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1,186 Possible Causes for Epicanthal Folds, Preaxial Polysyndactyly, Wide Space Between the First and Second Toe

  • Down Syndrome

    folds, flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21 — called also Down, Down's, trisomy[merriam-webster.com] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[dx.doi.org]

    Missing: Preaxial Polysyndactyly
  • Dubowitz Syndrome

    Ocular problems occur in about 20%: strabismus, blefarophimosis, ptosis, telecanthus and epicanthal folds being the most frequent ones.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Dubowitz syndrome is an autosomal recessive condition characterized by pre- and postnatal growth retardation, eczema, telecanthus, epicanthal folds, blepharophimosis, ptosis[ncbi.nlm.nih.gov]

    Missing: Preaxial Polysyndactyly
  • Kleiner Holmes Syndrome

    His younger brother had preaxial polysyndactyly of the great toes.[omim.org] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first[rarediseases.info.nih.gov]

    Missing: Epicanthal Folds
  • Atelosteogenesis Type 2

    Epicanthal folds, widely spaced eyes, and low-set ears can also be present. Spinal scoliosis and dislocation of the elbows are reported [ Newbury-Ecob 1998 ].[ncbi.nlm.nih.gov] Feet with preaxial polysyndactyly and clubfoot. Sprengel anomaly. Cardiac and genitourinary anomalies.[musculoskeletalkey.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Familial Congenital Nasolacrimal Duct Obstruction

    Hypertelorism with relative telecanthus and epicanthal folds has been described in most cases. 80 Shallow orbits with proptosis and mild down-slanting of the palpable fissure[entokey.com] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] In a literature review they identified the following as the most common ocular abnormalities in Jacobsen syndrome: telecanthus and/or hypertelorism, ptosis, epicanthal folds[genome.jp]

  • Pfeiffer-Palm-Teller Syndrome

    The palpebral fissures were narrow, with epicanthal folds. REFERENCES Pfeiffer, R. A., Palm, D., Teller, W.[omim.org] polysyndactyly syndrome Hamel cerebro-palato-cardiac syndrome Hand-foot-genital syndrome Harrod syndrome Heart-hand syndrome Heart-hand syndrome type 2 Heart-hand syndrome[se-atlas.de] folds, and intellectual deficit.[monarchinitiative.org]

    Missing: Wide Space Between the First and Second Toe
  • Acrocallosal Syndrome

    folds, short nose and mandible and preauricular skin tags, mixed hearing loss, laryngomalacia, and growth and severe motor and mental retardation.[ncbi.nlm.nih.gov] The patient underwent surgery for preaxial polysyndactyly of both hands and feet. The similarity to the Greig syndrome is discussed.[ncbi.nlm.nih.gov] Fig. 3 Figure 4: Radiograph of both foot showing preaxial polysyndactyly.[jemds.com]

    Missing: Wide Space Between the First and Second Toe
  • Polysyndactyly

    Figure 1 Photo 1: showing hyeprtelorism, depressed nasal bridge& medial epicanthal fold. Figure 2 Photo 2: showing polysyndactyly(6 toes) of both the feet.[ispub.com] 42 Bone Search GEO for disease gene expression data for Hallux Varus and Preaxial Polysyndactyly.[malacards.org] Fig. 1 Preaxial polysyndactyly with Delta phalanx.[indianpediatrics.net]

    Missing: Wide Space Between the First and Second Toe
  • Frontonasal Dysplasia

    The main features were severe hypertelorism, downward slanted palpebral fissures, bilateral epicanthal folds, a grossly deformed nose with notched alae nasi, absent nasal[ncbi.nlm.nih.gov] All 5 had a frontonasal malformation of the face and nasal clefting associated with striking symmetrical preaxial polysyndactyly of the feet and variable tibial hypoplasia[doi.org]

    Missing: Wide Space Between the First and Second Toe
  • Ring Chromosome 10

    folds, broad nasal bridge and other facial dysmorphism.[epilepsydiagnosis.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] folds, short thick eyebrows, low-set ears with large lobes, high-arched palate, and short neck.[omim.org]

    Missing: Preaxial Polysyndactyly

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