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819 Possible Causes for Enlargement of the Spleen, Leukopenia

  • Infectious Mononucleosis

    Leukopenia and thrombocytopenia are not uncommon.[] Enlargement of the spleen Mononucleosis may cause enlargement of the spleen.[] If the spleen is enlarged, the patient may complain of tenderness to palpation.[]

  • Hypersplenism

    Unfortunately, these patients may become intolerant to this therapy when it is complicated by hypersplenism with leukopenia and/or thrombocytopenia.[] Infections: There is enlargement of the spleen in acute pyogenic infection. In septicemia, the spleen is enlarged and called septic spleen.[] A big spleen can cause anaemia, thrombocytopenia and/or leukopenia just by being that massive.[]

  • Gaucher Disease

    Decreased platelet counts (thrombocytopenia) as well as low hemoglobin (anemia) and decreased white blood cell counts (leukopenia) result in easy bruisability and hence black-and-blue[] Mutations in GBA lead to the accumulation of glycosylceramide in the lysosome causing an enlargement of the spleen and the liver and skeletal deformations.[] Haematological abnormalities are common - eg, anaemia, thrombocytopenia and leukopenia.[]

  • Aplastic Anemia

    The regimen has a low incidence of bone marrow suppression, and the incidences of anemia, leukopenia, neutropenia and thrombocytopenia exceeding grade 3 are less than 5%.[] […] liver or spleen Oral thrush (white patches on a red, moist, swollen surface, occurring anywhere in the mouth) The symptoms of aplastic anemia may resemble other blood disorders[] Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infections).[]

  • Ehrlichiosis

    I report a case of tick-borne ehrlichiosis in which the primary presentation suggested an infectious diarrhea, with impressive leukopenia and thrombocytopenia.[] Abdomen: Enlargement of the abdomen may be evident with splenomegaly. The rapid cycling of white blood cells and lymph will lead to the enlargement of the spleen.[] This diagnosis should be considered for patients with fever, leukopenia, thrombocytopenia, and elevated liver enzyme levels.[]

  • Sennetsu Fever

    In addition, in many cases, abnormal laboratory findings may include a decrease in white blood cells (leukopenia) and/or an abnormal increase in the level of certain liver[] […] liver and spleen are some known symptoms of Sennetsu Fever.[] In many cases, abnormal laboratory findings may include a decrease in white blood cells (leukopenia) and/or an abnormal increase in the level of certain liver enzymes (hepatic[]

  • Sjogren's Syndrome

    Blood tests may reveal elevated erythrocyte sedimentation rate and transaminase levels, anemia, leukopenia, eosinophilia, hypergammaglobulinemia, presence of antinuclear antibodies[] There may also be enlargement of the spleen, diminution in white blood cell numbers, Raynaud’s phenomenon, vasculitis (inflammation of vessels) with chronic leg ulcers, a[] High SP-D levels were found with severe glandular involvement, hypergammaglobulinemia, leukopenia, extraglandular manifestations, and positive anti-Ro/La antibodies.[]

  • Familial Myelofibrosis

    Blood counts generally reveal normocytic, normochromic anemia, leukopenia, and thrombocytopenia.[] During fetal development, since bones and thus the bone marrow develop later, therefore, the liver is enlarged during development.[] Enlarged liver and spleen can be palpated, but these organs should also be depicted by sonography.[]

  • Tsutsugamushi Disease

    Leukopenia and abnormal liver function tests are commonly seen in the early phase of the illness.[] Additional symptoms include: enlargement of the spleen, nervous disturbances, delirium, and prostration. Mortality ranges from 6 to 35 percent.[] […] of the spleen, cough, and delirium Pneumonitis or encephalitis Central nervous system (CNS), pulmonary, or cardiac involvement Rarely, acute renal failure, shock, and disseminated[]

  • Mixed Connective Tissue Disease

    At fulfillment of criteria, arthralgia was the most prevalent manifestation (86%), followed by Raynaud's phenomenon (80%), swollen hands (64%), leukopenia/lymphopenia (44%[] Patients may also develop problems swallowing, gastrointestinal difficulties, kidney disease, or enlargement of the spleen or liver.[] After diagnosis — which took a median time of 3.6 years from first symptom onset — 86% had arthralgia, 80% had Raynaud’s phenomenon, 64% had swollen hands, 44% had leukopenia[]

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