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274 Possible Causes for Enlargement of the Spleen, Hashimoto's Thyroiditis, Splenomegaly

  • Chronic Lymphocytic Leukemia

    The disease often involves enlargement of lymph nodes in various parts of the body as well as enlargement of the spleen.[] In the physical examination, generalized lymphadenopathy and hepato- and/or splenomegaly may be noted.[] After 3 years, he presented a CLL progression with worsening lymphocytosis, anemia, thrombocytopenia, increased splenomegaly, and lymphadenopathies.[]

  • Sjogren's Syndrome

    There is also a common disease that is associated with Sjogren's syndrome on occasion; an autoimmune disease known as, 'Hashimoto's Thyroiditis,' that can lead to abnormal[] There may also be enlargement of the spleen, diminution in white blood cell numbers, Raynaud’s phenomenon, vasculitis (inflammation of vessels) with chronic leg ulcers, a[] On admission, she presented with anemia, elevated C-reactive protein levels, anasarca, and hepato-splenomegaly.[]

  • Primary Biliary Cirrhosis

    thyroiditis.[] Complications from Primary Biliary Cirrhosis can include hypersplenism (enlargement of the spleen), hepatic encephalopathy (confusion or coma resulting from liver failure)[] […] of the caudate lobe hepatic surface irregularity due to regenerative nodules regional lymphadenopathy: tends to dominate in the gastrohepatic ligament and porta hepatis 4 splenomegaly[]

  • Hemochromatosis

    Prevalences of Hashimoto's thyroiditis, rheumatoid arthritis, and ankylosing spondylitis were 8.1% (95% CI: [5.1, 12.5]), 1.7% [0.6, 4.6], and 0.0085 [0.0015, 0.0337], respectively[] The clinical manifestations include skin pigmentation, diabetes mellitus , enlargement of the spleen and liver , cirrhosis , heart failure , arthritis , and general weakness[] Regression on SF revealed significant associations: TS; male sex; age; GGT; transfusion units (positive); and splenomegaly (negative) (p 0.0001, 0.0016, 0.0281, 0.0025, 0.0001[]

  • Mixed Connective Tissue Disease

    We report the case of a 63-year-old woman who suffered from mixed connective tissue disease (MCTD) complicated with thymic carcinoma and Hashimoto's thyroiditis.[] Patients may also develop problems swallowing, gastrointestinal difficulties, kidney disease, or enlargement of the spleen or liver.[] She was found to have splenomegaly, generalized lymphadenopathy, pancytopenia, and acute hepatic failure.[]

  • Autoimmune Hepatitis

    Hashimoto thyroiditis (HT) is the most common pediatric autoimmune endocrine disorder.[] A pediatric specialist may find an enlarged liver or spleen during an examination of your child’s body. Blood tests.[] Physical exam was remarkable for digital clubbing, splenomegaly and orthodeoxia.[]

  • Amyloidosis

    A firm, symmetrical, non-tender goitre resembling Hashimoto's thyroiditis may result from amyloidosis of the thyroid gland.[] ., discoloration and nodule formation), heart failure, kidney failure , and enlargement of the spleen and liver.[] We reported two cases with ApoA-1 amyloidosis, a 64-year-old man suffering from nephrotic syndrome and a 40-year-old man with nephrotic syndrome and splenomegaly.[]

  • Lysinuric Protein Intolerance

    […] disease , see Hashimoto thyroiditis Hashimoto struma , see Hashimoto thyroiditis Hashimoto syndrome , see Hashimoto thyroiditis Hashimoto thyroiditis Hashimoto's disease[] The patients show failure to thrive , poor appetite , growth retardation, enlarged liver and spleen , prominent osteoporosis and osteopenia , [2] delayed bone age and spontaneous[] A 5-year-old girl exhibiting aversion to protein-rich food and splenomegaly presented with a history of recurrent ischemic strokes.[]

  • Hemolytic Anemia

    Autoimmune disease : Most common in older children and includes systemic lupus erythematous, sjogrens, juvenile rheumatoid arthritis, ulcerative colitis and hashimotos thyroiditis[] […] liver and spleen Exercise intolerance Fever Decrease in urine output How Is Hemolytic Anemia Treated?[] […] suffer from a mild hemolytic anemia (Hb levels ranging from 10 to 12.7g/mL) associated with macrocytosis, reticulocytosis, hyperbilirubinemia, hyperferritinemia and slight splenomegaly[]

  • Primary Sclerosing Cholangitis

    thyroiditis This change is due to melanin deposition, not jaundice The cause is unknown, but similar findings occur in other types of chronic liver disease, such as hemochromatosis[] These include: an enlarged liver or spleen, anaemia , cirrhosis , female sex and older age. Increasing bilirubin also correlates with disease progression.[] Signs and symptoms that may appear as the disease progresses include: Pain in the upper right part of the abdomen Fever Chills Night sweats Enlarged liver Enlarged spleen[]

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