Possible Causes for enlargement of the liver Gaucher Disease The disorder is characterized by bruising, fatigue, anemia, low blood platelet count and enlargement of the liver and spleen, and is caused by a hereditary deficiency of the [en.wikipedia.org] People in this group usually bruise easily due to low blood platelets and experience fatigue due to anemia They also may have an enlarged liver and spleen. [ninds.nih.gov] [britannica.com] Enlargement of the Liver Type 1 Gaucher disease (GD1) is characterized by thrombocytopenia, anemia, an enlarged spleen, and liver as well as bone complications [symptoma.com] Chronic Lymphocytic Leukemia […] nodes; stage II, lymphocytosis with enlarged spleen or liver or both; stage III, lymphocytosis with anemia; and stage IV:lymphocytosis with thrombocytopenia. [ncbi.nlm.nih.gov] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia. [ncbi.nlm.nih.gov] Symptoms of CLL may include: Abnormal bruising (if platelets are low) Enlarged lymph nodes, liver, or spleen Excessive sweating, night sweats Fatigue Fever Infections that [nlm.nih.gov] Mucopolysaccharidosis […] of the liver and spleen and decreased range of motion and mobility. [efpia.eu] Symptoms include dwarfism, severe bone disease, including facial deformity, degenerative joint disease, enlarged liver and eye cloudiness. [vetgen.com] Coarsening of facial features and enlargement of the liver and spleen occurs over the first few months. If untreated, death occurs in the first decade. [medicalhomeportal.org] Cytomegalovirus Infection […] spleen and liver, jaundice, and a rash caused by bleeding underneath the skin. [babycenter.com] […] of the liver and spleen with jaundice, to stillbirth or neonatal/infant death. [ideas.health.vic.gov.au] The following potential problems can occur for infants who are infected from their mothers before birth (during pregnancy): Moderate enlargement of the liver and spleen, small [americanpregnancy.org] Niemann-Pick Disease Type C Accumulation of cholesterol inside lysosomes leads to fatal symptoms, such as progressive nerve degeneration, and enlargement of the liver and spleen. [sciencedaily.com] After taking two-month-old Kamryn to the doctor for a bloated stomach, the Brumbeloe’s learned that she had an enlarged spleen and liver and were referred to the Children’ [childrensinn.org] Visceral symptoms include: Enlargement of the liver (hepatomegaly) Jaundice in newborns, which is very common and therefore often not immediately associated with NP‑C Enlargement [www1.actelion.com] Hodgkin Lymphoma Other symptoms may include an enlarged spleen or liver, fever, weight loss, sweating and chills, and fatigue. [nfcr.org] Symptoms Painless local or disseminated lymph node enlargement, swelling of liver and spleen, unexplained fever, and diffuse itch. [symptoma.com] Hepatosplenomegaly: the enlargement of both the liver and spleen caused by the same disease. [slideshare.net] Progressive Familial Intrahepatic Cholestasis […] of the liver and spleen that is not normal Fatigue (tired all of the time) Poor feeding, upset belly, and throwing up Problems that may arise include: Problems absorbing [cincinnatichildrens.org] Excess bile salts are stored in the liver cells and leak into the bloodstream, resulting in severe itching, jaundice, and an enlarged liver. [sema4genomics.com] Liver disease related symptoms and consequences include: pruritus (severe itching) jaundice (yellowing of skin and whites of eyes) fatigue enlarged liver or spleen cirrhosis [liver.ca] Lipodystrophy Children can also develop periorbital edema (swelling around the eye sockets), and edema (clubbing) of finger and/or toes, and gradual enlargement of the liver, along with [autoinflammatory.org] There may be abnormal breakdown of fats with loss of weight, excessive levels of fats in the blood, raised blood sugar levels, enlargement of the liver and abnormal thyroid [medical-dictionary.thefreedictionary.com] This condition results in enlargement of the liver and kidneys. [epainassist.com] Mucopolysaccharidosis Type 1 Enlargement of the liver and spleen. [rarediseases.org] They can develop an enlarged liver (hepatomegaly), clouding of the cornea, and heart valve abnormalities during their teen-aged years. [rarediseases.org] This is detected by the doctor when the child is examined but the enlargement of the liver and spleen does not lead to symptoms themselves. [rarediseases.org] Mucopolysaccharidosis Type 3 Patients with MPS 7 may have abnormal coarsened facial features, enlargement of the liver and spleen, airway obstruction, lung disease, cardiovascular complications, joint [ultragenyx.com] Although the clinical features of the disease are mainly neurological, patients may also develop diarrhea, carious teeth, and an enlarged liver and spleen. [checkorphan.org] Additional findings include short stature, heart abnormalities, breathing irregularities, liver and spleen enlargement (hepatosplenomegaly), and/or neurological abnormalities [rarediseases.org] Essential Thrombocythemia This progressive disorder results in bone marrow scarring, leading to severe anemia and enlargement of your liver and spleen. [mayoclinic.org] If a patient shows up with enlarged spleen or liver which means that you have blood production taking place outside the bone marrow, treatment is a very good idea. [medlink.com] Congenital Generalized Lipodystrophy Additionally, congenital generalized lipodystrophy causes an abnormal buildup of fats in the liver (hepatic steatosis), which can result in an enlarged liver (hepatomegaly [ghr.nlm.nih.gov] Consequently, affected individuals may develop abnormal enlargement of the muscles (muscular hypertrophy) or the liver (hepatomegaly). [rarediseases.org] Infants usually develop an enlarged liver. Young kids have problems controlling their blood sugar and triglyceride levels. [webmd.com] Primary Hyperoxaluria This can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver and spleen; and problems with the electrical system of the [counsyl.com] Insoluble calcium deposits in other body tissues can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver and spleen; and [myriadwomenshealth.com] […] spleen or liver skin problems, including livedo reticularis, rash, necrosis, and gangrene of the hands and feet Primary hyperoxaluria is a rare genetic disorder that can [healthline.com] Primary Hyperoxaluria Type 1 [counsyl.com] Insoluble calcium deposits in other body tissues can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver [symptoma.com] Insoluble calcium deposits in other body tissues can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver and spleen; and [myriadwomenshealth.com] […] spleen or liver skin problems, including livedo reticularis, rash, necrosis, and gangrene of the hands and feet Primary hyperoxaluria is a rare genetic disorder that can [healthline.com] Niemann-Pick Disease The disease primarily affects the: liver spleen brain bone marrow This leads to enlargement of the spleen and neurologic problems. [healthline.com] A patient may also have skin discoloration and enlarged liver, spleen and lymph nodes. [cedars-sinai.edu] liver or spleen. [healthline.com] Gaucher Disease Type 2 The disorder is characterized by bruising, fatigue, anemia, low blood platelet count and enlargement of the liver and spleen, and is caused by a hereditary deficiency of the [en.wikipedia.org] Symptoms usually develop by 3 months of age and include brain damage, seizures, abnormal eye movements, poor ability to suck and swallow, and enlargement of the liver and [rarediseases.info.nih.gov] As indicated, enlargement of the liver is characteristic in all Gaucher disease patients. In severe cases the liver can fill the entire abdomen. [themedicalbiochemistrypage.org] Infectious Mononucleosis Symptoms Symptoms of EBV infection can include fatigue fever inflamed throat swollen lymph nodes in the neck enlarged spleen swollen liver rash Many people become infected [cdc.gov] Other symptoms of mono are fatigue, decreased appetite, myalgias (body aches), rash, headache, swollen tonsils, enlarged spleen, enlarged liver and even night sweats. [mydrnow.com] The main concern is the risk of an enlarged spleen rupturing. [mydrnow.com] Infantile Hepatic Hemangioendothelioma Physical examination revealed enlarged liver. Unenhanced abdominal CT showed enlargement of the liver with diffuse hypodensity. [ncbi.nlm.nih.gov] […] of the liver with diffuse hypodensity. [journals.lww.com] An abdominal CT scan showed an enlarged, irregularly shaped liver with multiple intrahepatic masses (Fig. 1C). [journals.lww.com] Primary Hyperoxaluria Type 3 This can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver and spleen; and problems with the electrical system of the [nxgenmdx.com] [counsyl.com] Insoluble calcium deposits in other body tissues can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver [symptoma.com] Insoluble calcium deposits in other body tissues can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver and spleen; and [myriadwomenshealth.com] Glycogen Storage Disease Type 1 Symptoms appear in early childhood and include dangerously low blood sugar (hypoglycemia), delayed development, recurrent infection, and enlargement of the liver, spleen, [geneticdiseasefoundation.org] […] of the liver, heart, or striated muscle, including the … Medical dictionary syndrome — The aggregate of symptoms and signs associated with any morbid process, and constituting [medicine.academic.ru] The symptoms of disease in the liver group are similar, ranging from symptomatic hypoglycemia and ketoacidosis to largely asymptomatic enlargement of the liver (hepatomegaly [britannica.com] Glycogen Storage Disease Type 4 The symptoms of disease in the liver group are similar, ranging from symptomatic hypoglycemia and ketoacidosis to largely asymptomatic enlargement of the liver (hepatomegaly [britannica.com] Some potential complications associated with Andersen's Disease include: Scarring of the liver; liver cirrhosis Liver failure Development of an enlarged spleen (splenomegaly [dovemed.com] Other types manifest enlarged spleen and liver as well progression to liver cirrhosis in adults and growth retardation in children. [mazornet.com] Glycogen Storage Disease Symptoms and signs depend upon the exact type but can include enlargement of the liver (hepatomegaly), hypoglycemia, and muscle weakness or cramps eventually accompanied by [medicinenet.com] Fats get stored in the liver along with the glycogen, which leads to the enlargement of the liver. [agsdus.org] The conditions may affect the liver or the skeletal (striated) muscle, both primary glycogen storage sites. [medicinenet.com] Primary Hyperoxaluria Type 2 [counsyl.com] Insoluble calcium deposits in other body tissues can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver [symptoma.com] Insoluble calcium deposits in other body tissues can lead to bone pain; vision loss; tingling, numbness, or pain in the extremities; enlargement of the liver and spleen; and [myriadwomenshealth.com] […] spleen or liver skin problems, including livedo reticularis, rash, necrosis, and gangrene of the hands and feet Primary hyperoxaluria is a rare genetic disorder that can [healthline.com] Myelofibrosis My husband was diagnosed with MF in 2004, no symptoms, JAK neg, just enlarged spleen and liver. [csn.cancer.org] The result is extensive scarring in your bone marrow, leading to severe anemia, weakness, fatigue, and often, an enlarged spleen and liver.'' [cmleukemia.com] Glycogen Storage Disease Type 6 Growth rate may be slowed, and enlargement of the liver may occur because of an excess accumulation of glycogen. [rarediseases.org] This accounts for the enlarged liver and swollen abdomen and produces symptoms of low blood sugar. [agsd.org.uk] The symptoms of disease in the liver group are similar, ranging from symptomatic hypoglycemia and ketoacidosis to largely asymptomatic enlargement of the liver (hepatomegaly [britannica.com] Niemann-Pick Disease Type B The main features of Niemann-Pick disease type B (NPD-B) are enlargement of the liver and spleen, and mild pulmonary involvement. [ncbi.nlm.nih.gov] Niemann-Pick Type A / B [SMPD1]: Severe neurodegenerative condition, loss of brain function and enlargement of the liver and spleen, average life expectancy 2–3 years of age [jewishgeneticdiseases.org] Failure to break down sphingomyelin causes an accumulation and enlargement of the liver and spleen. [npuk.org] Hemochromatosis This may eventually lead to serious problems such as: Arthritis Liver disease, including an enlarged liver, cirrhosis, liver cancer, or liver failure Damage to the pancreas [winchesterhospital.org] Hepatomegaly is enlargement of the liver beyond its normal size. [mountsinai.org] Hemochromatosis can lead to two major liver issues: hepatomegaly and cirrhosis. Hepatomegaly is the enlargement of the liver and cirrhosis is the scarring of the liver. [hepb.org] Schnitzler Syndrome […] spleen and liver. [1] Schnitzler syndrome is considered an autoinflammatory disorder and is generally treated with anakinra, which inhibits interleukin 1. [en.wikipedia.org] […] age of chronic hives (urticaria) and periodic fever, bone pain and joint pain (sometimes with joint inflammation ), weight loss, malaise, fatigue, swollen lymph glands and enlarged [en.wikipedia.org] […] spleen or liver, elevated erythrocyte sedimentation rate, high levels of white blood cells, and findings of problems in bone imaging. [1] [2] In the Strasbourg criteria, [en.wikipedia.org] Hydropericardium Enlarged, pale friable liver and kidney. Congestion of the carcase. Lungs oedematous. Diagnosis Lesions, histopathology, virology. Treatment None. [thepoultrysite.com] […] mottled and friable livers, with intranuclear inclusion bodies in the hepatocytes. [ncbi.nlm.nih.gov] […] of poultry, particularly of 3- to 6-week-old broiler chicks, characterized by its sudden onset, with high mortality ranging from 20% to 70%, typical hydropericardium and enlarged [ncbi.nlm.nih.gov] Juvenile-Onset Still Disease Predominantly extra-articular manifestations like high fevers, rheumatic rash, enlargement of the liver and spleen, enlargement of the lymph nodes, and anemia. [en.wikipedia.org] Other Still's disease symptoms.are: Poor appetite, nausea, and weight loss are common There is also commonly swelling of the lymph glands, enlargement of the spleen and liver [medicinenet.com] It can cause swollen lymph nodes, and an enlarged spleen and liver. Children who have it may grow more slowly than normal. [webmd.com]
