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17 Possible Causes for Eosinophilia, Larger and Darker Scales on Neck, Elbows and Knees, Palmar Hyperlinearity

  • Atopic Dermatitis

    In older children, atopic dermatitis usually appears in the folds of the elbows, hands and/or knees.[nationaleczema.org] Among patients, reduced level of monomeric filaggrin and NMF correlated with the presence of FLG mutations and clinical phenotypes such as xerosis, palmar hyperlinearity and[ncbi.nlm.nih.gov] We present the case of a 6 year old patient that developed de novo atopic dermatitis, eosinophilia and high levels of total IgE under systemic treatment with tacrolimus.[ncbi.nlm.nih.gov] […] children Flexure lichenification in older children and adults Minor features Eyes Cataracts (anterior subcapsular) Keratoconus Infraorbital folds affected Facial pallor Palmar[aafp.org]

    Missing: Larger and Darker Scales on Neck
  • Pityriasis Circinata

    Circumscribed juvenile type; Affects the elbows and knees presenting follicular plugs surrounded by reddened skin.[hairscientists.org] hyperlinearity; there was no significant association with intrinsic atopic dermatitis.[findzebra.com] In the drug induced form there is no herald patch, individual lesions tend to be violet-red in colour, pruritus is more severe, and eosinophilia may be present.[doi.org] These plaques commonly appear on the outside of the elbows, knees, or scalp. There are also other, less common forms of psoriasis.[healthline.com]

    Missing: Larger and Darker Scales on Neck
  • Ichthyosis

    Palms and soles show accentuated creases and when affecting the palms this sign is referred to as palmar hyperlinearity or as “ichthyosis palms”.[medizin.uni-muenster.de] Signs and symptoms include: skin may appear normal at birth skin gradually becomes dry, rough and scaly, usually before the age of 1 the face and the bends of the elbows and[nhs.uk] Consequently, defects in epidermal barrier function lead to pruritus, a susceptibility to skin infections and AD (often with elevation of total immunoglobulin E levels and eosinophilia[onlinelibrary.wiley.com] Signs and symptoms include: skin may appear normal at birth skin gradually becomes dry, rough and scaly, usually before the age of one the face and the bends of the elbows[nhs.uk]

    Missing: Larger and Darker Scales on Neck
  • Peeling Skin Syndrome Type A

    Psoriasis Share on Pinterest MediaJet/Wikimedia Commons Scaly, silvery, sharply defined skin patches Commonly located on the scalp, elbows, knees, and lower back May be itchy[healthline.com] Palmar and plantar areas are spared or present erythema, slight thickening of the skin or palmar hyperlinearity. An underlying erythroderma is present.[sites.uclouvain.be] A rare autosomal recessive form of congenital, ichthyosis characterised by peeling of skin, erythema, pruritus, short stature, eosinophilia, increased IgE A rare autosomal[medical-dictionary.thefreedictionary.com] Hand-foot syndrome sometimes occurs elsewhere on the skin, such as the knees or elbows. But this is less common.[cancer.net]

    Missing: Larger and Darker Scales on Neck
  • Atopic Cataract

    Eczema flare-ups occur mostly on the face, inside the elbows, behind the knees, and on the hands and feet, though they can happen anywhere, including the eyelids, eyebrows[everydayhealth.com] We found a statistically significant correlation between minor criteria of AD like palmar hyperlinearity and combination of xerosis and Dennie-Morgan fold and the presence[ijdvl.com] Get up-to-date coverage of cell-based condition with brand new chapters on Eosinophilia: Clinical Manifestations and Therapeutic Options and Systemic Mastocytosis.[books.google.com] […] children Flexure lichenification in older children and adults Minor features Eyes Cataracts (anterior subcapsular) Keratoconus Infraorbital folds affected Facial pallor Palmar[aafp.org]

    Missing: Larger and Darker Scales on Neck
  • Ichthyosis-Prematurity Syndrome

    When examined at 2–37 years of age, all patients exhibited skin xerosis, fine or focal scaling (Fig. 1c), palmar hyperlinearity or keratoderma, and frequent occurrence of[medicaljournals.se] Knees, hip and elbow dislocations are common. Thoracic kyphoscoliosis develops in late childhood ...[kegg.jp] Many patients also develop food/respiratory allergies with elevated IgE levels and eosinophilia.[nature.com] […] characterized by premature birth (at gestational weeks 30-32, in general) in addition to thick, caseous and desquamating epidermis, neonatal respiratory asphyxia, and persistent eosinophilia[orpha.net]

    Missing: Larger and Darker Scales on Neck
  • X-Linked Ichthyosis

    The proband (ǁǀ5) is a 9 year-old boy with generalized dry and grey brown scales, without involvement of the palms, soles and face, and no palmar hyperlinearity, accompanied[ijdvl.com] The face, scalp, palms and soles, and hollows of the elbows and knees are usually spared.[rarediseases.org] larger and darker in size with affection of the flexural surface), Congenital non-bullous ichthyosiform erythroderma and Epidermolytic Hyperkeratosis.[indianpediatrics.net] […] keratoderma in LK ( LOR ). ( f ) Palmar hyperlinearity in IV ( FLG ). ( g ) Generalized fine scaling phenotype with concomitant severe erythema in NS ( SPINK5 ). ( h ) Onychoschisis[ncbi.nlm.nih.gov]

    Missing: Eosinophilia
  • Congenital Non-Bullous Ichthyosiform Erythroderma ARCI 10

    When examined at 2–37 years of age, all patients exhibited skin xerosis, fine or focal scaling (Fig. 1c), palmar hyperlinearity or keratoderma, and frequent occurrence of[medicaljournals.se] , knees, dorsa hands and feet Loricrin mutations if deafness is involved: connexin 26 Papillon-Lefevre/Haim-Munk syndrome -diffuse PPK with peridontitis- losing teeth -AR[quizlet.com] A 12-year-old girl from an unrelated Turkish family had fine white scaling on her face, neck, trunk, and flexor surfaces, but larger and darker polygonal scales on the buttocks[bio2rdf.org] IPS is sometimes associated with atopy and eosinophilia, but it is doubtful whether it represents a true syndrome with extracutaneous manifestations.[medicaljournals.se]

  • Parana Hard-Skin Syndrome

    […] of their palmar skin and xerotic fish scale on their legs * Many genetic conditions, such as the large family of ichthyoses (including X-linked ichthyoses, Netherton\'s disease[checkorphan.org] elbow joints (Fig. 1).[myslide.es] NEUROVISCERAL STORAGE DISEASE WITH CURVILINEAR BODIES 257050 : NEUROVISCERAL STORAGE DISEASE WITH VERTICAL SUPRANUCLEAR OPHTHALMOPLEGIA 257100 : NEUTROPENIA, LETHAL CONGENITAL, WITH EOSINOPHILIA[www5.geometry.net] Ankylosis was observed at hip, knee, ankle, shoulder, elbow, wrist and interphalangeal joints ( Fig.1 ) Blood biochemistry did not reveal any abnormalities.[indianpediatrics.net]

    Missing: Larger and Darker Scales on Neck
  • Congenital Non-Bullous Ichthyosiform Erythroderma ARCI2

    hyperlinearity were observed.[ncbi.nlm.nih.gov] Presence of islands of normal skin within exfoliated areas, follicular horny papules present on the dorsal area of the fingers, toes, knees, and elbows with thick scaling[ncbi.nlm.nih.gov] \n\nIchthyosis prematurity syndrome (608649) is a self-improving form of\nichthyosis that includes respiratory complications at birth and\npersistent eosinophilia and is caused[lifemodules.org] Ichthyosis prematurity syndrome ({608649}) is a self-improving form of ichthyosis that includes respiratory complications at birth and persistent eosinophilia and is caused[diseaseinfosearch.org]

    Missing: Larger and Darker Scales on Neck

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