Eosinophilic Inclusions: Causes & Reasons

Possible Causes for Eosinophilic Inclusions

Fatal Infantile Hypertonic Myofibrillar Myopathy

inclusions - EMG shows increased insertion activity and fibrillation Respiratory - Respiratory insufficiency, progressive - Weak cry - Apneic episodes - Respiratory failure [mnglabs.com]

Tissue - Endomysial fibrosis - Rigidity - Muscle biopsy shows dystrophic changes - Granular deposits in the sarcomeres - Stiffness - Z-band streaming - Muscle hypertonicity - Eosinophilic [mnglabs.com]

Neuronal Intranuclear Inclusion Disease

Neuronal intranuclear inclusion disease (NIID) is a progressive, usually fatal degenerative neurologic condition characterized by eosinophilic, intranuclear inclusions in [ncbi.nlm.nih.gov]

Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder with a heterogeneous clinical picture characterized by the presence of eosinophilic intranuclear [ncbi.nlm.nih.gov]

Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder with eosinophilic intranuclear inclusion bodies. [ncbi.nlm.nih.gov]

Contagious Ecthyma

inclusion bodies. [histopathology-india.net]

Eosinophilic inclusion bodies were observed in keratinocytes. [scielo.br]

Histological examination showed the presence of inflammatory cellular infiltrates and typical eosinophilic intracytoplasmatic inclusion bodies in epithelial cells. [ncbi.nlm.nih.gov]

Herpes Simplex Esophagitis

Biopsy from these ulcers revealed intranuclear eosinophilic inclusion bodies and multinucleated epithelial giant cells [Figure 2]. [jdeonline.in]

Microscopy will reveal a unique picture of herpes infection like acute inflammation, multinucleated giant cells with ground glass nuclei, as well as eosinophilic inclusions [symptoma.com]

Biopsy from these ulcers revealed intranuclear eosinophilic inclusion bodies and multinucleated epithelial giant cells suggestive of herpetic esophagitis. [jdeonline.in]

Disseminated Cytomegalovirus Infection

Histology showed several voluminous eosinophilic intranuclear inclusions of probable viral nature in endothelial cells, histiocytes in lung parenchyma ( Fig. 1 A and B), in [bjid.org.br]

inclusions. [med.cmu.ac.th]

Large cells with eosinophilic intracytoplasmic and intranuclear inclusion bodies (owl's eye cells) were observed in the vascular endothelium (Figure 2). [symbiosisonlinepublishing.com]

Keratitis Disciformis

inclusion bodies Viral culture Immunohistochemistry looking for herpes simplex viral antigens Polymerase chain reaction (PCR) assay [3] See Workup for more detail. [emedicine.medscape.com]

Tzanck Smear Papanicolaou or Giemsa stains of corneal smears are examined for the presence of multinucleated giant cells and intranuclear eosinophilic inclusion bodies (Cowdry [aao.org]

[…] can be made using the following [2] : Giemsa stain - Scrapings of the corneal or skin lesions show multinucleated giant cells Papanicolaou stain - This shows intranuclear eosinophilic [emedicine.medscape.com]

Familial Encephalopathy with Neuroserpin Inclusion Bodies

The inclusions are eosinophilic (Figure 1, A-D▶ ; Table 2▶ ) and are strongly and uniformly stained by the PAS method (Figure 1E)▶. [ncbi.nlm.nih.gov]

The principle neuropathological finding is the presence of round, eosinophilic, periodic acid/Schiff reagent (PAS)-positive, but diastase-resistant neuronal inclusion bodies [ncbi.nlm.nih.gov]

Numerous, eosinophilic, sharply defined, round-to-oval inclusion bodies of variable size (approximately 5–50 μm) are scattered throughout the deeper layers of the cerebral [ncbi.nlm.nih.gov]

Petrous Apex Meningioma

The tumor cells demonstrate indistinct cell borders, abundant pale eosinophilic cytoplasm, oval nuclei with fine granular chromatin and focal intranuclear inclusions. [radiopaedia.org]

Conn's Adenoma

inclusions treated with spironolactone) Black adenomas: Have dark brown/ black color due to the presence of lipofuscin pigment (image D) ; may be associated with primary [auanet.org]

[…] intracytoplasmic inclusion with laminated, scroll-like appearance in zona glomerulosa ( Lack: AFIP Atlas of Tumor Pathology, Series 4, 2007 ) Frequency in ACA correlates [pathologyoutlines.com]

[…] foci of myelolipoma, manifested by the presence of bone marrow elements Variations: Aldosterone-omas: Golden yellow color with targetoid "spironolactone" bodies (lamellated eosinophilic [auanet.org]

Epidermolytic Acanthoma

Pathologic examination demonstrated acanthosis, hyperkeratosis, cytoplasmic vacuolization, coarse keratohyalin granules, and eosinophilic inclusions. [ncbi.nlm.nih.gov]

inclusions[2,11,12]. [ncbi.nlm.nih.gov]

EHK is defined by keratinocytes in the granular and spinous layers that have reticular degeneration, perinuclear vacuolation, coarse keratohyalin granules, and perinuclear eosinophilic [ncbi.nlm.nih.gov]

Rhabdoid Meningioma

Rhabdoid cells show abundant eosinophilic cytoplasm, cytoplasmic hyaline inclusions, and eccentric nuclei 4. [radiopaedia.org]

[…] cytoplasm, cytoplasmic hyaline inclusions, eccentric nuclei Stout processes consistent with meningioma; however distinct cell borders Often vesicular nuclei with prominent [pathologyoutlines.com]

[…] pseudoinclusions May have brain invasion Often increased mitotic activity (greater than 4/10 HP) May have papillary features Cytology description Rhabdoid cells with abundant eosinophilic [pathologyoutlines.com]

Bizarre Leiomyoma

[…] nucleoli surrounded by perinucleolar halos Rhabdoid / eosinophilic cytoplasmic inclusions May include multinucleated cells and cells with bizarre nuclei Mitotically active [pathologyoutlines.com]

[…] deficient leiomyoma: Alveolar edema Staghorn or hemangiopericytoma-like vessels Chain-like growth of tumor cells Spindle or epithelioid cells with ovoid nuclei and prominent eosinophilic [pathologyoutlines.com]

Syringitis

Herpesvirus infection may be diagnosed histopathologically by the presence of ballooned, acantholytic, and multinucleated keratinocytes; intranuclear eosinophilic viral inclusions [ohsu.pure.elsevier.com]

Methylphenyltetrahydropyridine

inclusion Secondary parkinsonism loss or interference with the action of dopamine in the basal ganglia due to idiopathic degenerative diseases, drugs, or exogenous toxins [medbullets.com]

inclusion bodies. [karger.com]

Firstly, according to most published reports, pigmented nuclei such as locus coeruleus have been spared, except in the SNpc, Secondly, the eosinophilic intraneuronal inclusions [neurodegeneration.uni-goettingen.de]

Anhaptoglobinemia

A liver biopsy showed bridging fibrosis, pale eosinophilic intracytoplasmic hepatocellular inclusions and enlarged endoplasmic reticulum cisternae in the hepatocytes. [cegat.com]

Subacute Sclerosing Panencephalitis

inclusion bodies are present in the cytoplasm nuclei of neurons and glial cells. [medical-dictionary.thefreedictionary.com]

Brain tissue biopsy showed histologic evidence of encephalitis with eosinophilic intranuclear inclusion bodies (Cowdry Type A and B), intracytoplasmic inclusion bodies, perivascular [ncbi.nlm.nih.gov]

Lab tests showing eosinophilic inclusion bodies in the cytoplasm and nuclei of neurons and glial cells. Lab tests showing marked elevation in CSF immunoglobulin. [secure.ssa.gov]

Alexander Disease

The main pathologic feature of AxD is the presence of Rosenthal fibers (RFs), homogeneous eosinophilic inclusions found in astrocytes. [ncbi.nlm.nih.gov]

Abstract Alexander disease (AxD) is a rare neurodegenerative disorder characterized pathologically by the presence of eosinophilic inclusions known as Rosenthal fibers (RFs [ncbi.nlm.nih.gov]

Histologically, Alexander disease is characterized by Rosenthal fibers, homogeneous eosinophilic inclusions in astrocytes. [uniprot.org]

Measles Pneumonia

Histopathologically, measles giant cells had nuclear and cytoplasmic eosinophilic inclusion bodies with some differences in appearance. [ncbi.nlm.nih.gov]

Giant cells contain both intracytoplasmic and intranuclear, eosinophilic inclusion bodies. [histopathology-india.net]

Pulmonary parenchyma shows consolidation with large number of syncytial giant cells containing both intracytoplasmic and intranuclear, eosinophilic inclusion bodies. [histopathology-india.net]

Atypical Teratoid Rhabdoid Tumor

inclusions Eccentrically located nuclei containing vesicular chromatin Prominent eosinophilic nucleoli Cytoplasm is granular Primitive neuroectodermal component is most common [pathologyoutlines.com]

Figure 3A: Malignant cells with eccentric nuclei and eosinophilic cytoplasmic inclusions (arrows), HE x20. [medcraveonline.com]

Histologically, the tumor specimen had many rhabdoid cells with prominent nuclei and eosinophilic cytoplasmic inclusion. It showed mitosis and necrosis. [ncbi.nlm.nih.gov]

Myofibroblastoma of the Breast

[…] glassy cytoplasm, single or multiple prominent nucleoli which may be eccentrically placed, binucleation, sharp cell borders, eosinophilic intracytoplasmic inclusions (Histopathology [pathologyoutlines.com]

[…] entrapping glandular tissue Myxoid: stellate and spindle cells in abundant myxoid stroma (Histol Histopathol 2016;31:1) Deciduoid: large round, polygonal cells with abundant eosinophilic [pathologyoutlines.com]

Nemaline Myopathy Type 5

Abstract The nemaline myopathies are characterized by weakness and eosinophilic, rodlike (nemaline) inclusions in muscle fibers. [wwww.unboundmedicine.com]

The nemaline myopathies are characterized by weakness and eosinophilic, rodlike (nemaline) inclusions in muscle fibers. [uniprot.org]

VL - 67 IS - 4 N2 - The nemaline myopathies are characterized by weakness and eosinophilic, rodlike (nemaline) inclusions in muscle fibers. [wwww.unboundmedicine.com]

Mediastinal Neurofibroma

Schwannomas with ancient change exhibit atypical cells with large hyperchromatic and frequently multilobed nuclei with occasional eosinophilic inclusions (Figure 4). [med.amegroups.com]

Central Epithelioid Sarcoma

[…] cytoplasm and prominent vesicular nuclei and scattered rhabdoid cells with hyaline intracytoplasmic inclusions displacing the nucleus eccentrically FIGURE 3 Epithelioid and [scielo.br]

[…] elevated, infiltrated edges; the second, a plaque, is reddishpurple with a fibrous consistency and 4 cm in diameter FIGURE 2 Epithelioid cells with moderate pleomorphism, eosinophilic [scielo.br]

Massive Hepatic Necrosis

The liver showed typical eosinophilic intranuclear inclusions and herpesvirus virions were demonstrated by electron microscopy. [ncbi.nlm.nih.gov]

PATHOLOGIC FEATURES Herpes hepatitis: nonzonal coagulative necrosis, eosinophilic intranuclear inclusions surrounded by halo (Cowdry Type A), multinucleated cells with molding [demosmedical.com]

[…] cytoplasmic inclusions in degenerating hepatocytes Neutrophilic reaction – accumulate around degenerating hepatocytes (“satellitosis”) Fibrosis – (+) activation of sinusoidal [slideshare.net]

Herpes Simplex Keratitis

inclusion bodies Viral culture Immunohistochemistry looking for herpes simplex viral antigens Polymerase chain reaction (PCR) assay [3] See Workup for more detail. [emedicine.medscape.com]

Cardioneuromyopathy with Hyaline Masses and Nemaline Rods

BUNINA BODIES: Small beaded eosinophilic inclusions 2-5 um in diameter seen in the cytoplasm of motor neurons in motor neuron disease. [sites.google.com]

AFAM is a congenital condition, often rap-Figure 1 Desminopathies: (A) eosinophilic inclusions (arraggregates of desmin within muscle fibers and beneathgranulofilamentous [docslide.us]

[…] pallor (central chromatolysis) = ↑ protein synthesis and axonal sprouting manifestation of aging ( lipofuscin ), disorders of metabolism (storage material), viral diseases ( inclusion [brainscape.com]

Secondary Myopathy

Muscle biopsy revealed non-selective fibre atrophy and numerous eosinophilic inclusions surrounded by asophilic granules. [eprints.soton.ac.uk]

inclusions Polymyositis Proximal Variable, increased incidence with age Interstitial lung disease, disordered GI motility; overlap with rheumatologic diseases more common [aafp.org]

Overlap syndrome with other connective tissue disease DDx. of polymyositis: Chronic weakness: Dermatomyositis Inclusion body myositis Motor neuron disease Spinal muscular [learningneurology.com]

Rectal Biopsy

eosinophilic granules. [ncbi.nlm.nih.gov]

Neuronal intranuclear hyaline inclusion disease is a neurodegenerative disorder of childhood characterized by eosinophilic intranuclear inclusions and neuronal loss throughout [ncbi.nlm.nih.gov]

Discrete eosinophilic intranuclear inclusions, diagnostic of a disease known as neuronal intranuclear inclusion disease, were found in the submucosal ganglion cells. [ncbi.nlm.nih.gov]

Acute Retinal Necrosis

[…] intranuclear inclusions in retinal cells, retinal necrosis, and retinal arteritis.[6] Herpes group of viruses were noted in all the layers of the involved retina using electron [ncbi.nlm.nih.gov]

[…] retinal detachment in ARN reducing the rates for surgical success.[5] The breaks may be located posteriorly as well as peripherally.[5] Histopathology Histology demonstrates eosinophilic [ncbi.nlm.nih.gov]

Molluscum Contagiosum

A biopsy specimen demonstrated lobulated epidermal growth consisting of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies. [ncbi.nlm.nih.gov]

Large numbers of intracytoplasmic eosinophilic inclusions were observed in the keratinocytes [Figure 1] and [Figure 2]. The diagnosis of molluscum contagiosum was made. [mjdrdypu.org]

inclusions containing virus particles) in keratinocytes of stratum spinosum and granulosum Epidermal lobular acanthosis with inverted epidermal hyperplasia Microscopic (histologic [pathologyoutlines.com]