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764 Possible Causes for Enlargement of the Spleen, Foul Smelling Stool, Irritability, Liver Biopsy Abnormal, Pruritus

  • Progressive Familial Intrahepatic Cholestasis

    […] liver and spleen (hepatosplenomegaly).[ghr.nlm.nih.gov] […] progressive familial intrahepatic cholestasis (PFIC) Jaundice Scleral icterus Cutaneous jaundice Dark urine Physical See the list below: Pruritus Scratching Cutaneous mutilation Irritability[emedicine.medscape.com] Giant cell transformation was present in 56% of initial biopsies. Bile duct loss was a prominent and early finding and many biopsies had abnormal bile duct epithelium.[ncbi.nlm.nih.gov] Also, these patients produce copious amounts of foul-smelling stool, which may persist following liver transplant.[symptoma.com] Abstract Biliary diversion offers a potential option for intractable pruritus in children with chronic cholestatic disorders.[ncbi.nlm.nih.gov]

  • Primary Biliary Cirrhosis

    Complications from Primary Biliary Cirrhosis can include hypersplenism (enlargement of the spleen), hepatic encephalopathy (confusion or coma resulting from liver failure)[disability-benefits-help.org] Primary Sclerosing Cholangitis Wilson’s Disease Primary biliary cirrhosis (or PBC) is a condition in which the bile ducts (ducts that remove bile from the liver) become irritated[nyp.org] Biopsy of the liver tissue is also required to confirm the presence of PBC and to determine the extent of the disease.[symptoma.com] Intense pruritus can be itself an indication to liver transplantation, in extreme cases leading to suicide.[ncbi.nlm.nih.gov] Enlarged spleen (splenomegaly).[mayoclinic.org]

    Missing: Foul Smelling Stool
  • Secondary Biliary Cirrhosis

    It is marked by jaundice, abdominal pain, steatorrhea, and enlargement of the liver and spleen. congestive cirrhosis cirrhosis resulting from increased hepatic venous pressure[medical-dictionary.thefreedictionary.com] A liver biopsy should be performed confirm the diagnosis.[healthcentral.com] […] skin Fatigue Jaundice symptoms like yellowing of the eyes and skin Other manifestations may include: Darkening of exposed areas of the skin Fever Bone pain Pale-colored, foul-smelling[digestion.ygoy.com] SECONDARY BILIARY CI RR H OS I S Symptoms Clinical features · Jaundice · Pruritus · Biliary colics.[medicscientist.com] Enlarged spleen (splenomegaly).[mayoclinic.org]

  • Cystic Fibrosis

    This is because by the time liver disease is evident in a person with an enlarged liver or spleen, there is often already raised pressure in the large vein running through[doi.org] Seven patients were not able to complete the nebulization of colistin sulphate because of throat irritation and severe cough.[ncbi.nlm.nih.gov] […] become clearer in recent years that celiac disease is a clinical picture "characterized by arrest of growth, a distended abdomen, and attacks of diarrhoea with large, pale, foul-smelling[doi.org] 1 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0] 14.2 Pruritus 1 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0] 14.3 Urticaria 1 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0,[doi.org] Fecal transplant is used to treat gut infections and is now being studied as a treatment for obesity, urinary tract infections, irritable bowel syndrome and more.[nytimes.com]

  • Primary Sclerosing Cholangitis

    These include: an enlarged liver or spleen, anaemia , cirrhosis , female sex and older age. Increasing bilirubin also correlates with disease progression.[myvmc.com] This was observed in patients with PSC with and without irritable bowel disease and was distinct from IBD.[healio.com] Liver function tests then reveal more abnormalities.[chp.edu] Abstract Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of bile ducts..Patients with PSC usually presents with fatigue, jaundice and pruritus.[ncbi.nlm.nih.gov] Signs and symptoms that may appear as the disease progresses include: Pain in the upper right part of the abdomen Fever Chills Night sweats Enlarged liver Enlarged spleen[mayoclinic.org]

    Missing: Foul Smelling Stool
  • Systemic Mastocytosis

    On closer perusal of the abdominal radiograph an enlarged liver and spleen can be seen, and thus it was thought that this patient suffered from one of the anemias such as[healio.com] These spots are called urticaria pigmentosa and can transform into hives and itch if stroked or irritated, or if the skin is exposed to sudden changes in temperature such[aaaai.org] Concurrently, abnormally elevated liver enzymes (especially alkaline phosphatase) were noted and further workup with magnetic resonance cholangio-pancreatography and liver[acgcasereports.gi.org] Patients often feel faint, have skin problems, joint and bone pain, low blood counts and enlarged liver, spleen or lymph nodes.[clinicaltrials.gov] Irritable Bowel Syndrome. Medscape, Last Update October 10, 2016. Available at: . Accessed December 20, 2016. Rowe W, Lichtenstein GR. Irritable Bowel Disease.[rarediseases.org]

    Missing: Foul Smelling Stool
  • Erythropoietic Protoporphyria

    Build up of protoporphyrin can cause extreme sensitivity to sunlight, liver damage, abdominal pain, gallstones, and enlargement of the spleen.[checkorphan.org] […] highest doses of sunlight and the areas that are more shaded typically are not affected.[13] Non-skin symptoms have also been reported and involved difficulty with sleep, irritability[jcadonline.com] EPP usually presents in early childhood or infancy, with painful burning and pruritus within minutes of light exposure.[ncbi.nlm.nih.gov] Build up of protoporphyrin can cause extreme sensitivity to sunlight, liver damage, abdominal pain, gallstones, and enlargement of the spleen. [1] Inheritance is autosomal[rarediseases.info.nih.gov] There is irritation and blistering followed by increased skin fragility, hair growth, scarring and pigment deposition.[albertaporphyriasociety.weebly.com]

    Missing: Foul Smelling Stool
  • Autoimmune Hepatitis

    A pediatric specialist may find an enlarged liver or spleen during an examination of your child’s body. Blood tests.[rileychildrens.org] Across our AdventHealth network of care, we specialize in helping people like you learn to manage and overcome gastrointestinal disorders ranging from irritable bowel syndrome[floridahospital.com] A 61-year-old male was referred to our hospital because of abnormal liver enzyme levels after initial diagnosis of CAEBV had been made by laboratory tests and liver biopsy[ncbi.nlm.nih.gov] Fatigue Abdominal pain Joint pain Itching (pruritus) Jaundice An enlarged liver Abnormal blood vessels on the skin (spider angiomas) Nausea and vomiting Loss of appetite Skin[columbiasurgery.org] Enlargement of the spleen could mean that your child’s symptoms are caused by an infection.[nyulangone.org]

    Missing: Foul Smelling Stool
  • Indian Childhood Cirrhosis

    "The child had severe difficulty in breathing and had jaundice with enlargement of liver and spleen besides signs of liver and respiratory failure.[dailymail.co.uk] Disease onset is often gradual, with nonspecific signs such as malaise, irritability, sleeplessness, lack of appetite, constipation or diarrhea, fever and abdominal distension[symptoma.com] In four children, significant hepatosplenomegaly was associated with an abnormal duplex Doppler hepatic vein flow pattern and micronodular cirrhosis on biopsy.[ncbi.nlm.nih.gov] The initial presenting complaint was abdominal distention and pruritus. All three had a rapid and fatal course.[ingentaconnect.com] Other later symptoms, some due to complications, include: Reddened palms Loss of body hair Enlarged liver Enlarged spleen Appearance of thin, purplish-red, spidery looking[chp.edu]

    Missing: Foul Smelling Stool
  • Malignant Neoplasm of Pancreas

    […] in enlargement of the spleen (splenomegaly).[merckmanuals.com] These symptoms are commonly mistaken for other conditions such as irritable bowel syndrome, colitis, asthma, or menopause.[netrf.org] Observe and report any evidence of diarrhea or frothy, floating, foul-smelling stools (an indication of steatorrhea) because an adjustment in the enzyme replacement therapy[medical-dictionary.thefreedictionary.com] Symptoms may include: Feeling tired or weak Shaking or sweating Headache Hunger Nervousness, anxiety, or feeling irritable Unclear thinking or feeling uneasy Double or blurry[medlineplus.gov] Adenocarcinoma of the body or tail of the pancreas may obstruct the vein draining the spleen (the organ that produces, monitors, stores, and destroys blood cells), resulting[merckmanuals.com]

    Missing: Liver Biopsy Abnormal

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