Possible Causes for Eosinopenia & Vacuolated Monocytes Chronic Myelomonocytic Leukemia A - Presence of blastic cells in peripheral blood; B and C - Vacuolated monocytes with lobular or nuclear chromatin alterations and the presence of young cells of monocytic [ncbi.nlm.nih.gov] monocytes with irregular nuclei, and giant and hypogranular platelets (Figure 1). [scielo.br] As previously demonstrated, the patient presented granulocytes with dysplastic characteristics, such as hypogranular neutrophils and hypersegmented nuclei; vacuolated monocytes [ncbi.nlm.nih.gov] Holoprosencephaly - Recurrent Infections - Monocytosis […] with vacuoles monocytes show impaired motility Head And Neck Face: sloping forehead dysmorphic facies Skin Nails Hair Skin: recurrent skin infections Head And Neck Ears: [malacards.org] Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units. Crit Care ; 2008; 12(2):R59. [doctorlib.info] […] thrive Genitourinary Internal Genitalia Male: cryptorchidism Skeletal Hands: brachydactyly tapering fingers Immunology: recurrent infections monocytosis abnormally large monocytes [malacards.org] Acute Infectious Lymphocytosis “Of course, it’s always important to distinguish acute promyelocytic leukemia from acute monocytic leukemia, which has more abundant cytoplasm,” with vacuoles and faint granules [captodayonline.com] An abosulte decrease in the number of circulating basophils may occur with the same conditions that lead to eosinopenia. [health.auckland.ac.nz] Other cells lines such as lymphopenia, monocytopenia, eosinopenia, and basopenia are not uncommon, but will not be discussed further. [antimicrobe.org] Chronic Eosinophilic Leukemia […] peripheral blood eosinophilia ≥1.5 x 10 3 /μL Eosinophils may be morphologically abnormal May have nuclear enlargement, hyper or hyposegmentation Cytoplasmic clearing or vacuolation [surgpathcriteria.stanford.edu] However, there are some conditions that can cause a low level of eosinophils, which is known as eosinopenia. An example of this is drunkenness. [medicalnewstoday.com] […] currently on-going, addressing the optimal dosing interval between mepolizumab infusions, as well as long-term side effects associated with treatment itself and prolonged eosinopenia [ojrd.biomedcentral.com] Adrenal Cortex Hormone Hyperkalemia Hypoglycemia Hypercalcemia Leukocytosis Elevated BUN Eosinophilia Possible acidosis Cushing syndrome Hypernatremia Hypokalemia Hyperglycemia Lymphocytopenia Eosinopenia [journals.lww.com] Childhood Hodgkin Lymphoma Hodgkin's disease, also known as Hodgkin lymphoma is a type of malignant lymphoma, representing approximately 7 percent of childhood cancers. It is seldom found in infants, but more frequent in the 15- to 19-year-old group. The malignant clone, the Reed-Sternberg cell confers unique behavior to this type of[…] [symptoma.com] Pituitary Cushing Syndrome Aggressive pituitary tumours causing Cushing's Disease are very rare, difficult to treat, and usually resistant to conventional therapy. There is growing evidence for the use of temozolomide (TZM), an alkylating chemotherapeutic agent, as first line chemotherapy in tumours resistant to repeated neurosurgery,[…] [ncbi.nlm.nih.gov] Pelger-Huet Anomaly The vacuolated larger cell on the left is an activated monocyte. [hematologylearning.weebly.com] Decreased Amounts of Eosinophils Acute infections, burns, stress reactions, Cushing's syndrome, use of steroids, and leukocytosis can all result in eosinopenia. [hematologylearning.weebly.com] […] in activated monocyte Vacuolization in active monocyte Neutrophilic vacuolization is typically seen with toxic granulation, which may indicate serious bacterial infection [hematologylearning.weebly.com] Acute Myeloid Leukemia with 11q23 Abnormalities Promonocyte Slightly condensed nuclear chromatin; Variably prominent nucleoli Abundant finely granular blue/gray cytoplasm that may be vacuolated Very monocytic appearance [slideshare.net] Monocytopenia Granulocytes + -cytosis : granulocytosis ( Neutrophilia, Eosinophilia, Basophilia ) - -penia : Granulocytopenia/agranulocytosis ( Neutropenia / Kostmann syndrome, Eosinopenia [wikidoc.org] […] or trisomy 11 Microscopic (histologic) description 20%+ blasts / blast equivalents (monoblasts / monocytes) in peripheral blood or bone marrow, usually myelomonocytic or monocytic [pathologyoutlines.com] Leukopenia […] obliterate leukocyte population e.g. chemotherapy or radiotherapy It can be subdivided according to the white cell population that is (most) affected: neutropenia lymphopenia eosinopenia [gpnotebook.com] The mechanism of glucocorticoid eosinopenia; contribution to the physiology of eosinophile granulocytes. [pubmedcentral.nih.gov] Abstract Therapeutic doses of corticosteroids frequently induce eosinopenia; however, the mechanism(s) involved remain obscure. [pubmedcentral.nih.gov] Drug-induced Neutropenia #2 Agranulocytosis = neutropenia, eosinopenia, basopenia, or any combination. Neutropenia = neutropenia #3 Yeah, agree with seminoma. [forums.studentdoctor.net] Eosinopenia and basophilopenia Eosinopenia may be associated with the following: Acute bacterial infection Glucocorticoid administration Physical stress Thymoma Decreased [emedicine.medscape.com] If someone told me a patient was experiencing agranulocytosis, I'd assume mandatory neutropenia, then +/- eosinopenia/basopenia, even though it could technically be any or [forums.studentdoctor.net] Eosinophilopenia Two chemotaxins of allergic inflammation, histamine and the tetrapeptide valine-glycine-serine-glutamic acid, did not cause significant eosinopenia. [jci.org] Eosinopenia of acute infection: Production of eosinopenia by chemotactic factors of acute inflammation. [eosinofilos.com] Table 1 Comparison of Baseline Demographic and Comorbidity Data Between Eosinopenia and Non-eosinopenia Groups Table 2 Comparison of Clinical Expression Between Eosinopenia [dovepress.com] Lathosterolosis Severe Congenital Neutropenia Myelogram is characteristic: only fissile neutrophil cells, promyelocytes and / or myelocytes are retained, the number of eosinophils and monocytes is increased. [m.iliveok.com] […] disease P= Parasitic infections What range of absolute basophil count would qualify a patient to be basophilic greater than 200 basophils Is it possible to have basopenia or Eosinopenia [quizlet.com] In promyelocytes, there are atypical nuclei, large azurophilic granules and vacuoles in the cytoplasm. Without special treatment, patients died before 2-3 years. [m.iliveok.com] Mazzotti Reaction Peripheral blood eosinopenia and neutrophilia also correlated with intensity of infection and appeared to reflect the accumulation of degranulating eosinophils around “mobilized [scinapse.io] Agranulocytosis […] following terms can be used to specify the type of granulocyte referenced: Inadequate numbers of neutrophils: neutropenia (most common) Inadequate numbers of eosinophils: eosinopenia [en.wikipedia.org] 2+ Year Member Joined: Aug 9, 2014 Messages: 1,981 Likes Received: 1,014 Status: Medical Student Agranulocytosis = neutropenia, eosinopenia, basopenia, or any combination. [forums.studentdoctor.net] If someone told me a patient was experiencing agranulocytosis, I'd assume mandatory neutropenia, then +/- eosinopenia/basopenia, even though it could technically be any or [forums.studentdoctor.net] Autosomal Recessive Myeloproliferative Disease […] particularly when sample sits - Numerous small mitochondria in gray cytoplasm - Complex golgi zone - produces granules - Lysosomal granules - Move by undulating pseudopods Monocyte [brainscape.com] […] syndrome) • Skin diseases (e.g., dermatitis herpetiformis) • Tropical eosinophilia • Malignant myeloproliferative disorders • Certain infections (e.g., scarlet fever) • Eosinopenia [slideshare.net] […] mononuclear phagocytic cells - Small (14 - 20u) to large (20 - 30u) - Nucleus: Reniform, fine chromatin, no nucleolus - Cytoplasm: Gray-blue, contains fine lysosomal granules; Vacuoles [brainscape.com] Primary Hypereosinophilic Syndrome Eosinopenia is when levels are low. [medicalnewstoday.com] Generally, bacterial and viral infections cause eosinopenia. [contemporarypediatrics.com] Moreover, although eosinopenia has been frequently observed in hospitalised patients with coronavirus disease 2019 (COVID-19) and has been linked to patient outcomes [32], [err.ersjournals.com] Familial Neutropenia Monocytopenia Granulocytes + -cytosis : granulocytosis ( Neutrophilia, Eosinophilia, Basophilia ) - -penia : Granulocytopenia/agranulocytosis ( Neutropenia / Kostmann syndrome, Eosinopenia [wikidoc.org] […] hypoplastic neutropenia Chronic idiopathic immunoneutropenia in adults Chronic idiopathic neutropenia Disorder of phagocytic cell number Doan-Wiseman syndrome Doan-Wright syndrome Eosinopenia [icd9data.com] Eosinopenia and basophilopenia Eosinopenia may be associated with the following: Acute bacterial infection Glucocorticoid administration Physical stress Thymoma Decreased [emedicine.medscape.com] Leukoerythroblastic Anemia Monocytopenia Granulocytes + -cytosis : granulocytosis ( Neutrophilia, Eosinophilia, Basophilia ) - -penia : Granulocytopenia/agranulocytosis ( Neutropenia / Kostmann syndrome, Eosinopenia [wikidoc.org] […] nodosa, Addison's disease pathogenesis of eosinophilia release of eosinophil chemotactiv factor from mast cells; no sequestering of eosinophils in lymph nodes etiology of eosinopenia [memorize.com] Hypereosinophilic Syndrome 단형 선종으로 이하선, 협 점막, 여성에게 호발한다. acidophilism 산호증, 호산증 뇌하수체의 호산성 세포 선종에 의하여 생기는 상태로 말단 거대증을 일으킨다. eosinocyte 호산구 동의어=eosino eosinopenia 호산구 감소증, 호산구 결핍증 eosinophil adenoma 호산성 [kmle.co.kr] A low number of eosinophils in the blood (eosinopenia) can occur with Cushing syndrome, bloodstream infections (sepsis), and treatment with corticosteroids. [msdmanuals.com] […] familial eosinophilia 가족호산구증가증 orthochromatic erythroblast (⇒orthochromatic normoblast) 호산성적혈모구 tropical eosinophilia 열대호산구증가증 hypereosinophilia 과다호산구증가증 hypoeosinophilia (⇒eosinopenia [kmle.co.kr] Thrombocytopenia Due to Sequestration Tenth Revision, Clinical Modification.D69.59 Other secondary thrombocytopenia and Thrombocytopenia due to sequestration (disorder) D69.42 Sex-linked thrombocytopenia D70.9 Eosinopenia [averbis.com] Renoprival Hypertension […] otalgia, otorrhea, otoplasty, otoscope -pathy disease, anomaly neuropathy, myopathy, osteopathy pelv(i), pelv(o) pelvis pelvimetry, pelvic -penia deficiency, low number eosinopenia [takerx.com] Thyrotroph Pituitary Adenoma […] libido, menstrual changes Signs Thin skin, striae/bruising, central obesity, moon facies, plethora, hypertension, acne, glucose intolerance, neutrophilia, lymphocytopenia, eosinopenia [aafp.org] Lymphocytic Hypereosinophilic Syndrome Eosinopenia is when levels are low. [medicalnewstoday.com] […] currently on-going, addressing the optimal dosing interval between mepolizumab infusions, as well as long-term side effects associated with treatment itself and prolonged eosinopenia [ojrd.biomedcentral.com] A person can be healthy with zero eosinophils, so doctors do not usually consider eosinopenia a matter of concern. [medicalnewstoday.com] Hereditary Neutrophilia […] variation associated with neonates or exercise, lowest in AM, reactive secondary eosinophilia associated with infections with helminthic parasites and allergic disease, eosinopenia [flashcardmachine.com] […] larger and more round than Döhle bodies Term Alterations in relative/absolute numbers of eosinophils Definition can be reactive secondary eosinophilia, diurnal variation, or eosinopenia [flashcardmachine.com] Nitrobenzene Poisoning Among the 14 who succumbed it was found that 13/14(93%) patients had persistent eosinopenia( 7 in 8/14(57%) patients at the end of first week. however in patients who recovered [japi.org] […] ratio with C-reactive protein levels in patients with sepsis Vinu Sarathy, Yogitha C Kempegowda Institute of Medical Sciences, Bangalore Introduction: To establish that eosinopenia [japi.org] […] it was seen that the average eosinophil count increased to 94/cumm and the average n/l ratio was Conclusion: From our study results we can conclude that demonstration of eosinopenia [japi.org] Intestinal Strongyloidiasis Eosinopenia and increased IgE levels have been associated with poor prognosis [ 14, 24 ]. A high index of suspicion is essential for correct diagnosis of S. [omicsonline.org] In patients with chronic and disseminated disease, eosinopenia and low IgE levels have been associated with poor prognosis.1,8 The presence of larvae in stool is diagnostic [gastroenterologyandhepatology.net] In patients with chronic and disseminated disease, eosinopenia and low IgE levels have been associated with poor prognosis. 1,8 The presence of larvae in stool is diagnostic [gastroenterologyandhepatology.net] Lazy Leukocyte Syndrome […] hypoplastic neutropenia Chronic idiopathic immunoneutropenia in adults Chronic idiopathic neutropenia Disorder of phagocytic cell number Doan-Wiseman syndrome Doan-Wright syndrome Eosinopenia [icd9data.com] Neonatal Isoimmune Neutropenia Eosinopenia and basophilopenia Eosinopenia may be associated with the following: Acute bacterial infection Glucocorticoid administration Physical stress Thymoma Decreased [emedicine.medscape.com]