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925 Possible Causes for Enlargement of the Spleen, Fatigue, Peripheral Neuropathy, Relapsing Polychondritis

  • Primary Biliary Cirrhosis

    Complications from Primary Biliary Cirrhosis can include hypersplenism (enlargement of the spleen), hepatic encephalopathy (confusion or coma resulting from liver failure)[disability-benefits-help.org] This Review article discusses the natural history and the measurement of fatigue in patients with PBC.[ncbi.nlm.nih.gov] Peripheral neuropathy and other autoimmune disorders associated with PBC may also develop.[merckmanuals.com] Enlarged spleen (splenomegaly).[mayoclinic.org]

  • Rheumatoid Arthritis

    Felty's syndrome (enlarged spleen and low white cell count); can present with an infection or leg ulcer. Amyloidosis (rare). Anaemia .[patient.info] ; NNTB 10, 95% CI 6 to 33) demonstrating a small beneficial effect upon fatigue.[ncbi.nlm.nih.gov] The most common neurologic manifestation of rheumatoid arthritis is a mild, primarily sensory peripheral neuropathy, usually more marked in the lower extremities.[hopkinsarthritis.org] TY Chuah and NL Lui , Relapsing polychondritis in Singapore: a case series and review of literature , Singapore Medical Journal , 58 , 4 , (201) , (2017) .[doi.org]

  • Multiple Myeloma

    Other symptoms can include stroke , gastrointestinal disorders, enlarged liver , diminished spleen function , diminished function of the adrenal and other endocrine glands[en.wikipedia.org] She developed G2 AEs, including nausea and fatigue. The cardiac amyloidosis worsened, and she died of heart and renal failure.[ncbi.nlm.nih.gov] The mechanism of the development of the peripheral neuropathy is poorly understood.[ncbi.nlm.nih.gov] In the bone marrow, myeloma cells crowd out healthy white blood cells and red blood cells, leading to fatigue and an inability to fight infections.[mayoclinic.org]

  • Gaucher Disease

    [en.oxforddictionaries.com] Enlargement of the Spleen Mutations in GBA lead to the accumulation of glycosylceramide in the lysosome causing an enlargement of the spleen and[symptoma.com] Hematologic changes, bone pain, hepatomegaly, splenomegaly, and fatigue were the most recurrent signs and symptoms.[ncbi.nlm.nih.gov] Comorbidities for peripheral neuropathy were excluded.[ncbi.nlm.nih.gov] Fatigue prolonged bleeding fever, chills, sweating seizure developmental delay Orthopaedics Bone fractures/osteomyelitis joint pain/contractures bone necrosis/ osteonecrosis[brainscape.com]

    Missing: Relapsing Polychondritis
  • Chronic Lymphocytic Leukemia

    The disease often involves enlargement of lymph nodes in various parts of the body as well as enlargement of the spleen.[texasoncology.com] Symptoms of CLL may include: Abnormal bruising (if platelets are low) Enlarged lymph nodes , liver, or spleen Excessive sweating , night sweats Fatigue Fever Infections that[nlm.nih.gov] I had bad peripheral neuropathy of the legs after using a small dose of vincristine in 2007; Dr.[clldiary.blogspot.com] FINDINGS: Common adverse events were neutropenia, diarrhea, nausea, anemia, upper respiratory tract infection, thrombocytopenia, and fatigue.[ncbi.nlm.nih.gov]

    Missing: Relapsing Polychondritis
  • Myeloproliferative Disease

    In some cases there is also a slight enlargement of the spleen.[knowcancer.com] We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: January 30, 2019[patientslikeme.com] neuropathy remains unaltered.[doi.org] In around a third of cases the spleen is very enlarged.[leukaemia.org.au]

  • Infectious Mononucleosis

    Enlargement of the spleen Mononucleosis may cause enlargement of the spleen.[mayoclinic.com] Fatigue can sometimes persist for longer. In most people, fatigue will end after three months.[web.archive.org] Neurologic complications are rare but may include encephalitis, seizures, Guillain-Barré syndrome, peripheral neuropathy, viral meningitis, myelitis, cranial nerve palsies[merck.com] A diagnosis of acute symmetrical sensorimotor peripheral neuropathy (Guillain-Barré syndrome) was made. The results of CSF cultures were negative.[dx.doi.org]

    Missing: Relapsing Polychondritis
  • Granulomatosis with Polyangiitis

    spleen.[medical-dictionary.thefreedictionary.com] We present an interesting case of a 14-year-old female with eight-weeks of bilateral otalgia, unilateral facial nerve palsy, decreased appetite, and fatigue refractory to[ncbi.nlm.nih.gov] neuropathy 名前の由来 Friedrich Wegener 典拠管理 Q1161568 Reasonator Scholia 統計学 下位カテゴリ このカテゴリに属する 3 個のサブカテゴリのうち、 3 個を表示しています。[commons.wikimedia.org] The perinuclear pattern, or p-ANCA, is associated with PAN, microscopic polyarteritis nodosa, relapsing polychondritis, and renal vasculitis.[aao.org]

  • Vitamin B12 Deficiency

    Upon admission, his weight, length and head circumference were below the third percentile, he had an enlarged liver and spleen, and showed a significant delay in developmental[ncbi.nlm.nih.gov] The clinical symptoms are weakness, fatigue, shortness of breath and neurologic abnormalities.[ncbi.nlm.nih.gov] Participation included measuring vitamin B12 levels and assessing peripheral neuropathy using Neuropathy Total Symptom Score-6 (NTSS-6) questionnaire.[ncbi.nlm.nih.gov] […] liver and spleen Persistence of hypotonia and mildly enlarged liver and spleen Persistence of mild hypotonia and mildly enlarged liver and spleen Persistence of mild hypotonia[doi.org]

    Missing: Relapsing Polychondritis
  • Acute Erythroblastic Leukemia

    Additionally, patients may also show considerable enlargement of the spleen and liver, which can be noticed by the telltale swelling of the abdomen and can be easily detected[medigest.uk] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, and granulocytopenia that leads to persistent bacterial infections.[medical-dictionary.thefreedictionary.com] Associations There is an association with autoimmune abnormalities, eg arthritis, peripheral neuropathy, vasculitis, iritis, myositis. [ 5 ] No causal relationship has been[patient.info] […] or liver are enlarged; and whether the blood disorders anemia (too few red blood cells) or thrombocytopenia (too few platelets) have developed.[cancercenter.com]

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