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1,833 Possible Causes for Enlargement of the Spleen

  • Portal Cirrhosis

    Other complications Portal hypertension may cause the spleen to become enlarged.[] Other later symptoms, some due to complications, include: Reddened palms Loss of body hair Enlarged liver Enlarged spleen Appearance of thin, purplish-red, spidery looking[] Splenomegaly Increased pressure in the portal vein is conducted to the splenic vein resulting in congestive enlargement of the spleen.[]

  • Macronodular Cirrhosis

    Splenomegaly Increased pressure in the portal vein is conducted to the splenic vein resulting in congestive enlargement of the spleen.[] The physical exam can show signs such as: pale skin yellow eyes (jaundice) reddened palms hand tremors an enlarged liver or spleen small testicles excess breast tissue (in[] […] of the spleen, enlargement of the veins in the oesophagus (gullet) (which may rupture to cause severe bleeding), and accumulation of fluid in the peritoneal cavity (ascites[]

  • Cryptogenic Cirrhosis

    Enlargement of the spleen (splenomegaly). Portal hypertension can also cause changes to and swelling of the spleen, and trapping of white blood cells and platelets.[] […] blood vessels just beneath the skin's surface Enlarged breasts in men Enlarged spleen Red palms Yellowing of the skin and eyes (jaundice) When to see a doctor Make an appointment[] Fatigue Pain in the upper right abdomen Possible signs and symptoms of nonalcoholic steatohepatitis and cirrhosis (advanced scarring) include: Abdominal swelling (ascites) Enlarged[]

  • Gaucher Disease

    People in this group usually bruise easily due to low blood platelets and experience fatigue due to anemia They also may have an enlarged liver and spleen.[] Mutations in GBA lead to the accumulation of glycosylceramide in the lysosome causing an enlargement of the spleen and the liver and skeletal deformations.[] […] of the spleen and liver, bone lesions, and sometimes neurological impairment Note: Gaucher disease is inherited as an autosomal recessive trait requiring that both parents[]

  • Chronic Lymphocytic Leukemia

    The disease often involves enlargement of lymph nodes in various parts of the body as well as enlargement of the spleen.[] CLL leads to unspecific symptoms such as general malaise and weakness, fever, night sweats, weight loss and enlarged lymph nodes, spleen or liver.[] (enlarged liver and spleen), anemia (low red blood cell count), or thrombocytopenia (low platelet count).[]

  • Mucopolysaccharidosis

    […] tongue), corneal clouding, hearing loss, heart problems, an enlarged liver and spleen, hernias, chronic nasal congestion and ear infections.[] […] liver and spleen (hepatosplenomegaly), and a large tongue (macroglossia).[] ERT may improve growth, joint movement, sleep apnea, respiratory function, pain levels, vision, and liver/spleen enlargement.[]

  • Splenic Subcapsular Hematoma

    Enlargement of the spleen (for example, due to Epstein-Barr virus causing infectious mononucleosis ) makes the spleen more susceptible to injury.[] Intraparenchymal hematomas appear broader; irregularly shaped; and hypodense, isodense, or even hyperdense and cause enlargement of the spleen and mass effect.[] . 7 Pathologic Conditions of the Spleen Splenomegaly Splenomegaly is the acute or chronic enlargement of the spleen, defined as a weight of greater than 250 g and a sonographic[]

  • Cytomegalovirus Infection

    Older kids and teens who are infected may have mono-like symptoms, including tiredness, muscle aches, headache , fever , and an enlarged liver and spleen.[] […] liver and spleen), mental or motor retardation, and sometimes death. 2.[] Symptoms may include: Fever Headache Fatigue Muscle aches Enlarged glands Sore throat Enlarged spleen.[]

  • Mucopolysaccharidosis 2

    Individuals with this disorder may experience the following signs: abnormal retina, heart murmur and leaky heart valves, enlarged liver (hepatomegaly) enlarged spleen (splenomegaly[] There are some obvious physical signs of Hunter syndrome, such as coarse facial features and an enlarged liver and spleen, as well as some less noticeable symptoms. 2 Symptoms[] […] liver Enlarged spleen Hernia in the groin Joint contractures (from joint stiffness) Tests may include: Enzyme study Genetic testing for a change in the iduronate sulfatase[]

  • Primary Biliary Cirrhosis

    Complications from Primary Biliary Cirrhosis can include hypersplenism (enlargement of the spleen), hepatic encephalopathy (confusion or coma resulting from liver failure)[] Enlarged spleen (splenomegaly).[]

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