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143 Possible Causes for Eosinophilia, Macrocytosis

  • Pernicious Anemia

    BACKGROUND/PURPOSE: Macrocytosis is defined as having the mean corpuscular volume (MCV) 100 fL.[ncbi.nlm.nih.gov] We describe a case of pernicious anemia (PA) in a patient affected by chronic hepatitis C and macrocytosis during IFN-alpha therapy.[ncbi.nlm.nih.gov] Diagnostic dilemmas could occur when patients with PA present with spuriously normal or high cobalamin levels, normocytic or microcytic anemia, non-anemic macrocytosis, autoimmune[ncbi.nlm.nih.gov]

  • Crohn's Disease

    Marjorie M Walker, Kavita R Aggarwal, Lisa SE Shim, Milan Bassan, Jamshid S Kalantar, Martin D Weltman, Michael Jones, Nicholas Powell and Nicholas J Talley , Duodenal eosinophilia[doi.org]

  • Diphyllobothrium Latum Infection

    […] in appetite (may be increased or decreased) (9) mechanical bowel obstruction (10) vomiting or defecating several proglottids or a whole worm Laboratory findings (1) mild eosinophilia[meducator3.net] Laboratory evaluation was remarkable for a hemoglobin of 14.7, with macrocytosis (MCV 100), and no eosinophilia.[healio.com] Blood examination may reveal a slight leukocytosis with eosinophilia and occasionally a megaloblastic anemia associated with B12 deficiency.[antiinfectivedrugs.com]

  • Chronic Alcoholism

    Investigations taken on admission were as follows: Hb 9.1 g/dl, WCC 16.0 10 9 /l with neutrophilia and no eosinophilia; platelets 448 10 9 /l; Na 128 mmol/l; K 4.8 mmol/l;[academic.oup.com] Alcohol is a common cause of macrocytosis, with a mean corpuscular volume (MCV) of 100-110 fL seen in a majority of patients.[symptoma.com] Alcoholism can also cause mild macrocytosis independent of folate deficiency, due to a direct effect on the bone marrow (common: 90% of alcoholics have MCV of 100-110 even[errolozdalga.com]

  • Myeloproliferative Disease

    Abstract Two children are described who presented at the age of 5 and 7 months with anaemia, a high white cell count with eosinophilia and thrombocytopenia.[ncbi.nlm.nih.gov] Abstract Children with Down syndrome (DS) display macrocytosis, thrombocytosis, and a 500-fold increased risk of developing megakaryocytic leukemia; however, the specific[ncbi.nlm.nih.gov] His complete blood count was remarkable for neutrophilia and, notably, eosinophilia.[ncbi.nlm.nih.gov]

  • Rheumatoid Arthritis

    Abstract Biologics used in the treatment of rheumatoid arthritis (RA) rarely cause eosinophilia.[ncbi.nlm.nih.gov] The following haematologic side effects were included, if reported: cytopenia, macrocytosis, or pancytopenia.[doi.org] All serologic studies were normal except for increased levels of rheumatoid factor and eosinophilia.[ncbi.nlm.nih.gov]

  • Celiac Disease

    Marjorie M Walker, Kavita R Aggarwal, Lisa SE Shim, Milan Bassan, Jamshid S Kalantar, Martin D Weltman, Michael Jones, Nicholas Powell and Nicholas J Talley , Duodenal eosinophilia[dx.doi.org] […] as can be seen in CD can result in atypical findings on the blood smear, and patients with deficiencies of folate and vitamin B 12 may not present with the characteristic macrocytosis[bloodjournal.org]

  • Refractory Megaloblastic Anemia

    Nonalcoholic liver disease and hypothyroidism account for a substantial portion of macrocytosis.[aafp.org] […] unspecified 453.0 I82.0 Budd-Chiari syndrome 286.9 Coagulation defects (coagulopathy), unspecified 286.52 Coagulopathy, autoimmune inhibitors to clotting factors 288.3 D72.1 Eosinophilia[hemonc.org] ,面川 歩,植木重治,竹田正秀,奥山 慎,石井良和,廣川 誠 (2018) 当院の臨床分離大腸菌における世界流行系統ST131-fimH30の検出 2) 奥山 慎,嵯峨知生 (2018) 急性腎障害を併発した菌血症の予後検討 第67回日本アレルギー学会学術大会,6月,東京 1) 植木重治 (2018) 管腔内好酸球増多 (luminal eosinophilia[med.akita-u.ac.jp]

  • Chronic Generalized Exfoliative Dermatitis

    Blood count may show anaemia , white cell count abnormalities, and eosinophilia .[dermnetnz.org] […] occasional islands of sparing. 9 CLINICAL MANIFESTATIONS 10/17/2013 Onset Organ involvement (eg, hepatitis, nephritis, pneumonia) may occur in DRESS (drug reaction with eosinophilia[slideplayer.com] Laboratory investigations demonstrated thrombocytosis, eosinophilia, elevated ESR, anemia, leukocytosis, abnormal liver functions, and hypoalbuminemia [Table 2].[astrocyte.in]

  • Congenital Intrinsic Factor Deficiency

    Eosinophilia allergic hereditary idiopathic secondary Eosinophilic leukocytosis Excludes: Löffler's syndrome (518.3) pulmonary eosinophilia (518.3) 288.4 Hemophagocytic syndromes[theodora.com] Anaemia and macrocytosis (enlarged red blood cells) are known symptoms of Pernicious Anaemia.[stichtingb12tekort.nl] Later, there is both macrocytosis and mild to severe anemia, depending on the duration and severity of the deficiency.[basicmedicalkey.com]

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