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11 Possible Causes for Enlargement of the Spleen, Susceptibility to Hematologic Malignancies Increased

  • Gaucher Disease

    […] platelets (thrombocytopenia), lung disease, and bone abnormalities such as bone pain, fractures, and arthritis [ghr.nlm.nih.gov] (hepatomegaly) and enlarged spleen (splenomegaly[symptoma.com] In addition to the classic manifestations, patients suffer from increased susceptibility to hematologic and nonhematologic malignancies.[ncbi.nlm.nih.gov] People in this group usually bruise easily due to low blood platelets and experience fatigue due to anemia They also may have an enlarged liver and spleen.[ninds.nih.gov]

  • Splenic Subcapsular Hematoma

    Enlargement of the spleen (for example, due to Epstein-Barr virus causing infectious mononucleosis ) makes the spleen more susceptible to injury.[merckmanuals.com] However, splenectomy should be avoided if possible, particularly in children, the elderly, and patients with hematologic malignancy, to avoid the resulting permanent susceptibility[merckmanuals.com] Intraparenchymal hematomas appear broader; irregularly shaped; and hypodense, isodense, or even hyperdense and cause enlargement of the spleen and mass effect.[e-ultrasonography.org]

  • Common Variable Immunodeficiency

    Similarly, enlargement of the spleen is relatively common, as is enlargement of Peyer’s patches which are collections of lymphocytes in the walls of the intestine.[primaryimmune.org] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] Abnormal accumulation of immune cells causes enlarged lymph nodes (lymphadenopathy) or an enlarged spleen (splenomegaly) in some people with CVID.[icdlist.com]

  • Infective Dermatitis Associated with HTLV-1

    No lymph node enlargement or hepato/splenomegaly were found. Another biopsy was performed, consistent with lichenification.[medicaljournals.se] increase the susceptibility to bacterial infections.[htlv.net] […] aggressive forms (acute and lymphomatous), half of the patients show weakness; skin, bone, and multiple visceral lesions; pulmonary infiltrates; hypercalcemia; hepatomegaly; splenomegaly[scielosp.org]

  • Noonan Syndrome

    The liver may be mildly or markedly enlarged, but the spleen is usually markedly increased in size. Abnormally enlarged lymph nodes (lymphadenopathy) can also occur.[rarediseases.org] […] cancer, and notably juvenile hematological malignancies [ 3, 45 ].[doi.org] Twenty-three patients (53%) had splenomegaly, 6 of these with associated hepatomegaly. One patient had a choledochal cyst and a midgut malrotation.[doi.org]

  • Autosomal Dominant Thrombocytopenia 5

    spleen Jaundice.[centogene.com] THC5 is an autosomal dominant disorder, associated with an increased susceptibility to the development of hematologic and solid malignancies.[uniprot.org] […] thalassemia (XLTT) GATA-1 (Xp11) X-L Anemia (mild to nil), unbalanced globin chain synthesis resembling ß-thalassemia, peripheral red cell hemolysis, dysmegakaryocytopoiesis, splenomegaly[ufrgs.br]

  • Common Variable Immunodeficiency Type 4

    Abnormal accumulation of immune cells causes enlarged lymph nodes (lymphadenopathy) or an enlarged spleen (splenomegaly) in some people with CVID.[icdlist.com] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] Similarly, enlargement of the spleen is relatively common, as is enlargement of Peyer’s patches which are collections of lymphocytes in the walls of the intestine.[primaryimmune.org]

  • Common Variable Immunodeficiency Type 11

    Abnormal accumulation of immune cells causes enlarged lymph nodes (lymphadenopathy) or an enlarged spleen (splenomegaly) in some people with CVID.[ghr.nlm.nih.gov] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] Over the years, I started to get other strange symptoms like joint pain, debilitating fatigue, swollen lymph nodes, vision problems, persistent nausea, and enlarged spleen[globalgenes.org]

  • Familial Candidiasis Type 4

    Then, they become seriously ill with fever, swollen lymph nodes, enlarged liver and spleen, and hepatitis.[primaryimmune.org] . • The patients who are on immunosuppressive drug regimens or who have HIV infection, cancer, or hematologic malignancies have an increased susceptibility to oral candidiasis[slideshare.net]

  • Monocytopenia with Susceptibility to Infections

    LYMPHOPROLIFERATIVE SYNDROME 2; LPFS2 Is also known as cd27 deficiency Related symptoms: Autosomal recessive inheritance Anemia Neoplasm Hepatomegaly Splenomegaly SOURCES:[mendelian.co] Most of the patients present with hematological abnormalities (cytopenias, early-onset myeloid malignancies) and an increased susceptibility to opportunistic infections [[bmcpulmmed.biomedcentral.com] Contrary to previous findings from our institution (3), most patients with C. glabrata fungemia in the series re ported here had solid tumors rather than hematologic malignancies[thefreelibrary.com]

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