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35 Possible Causes for Enlargement of the Spleen, Intermittent Jaundice, Uric Acid Increased

  • Hereditary Spherocytosis

    This leads to ANAEMIA, and the scavenging of the destroyed red cells causes enlargement of the spleen (splenomegaly).[medical-dictionary.thefreedictionary.com] Abstract Hereditary spherocytosis is an autosomal dominant congenital hemolytic anemia due to defect in RBC membrane protein that commonly presents with intermittent jaundice[ncbi.nlm.nih.gov] Dubin-Johnson syndrome is a chronic, benign, intermittent jaundice, mostly of conjugated hyperbilirubinemia.[ncbi.nlm.nih.gov]

  • Sickle Cell Disease

    It causes a sudden, painful enlargement of the spleen.[healthline.com] Jaundice Fatigue Swollen hands and feet The severity of these symptoms can vary significantly for each individual with the disease, according to the specific characteristics[news-medical.net] This complication is characterized by the onset of life-threatening anemia with rapid enlargement of the spleen and high reticulocyte count.[emedicine.medscape.com]

  • Hepatorenal Syndrome

    spleen (splenomegaly) and an enlarged, extremely tender liver (hepatomegaly).[rarediseases.org] Wui-Chiang Lee, Han-Chieh Lin, Ming-Chih Hou, Hsiao-Yi Lin, Fa-Yauh Lee, Sun-Sang Wang, Full-Young Chang and Shou-Dong Lee , Serum Uric Acid Levels in Patients With Cirrhosis[doi.org] Severe circulatory dysfunction (mean arterial pressure usually is 70 mm Hg) and very low systemic vascular resistance. • Severe liver disease, with jaundice, coagulopathy,[scielo.mec.pt]

  • Congenital Liver Cirrhosis

    Splenomegaly or enlargement of the spleen.[medicinenet.com] acid level elevated Maternal mortality, 1%; prematurity and fetal death, 5%-30% Beta blocker, methyldopa, magnesium sulfate; early delivery HELLP syndrome Beyond 22 wk and[clevelandclinicmeded.com] He had intermittent high grade fever with dry cough and respiratory distress for 4 days duration.[indianpediatrics.net]

  • Primary Biliary Cirrhosis

    Complications from Primary Biliary Cirrhosis can include hypersplenism (enlargement of the spleen), hepatic encephalopathy (confusion or coma resulting from liver failure)[disability-benefits-help.org] Twenty four hour urine demonstrated a low renal fractional tubular reabsorption of phosphate, increased fractional excretion of uric acid and generalized aminoaciduria.[ncbi.nlm.nih.gov] Jaundice (30 -70 %) -Acute cholangitis - relatively rare (5-25%) symptoms secondary to biliary cirrhosis: -portal HTN -liver failure Advanced liver disease -ascites, variceal[quizlet.com]

  • Diabetic Enteropathy

    Look for signs of chronic liver disease (eg, jaundice, splenomegaly, prominent veins on the abdomen).[patient.info] […] risk of acute coronary ischaemia Autonomic dysfunction: Increased sympathetic nervous system activity Type 2 diabetes Uric acid levels 50% higher with neuropathy than without[neuromuscular.wustl.edu] Typical symptoms of biliary colic include intermittent right upper abdominal pain, jaundice, or pancreatitis.[journal.diabetes.org]

  • Hemolytic Anemia due to a Disorder of Glycolytic Enzymes

    spleen (splenomegaly) Gallstones How is PK deficiency diagnosed?[agios.com] However, inosine, which is a naturally occurring substance, increases plasma uric acid levels ( 38 ).[nature.com] jaundice and episodes of red/ dark urine Venous thrombosis in unusual locations (e.g., hepatic, cerebral, abdominal veins) Vasoconstriction : headache, pulmonary hypertension[amboss.com]

  • Wilson Disease

    acid levels Tissue sample through surgical biopsy of the liver show increased levels of copper (greater than 250 mcg/g dry weight) Physical examination may show signs of[dermnetnz.org] Other symptoms may include: Jaundice Nausea, loss of appetite Vomiting blood Difficulty speaking, swallowing, walking Tremors in hands and arms Muscle rigidity Skin rash Enlarged[columbiasurgery.org] A 15 year old girl presented to an internal medicine ward with a two day history of jaundice and intermittent, high grade fever.[researchgate.net]

  • Pericholangitis

    Signs and symptoms that may appear as the disease progresses include: Pain in the upper right part of the abdomen Fever Chills Night sweats Enlarged liver Enlarged spleen[mayoclinic.org] acid stones Migratory arthritis Sacroiliitis and ankylosing spondylitis Erythema nodosum and uveitis Complications Toxic megacolon Adenocarcinoma of the colon (1-16%) Increased[learningradiology.com] Clinically, this condition usually manifests with chronic intermittent obstructive jaundice. Abdominal pain, pruritus, fatiguability and fever are variably present.[sonoworld.com]

  • Refractory Megaloblastic Anemia

    […] degree of in effective erythropoiesis · Haptoglobins, Uric acid and alkaline phosphatase levels – Decreased. · Serum methylmalonate and homocystein levels - Vitamin B-12[sites.google.com] Examples include causesof splenomegaly, indications for splenectomy, differential diagnosis of normocytic anemia,macrocytic anemia, hypochromic anemia, thrombocytopenia, bone[books.google.de] He has a fever and you note jaundice. You order an ultrasound of his abdomen and find multiple gallstones. Lab results: Hct .36 L/L; Hgb 120 g/L. PBS at right.[med-ed.virginia.edu]

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