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157 Possible Causes for Epicanthal Folds, Widely Spaced Nipples

  • Turner Syndrome

    Clinically, patients with Turner syndrome are short, and they have a small chin, prominent folds of skin at the inner corners of the eyes (epicanthal folds), low-set ears,[britannica.com] […] intermamillary distance Wide-spaced nipples Widely spaced nipples Widely-spaced nipples [ more ] 0006610 30%-79% of people have these symptoms Anxiety Excessive, persistent[rarediseases.info.nih.gov] folds can be present; red-green color blindness Ears: Serous otitis media is more common [4] ; the auricles may be posteriorly rotated or low set; hearing loss due to otosclerosis[emedicine.medscape.com]

  • Noonan Syndrome

    ., epicanthal folds, ptosis, ocular hypertelorism), and micrognathia. Individuals with Noonan syndrome often may have either pectus excavatum or pectus carinatum.[symptoma.com] […] intermamillary distance Wide-spaced nipples Widely spaced nipples Widely-spaced nipples [ more ] 0006610 30%-79% of people have these symptoms Abnormal bleeding Bleeding[rarediseases.info.nih.gov] External features were hypertelorism (74%), downward sloping palpebral apertures (38%), epicanthic folds (39%) and ptosis (48%).[nature.com]

  • Cerebro-Facio-Thoracic Dysplasia

    Both affected individuals are members of the same family and have epicanthal folds and hypertelorism.[scinapse.io] Differential Diagnosis [ edit ] Input criteria using London Dysmorphology Database: Hypertelorism; posteriorly rotated ears; epicanthic folds; developmental delay Output:[en.wikibooks.org] Differential Diagnosis Edit Input criteria using London Dysmorphology Database: Hypertelorism; posteriorly rotated ears; epicanthic folds; developmental delay Output: Braegger[psychology.wikia.com]

  • Disorder of Sex Development - Intellectual Disability Syndrome

    ), vertical skin folds between the inner corners of the eyes and the nose (epicanthal folds), a broad nasal bridge, a long upper lip, an abnormally small lower jaw (hypoplastic[rarediseases.org] […] intermamillary distance Wide-spaced nipples Widely spaced nipples Widely-spaced nipples [ more ] 0006610 Percent of people who have these symptoms is not available through[rarediseases.info.nih.gov] The main features are upward-slanted palpebral fissures, a low nasal bridge with epicanthal folds, a small mouth and ears, a single palmar crease (simian crease), a flat nasal[emedicine.medscape.com]

  • Pallister-Killian Syndrome

    folds large ears with lobes that are thick and protrude outward.[en.wikibooks.org] PKS has the following characteristics: low muscle tone facial features that are common to the syndrome-high forehead, broad nasal bridge, wide space between the eyes sparse[pkskids.net] Patients also exhibit a distinctive facial structure, characterized by high foreheads, sparse hair on the temple, a wide space between the eyes, epicanthal folds and a flat[popflock.com]

  • 46,XX Ovarian Dysgenesis-Short Stature Syndrome

    folds, lymphedema of hands and feet, aortic coarctation, renal malformation, osteoporosis, DM, widely spaced nipples, sexual infantilism.[medical-dictionary.thefreedictionary.com] […] without hormonal treatment, average height is 145cm); ovarian dysgenesis (streak ovary); this is the most common cause of primary amenorrhea; infertility; shield chest with widely-spaced[wikilectures.eu] Other physical findings associated with classical forms of gonadal dysgenesis include: epicanthal folds, high arched palate, low nuchal hairline, webbed neck, shield chest[library.med.utah.edu]

  • Ring Chromosome 18

    He had growth and developmental delay, mental and motor retardation, microcephaly, microphtalmia, triangle face, small dysplastic ears, strabismus, epicanthal folds on the[ncbi.nlm.nih.gov] […] includes the TCF4 gene (located at 52,889,562-52,946,887), features of Pitt-Hopkins may be present, including abnormal corpus callosum; short neck; small penis; accessory and wide-spaced[en.wikipedia.org] The fetus had microcephaly, hypertelorism, epicanthal folds, cleft palate, a broad flat nose, simian creases, broad hands, tapered fingers, clubfeet, micropenis, a sacral[ncbi.nlm.nih.gov]

  • Deletion of the Long Arm of Chromosome 18

    Chromosome 18q- syndrome is also often characterized by additional eye (ocular) defects, such as vertical skin folds that may cover the eyes’ inner corners (epicanthal folds[rarediseases.org] folds (29%) Strabismus (20%) Nystagmus (30%) Pale optic discs (23%) Broad nasal bridge (23%) Cleft lip (9%) Nodules at corner of mouth (6%) Palate abnormality (30%) Cleft[en.wikibooks.org] They have short body, flat faces, epicanthic folds (part of skin over the inner corner of the eye – the reason why they are sometimes called “Mongoloid”), small low-set ears[wikilectures.eu]

  • Autosomal-Recessive Non-Lethal Multiple Pterygium Syndrome

    Facial anomalies include hypertelorism, epicanthal folds, flat nasal root, microretrognathism and microstomia, down-slanting palpebral fissures, low-set malformed ears, and[orpha.net] spaced nipples Neurologic Abnormality Failed fusion of posterior neural arches Skeletal Abnormal ossicles Abnormality of ribs Absent or dysplastic patella Anterior clefts[datagenno.com] Facial anomalies (hypertelorism, flattened nose, micrognathia, low set ears and epicanthic folds). Head (brachycephaly with soft bones). Spine (scoliosis may occur).[fetalultrasound.com]

  • Chromosome 18p Deletion Syndrome

    folds * Epicanthal folds * Glaucoma * Graves disease * Growth retardation * Highly arched palate * Hip dislocation * Juvenile diabetes * Large mouth * Low nasal bridge *[checkorphan.org] […] intermamillary distance Wide-spaced nipples Widely spaced nipples Widely-spaced nipples [ more ] 0006610 Wide nasal bridge Broad nasal bridge Broad nasal root Broadened nasal[rarediseases.info.nih.gov] spaced nipples (12%) Hand anomalies Tapered fingers (35%) Proximal thumb (33-65%) with short first metacarpal Transverse palmar creases (23%) High whorl patterns on fingertips[en.wikibooks.org]

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