disseminated lymph node enlargement, swelling of liver and spleen, unexplained fever, and diffuse itch. [symptoma.com]

Essential Thrombocythemia

This progressive disorder results in bone marrow scarring, leading to severe anemia and enlargement of your liver and spleen. [mayoclinic.org]

If a patient shows up with enlarged spleen or liver which means that you have blood production taking place outside the bone marrow, treatment is a very good idea. [medlink.com]

Infectious Mononucleosis

Other symptoms of mono are fatigue, decreased appetite, myalgias (body aches), rash, headache, swollen tonsils, enlarged spleen, enlarged liver and even night sweats. [mydrnow.com]

Symptoms Symptoms of EBV infection can include fatigue fever inflamed throat swollen lymph nodes in the neck enlarged spleen swollen liver rash Many people become infected [cdc.gov]

The main concern is the risk of an enlarged spleen rupturing. [mydrnow.com]

Infantile Hepatic Hemangioendothelioma

Physical examination revealed enlarged liver. Unenhanced abdominal CT showed enlargement of the liver with diffuse hypodensity. [ncbi.nlm.nih.gov]

[…] of the liver with diffuse hypodensity. [journals.lww.com]

The ultrasound examination revealed multiple hypoechoic liver lesions coexisting with an enlarged liver. [em-consulte.com]

Schnitzler Syndrome

[…] spleen and liver. [1] Schnitzler syndrome is considered an autoinflammatory disorder and is generally treated with anakinra, which inhibits interleukin 1. [en.wikipedia.org]

[…] age of chronic hives (urticaria) and periodic fever, bone pain and joint pain (sometimes with joint inflammation ), weight loss, malaise, fatigue, swollen lymph glands and enlarged [en.wikipedia.org]

[…] spleen or liver, elevated erythrocyte sedimentation rate, high levels of white blood cells, and findings of problems in bone imaging. [1] [2] In the Strasbourg criteria, [en.wikipedia.org]

Macronodular Cirrhosis

In the early stages, liver enlargement may reflect fatty infiltration of liver cells (fatty cirrhosis) with necrosis and inflammation due to acute alcohol injury; progressive [medical-dictionary.thefreedictionary.com]

Essentially, micronodular cirrhosis is a type of cirrhosis whereby there are morphological changes that cause an enlarged liver. [healthery.com]

[…] with hepatic enlargement (the liver may shrink when complete loss of function is present). [medical-dictionary.thefreedictionary.com]

Systemic Juvenile Idiopathic Arthritis

It can cause swollen lymph nodes, and an enlarged spleen and liver. Children who have it may grow more slowly than normal. [webmd.com]

[…] glands, enlarged spleen and liver, tachycardia, the dreaded sore throat and swallowing problems, episodes of Pericarditis and then the funky bloodwork. [stillslife.wordpress.com]

Predominantly extra-articular manifestations like high fevers, rheumatic rash, enlargement of the liver and spleen, enlargement of the lymph nodes, and anemia. [en.wikipedia.org]

Myelofibrosis

After splenectomy, some patients can experience enlargement of the liver and a great increase in platelet count. [epainassist.com]

The result is extensive scarring in your bone marrow, leading to severe anemia, weakness, fatigue, and often, an enlarged spleen and liver.'' [cmleukemia.com]

This results in massive scarring in the bone marrow leading to severe anemia, fatigue, weakness and usually an enlarged liver and spleen. [epainassist.com]

Mauriac Syndrome

[…] hepatopathy (GH) The other main cause of liver enlargement and deranged liver tests related in diabetes mellitus is fatty liver. [qingningbian.blogspot.com]

[…] cells, thus causing the liver enlargement. [pediatrics.wisc.edu]

As a result, the liver becomes enlarged. [archive.jsonline.com]

Spleen Disease

Usually, your doctor will identify the enlargement of the liver during the physical examination that is by palpating your abdomen. [gleneaglesglobalhospitals.com]

Persons with an enlarged spleen often exhibit other signs and symptoms associated with the underlying cause of the enlargement, such as liver disease, an infection or a blood [livestrong.com]

Finding the cause Sometimes you may need more testing to find the cause of an enlarged spleen, including liver function tests and a bone marrow exam. [mayoclinic.org]

Glycogen Storage Disease Type 4

[…] puberty Bone thinning from osteoporosis Increased mouth ulcers and infection Type II - Pompe's Disease Enlarged liver and heart In severe cases, muscle weakness and heart [chp.edu]

The symptoms of disease in the liver group are similar, ranging from symptomatic hypoglycemia and ketoacidosis to largely asymptomatic enlargement of the liver (hepatomegaly [britannica.com]

Other types manifest enlarged spleen and liver as well progression to liver cirrhosis in adults and growth retardation in children. [mazornet.com]

Glycogen Storage Disease Type 1

Symptoms appear in early childhood and include dangerously low blood sugar (hypoglycemia), delayed development, recurrent infection, and enlargement of the liver, spleen, [geneticdiseasefoundation.org]

[…] of the liver, heart, or striated muscle, including the … Medical dictionary syndrome — The aggregate of symptoms and signs associated with any morbid process, and constituting [medicine.academic.ru]

[…] puberty Bone thinning from osteoporosis Increased mouth ulcers and infection Type II - Pompe's Disease Enlarged liver and heart In severe cases, muscle weakness and heart [chp.edu]

Glycogen Storage Disease

Symptoms and signs depend upon the exact type but can include enlargement of the liver (hepatomegaly), hypoglycemia, and muscle weakness or cramps eventually accompanied by [medicinenet.com]

[…] bowel disease GSD II (Pompe disease) All organs Enlarged liver and heart and muscle weakness GSD III (Cori disease, Forbes disease) Liver, muscle, and heart Enlarged liver [merckmanuals.com]

The conditions may affect the liver or the skeletal (striated) muscle, both primary glycogen storage sites. [medicinenet.com]

Niemann-Pick Disease

The disease primarily affects the: liver spleen brain bone marrow This leads to enlargement of the spleen and neurologic problems. [healthline.com]

A patient may also have skin discoloration and enlarged liver, spleen and lymph nodes. [cedars-sinai.edu]

liver or spleen. [healthline.com]

Niemann-Pick Disease Type B

The main features of Niemann-Pick disease type B (NPD-B) are enlargement of the liver and spleen, and mild pulmonary involvement. [ncbi.nlm.nih.gov]

Failure to break down sphingomyelin causes an accumulation and enlargement of the liver and spleen. [npuk.org]

The disease primarily affects the: liver spleen brain bone marrow This leads to enlargement of the spleen and neurologic problems. [healthline.com]

Glycogen Storage Disease Type 6

Growth rate may be slowed, and enlargement of the liver may occur because of an excess accumulation of glycogen. [rarediseases.org]

The symptoms of disease in the liver group are similar, ranging from symptomatic hypoglycemia and ketoacidosis to largely asymptomatic enlargement of the liver (hepatomegaly [britannica.com]

This accounts for the enlarged liver and swollen abdomen and produces symptoms of low blood sugar. [agsd.org.uk]