Epidermal Necrolysis: Causes & Reasons

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Possible Causes for Epidermal Necrolysis

Celecoxib

This is the first case report of toxic epidermal necrolysis due to treatment with celecoxib of which we are aware. [ncbi.nlm.nih.gov]

Toxic epidermal necrolysis (TEN) is a rare disease that is defined by extensive detachment of full-thickness epidermis. [ncbi.nlm.nih.gov]

necrolysis, erythema multiforme and exfoliative dermatitis in patients treated with COX-2 inhibitors. [ema.europa.eu]

Viral Exanthem

necrolysis* Rubella* Toxic shock syndrome (late)* Scarlet fever* Viral exanthem, nonspecific Seborrheic dermatitis Secondary syphilis* Staphylococcal scalded skin syndrome [aafp.org]

Keywords Kawasaki Disease Toxic Epidermal Necrolysis Toxic Shock Syndrome Scarlet Fever Secondary Syphilis These keywords were added by machine and not by the authors. [link.springer.com]

necrolysis* Viral exanthem, nonspecific Erythroderma possible Atopic dermatitis Drug eruption* Psoriasis (plaque psoriasis) Sézary syndrome (i.e., chronic cutaneous T-cell [aafp.org]

Drug Hypersensitivity

The first was a 32-year-old man who developed toxic epidermal necrolysis (TEN) with pulmonary and liver involvement after initiation of lamotrigine therapy for concomitant [ncbi.nlm.nih.gov]

Moxifloxacin was recently reported to induce combined features of drug hypersensitivity syndrome (DHS) and toxic epidermal necrolysis (TEN). [ncbi.nlm.nih.gov]

[…] and accuracy of SCORe of toxic epidermal necrolysis. [doi.org]

Drug Eruptions

BACKGROUND: Toxic epidermal necrolysis (TEN) is a severe drug-induced cutaneous reaction. [ncbi.nlm.nih.gov]

RECENT FINDINGS: In toxic epidermal necrolysis, intravenous human immunoglobulins were expected to inhibit the apoptosis of epidermal cells by blocking the Fas/Fas ligand [ncbi.nlm.nih.gov]

Those with toxic epidermal necrolysis had 100% mortality. [ncbi.nlm.nih.gov]

Drug-Induced Toxic Hepatitis

Nimesulide-induced hepatitis and toxic epidermal necrolysis. [jpgmonline.com]

Toxic Epidermal Necrolysis and Stevens Johnsons Syndrome: Our current understanding. Allergol Int 2006;55:9-16. [ PUBMED ] [ FULLTEXT ] 10. [jpgmonline.com]

Comparison of reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis in association with selective COX-2 inhibitors. Drug Saf 2005;28:917-24. 11. [jpgmonline.com]

Acneiform Drug Eruption

Toxic epidermal necrolysis See separate article Toxic Epidermal Necrolysis. [patient.info]

Intravenous immunoglobulin may be given to treat toxic epidermal necrolysis and systemic steroids may be given in the treatment of hypersensitivity reactions. [aocd.org]

Anticonvulsants, NSAIDs, penicillin, sulfonamides Toxic epidermal necrolysis (TEN) Characterized by large areas (>30% BSA) of loosened, easily detached epidermis that give [merckmanuals.com]

Erythema Multiforme

Abstract Erythema multiforme (EM), Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute bullous disorders associated to different prognosis, mainly [ncbi.nlm.nih.gov]

Toxic epidermal necrolysis and Stevens Johnson syndrome: our current understanding. Allergol Int 2006;55:9-16. [ahcmedia.com]

Dexamethasone pulse therapy for Stevens-Johnson syndrome/toxic epidermal necrolysis. Acta Derm Venereol 2007;87:144-148. [ahcmedia.com]

Dermatitis Vegetans

Seite 20 - Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis. [books.google.de]

الصفحة 20 - Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis. [books.google.com]

necrolysis [Lyell] ( L51.2 ) Bullous disorders L10 ICD-10-CM Diagnosis Code L10 Pemphigus 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes pemphigus neonatorum [icd10data.com]

Impetigo Neonatorum

The incidence of erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis. [books.google.ro]

Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome and erythema multiforme. Arch Dermatol '1993; 129: 92-6. ‏ [books.google.com]

Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome and erythema multiforme. Arch Dermatol '1993; 129: 92-6. ‎ [books.google.ro]

Overlap Syndrome

Homepage Rare diseases Search Search for a rare disease Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome ORPHA:506784 Synonym(s): SJS/TEN overlap syndrome [orpha.net]

Erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis associated with lupus erythematosus. J Am Acad Dermatol 2012;67:417-21. 5. [e-ijd.org]

Stevens-Johnson/TEN overlap syndrome Stevens-Johnson/toxic epidermal necrolysis overlap syndrome Prevalence: - Inheritance: - Age of onset: - ICD-10: L51.8 OMIM: - UMLS: [orpha.net]

Non-Allergic Interstitial Nephritis

*--Not for Stevens-Johnson syndrome/toxic epidermal necrolysis. [aafp.org]

necrolysis, Stevens-Johnson syndrome, erythema multiforme, exfoliative dermatitis, urticaria Frequency not reported : Ecchymosis, purpura, alopecia, photosensitivity, sweating [drugs.com]

It overlaps with and may evolve into the syndrome of toxic epidermal necrolysis (TEN) associated with extensive skin sloughing and a scalded skin appearance. [thefreelibrary.com]

Dermatitis Medicamentosa due to Ingested Drugs

[…] growth factor receptor inhibitors, diuretics Acne-like but no comedones and with sudden onset Toxic epidermal necrolysis (part of erythema multiforme group) Barbiturates, [aneskey.com]

May overlap and progress to toxic epidermal necrolysis. Chelitis, stomatitis, mucosal ulceration, conjunctivitis. Target lesions on hands and feet. [quizlet.com]

Toxic Epidermal Necrolysis Toxic epidermal necrolysis is severe, life threatening cutaneous drug eruption that begins as widespread, tender erythema. [randyjacobsmd.com]

Exfoliative Dermatitis

Immunological mechanisms of epidermal damage in toxic epidermal necrolysis. Curr Opin Allergy Clin Immunol. 2012;12(4):376–82. [clinicalmolecularallergy.biomedcentral.com]

The present case and the others previously reported emphasize the need for greater awareness of the occurrence of adverse cutaneous reactions including toxic epidermal necrolysis [ncbi.nlm.nih.gov]

necrolysis (the scalded skin syndrome): A reappraisal, British Journal of Dermatology, 1979, 100, 1, 69 Wiley Online Library 3 P.F. [onlinelibrary.wiley.com]

Stevens-Johnson Syndrome

necrolysis spectrum toxic epidermal necrolysis Amstutz U, Shear NH, Rieder MJ, Hwang S, Fung V, Nakamura H, Connolly MB, Ito S, Carleton BC; CPNDS clinical recommendation [web.archive.org]

[…] and accuracy of SCORe of toxic epidermal necrolysis. [doi.org]

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are considered a delayed-type hypersensitivity reaction to drugs. [ncbi.nlm.nih.gov]

Muckle-Wells Syndrome

Toxic epidermal necrolysis and Stevens-Johnson syndrome. [ojrd.biomedcentral.com]

Synonyms of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis epidermal necrolysis Subdivisions of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Stevens-Johnson [rarediseases.org]

In some cases, diffuse erythema is the first skin abnormality of toxic epidermal necrolysis. [msdmanuals.com]

Carrington Syndrome

Toxic epidermal necrolysis Synonyms Lyell syndrome, Lyell's syndrome [1] Toxic epidermal necrolysis Specialty Dermatology Symptoms Fever, skin blisters, skin peeling, painful [en.wikipedia.org]

necrolysis: an Asia-Pacific perspective Bernard Yu-Hor Thong Asia Pacific Allergy. 2013; 3(4): 215 [Pubmed] | [DOI] 38 Toxic epidermal necrolysis Robert A. [ijdvl.com]

"Treatment of toxic epidermal necrolysis by burn units: another market or another threat?". [en.wikipedia.org]

Fixed Eruption

Toxic epidermal necrolysis See separate article Toxic Epidermal Necrolysis. [patient.info]

Prognosis of generalized bullous fixed drug eruption: comparison with Stevens–Johnson syndrome and toxic epidermal necrolysis. Br J Dermatol. 2013;168:726–32. [link.springer.com]

Generalized bullous fixed drug eruption (GBFDE) may be confused with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). [siicsalud.com]

Bullous Impetigo

necrolysis. [freethesaurus.com]

2017 2018 2019 Billable/Specific Code Applicable To Ritter's disease Type 1 Excludes bullous impetigo ( L01.03 ) pemphigus neonatorum ( L01.03 ) toxic epidermal necrolysis [icd10data.com]

[…] infection, acantholytic cells in pemphigus, dyskeratotic acantholytic cells and cocci in bullous impetigo, pseudohyphae in candidiasis and necrotic basal cells in toxic epidermal [freethesaurus.com]

Toxic Epidermal Necrolysis

[…] the skin epithelium and mucous membranes Toxic epidermolysis Lyell's Syndrome SJS-TEN Statements Toxic epidermal necrolysis toxic-epidermal-necrolysis Identifiers Sitelinks [wikidata.org]

Toxic epidermal necrolysis is a severe form of Stevens-Johnson syndrome. The condition is called toxic epidermal necrolysis when >30% of the body surface is involved. [symptoma.com]

necrolysis Toxic epidermal necrolysis (TEN) is an acute and severe skin disease with clinical and histological features characterized by the destruction and detachment of [wikidata.org]

Zinc-Responsive Necrolytic Acral Erythema

necrolysis and StevensJohnson syndrome 830 246 Transient acantholytic dermatosis Grover disease 834 247 Trichotillomania 836 248 Tuberculosis and tuberculids 838 249 Urticaria [books.google.com]

It also discusses the theory that low amino acids and high glucagon lead to epidermal protein depletion and necrolysis.) Khanna, VJ, Shieh, S, Benjamin, J. [dermatologyadvisor.com]

- Low amino acid levels may lead to epidermal protein depletion and necrolysis. - Low albumin levels have also been postulated as causative. [slideshare.net]

Staphylococcal Scalded Skin Syndrome

necrolysis (TEN), in that the cleavage site in SSSS is intraepidermal, as opposed to TEN, which involves necrosis of the entire epidermis Images Please click on images to [pcds.org.uk]

Results of a Tzanck smear suggested toxic epidermal necrolysis (TEN), so the infant was emergently transferred to a local children's hospital with burn unit capabilities for [ncbi.nlm.nih.gov]

Staphylococcal scalded skin syndrome (SSSS) and toxic epidermal necrolysis (TEN) both present with acute onset, high morbidity and significant mortality. [ncbi.nlm.nih.gov]

Symblepharon

necrolysis (TEN). [ncbi.nlm.nih.gov]

Therefore, we have analyzed 84 patients w… PMC Free Full TextPMC Free PDF Sutureless Amniotic Membrane Transplantation in a Pediatric Patient with Acute Toxic Epidermal Necrolysis [unboundmedicine.com]

necrolysis Thus, presentation may be dependent upon the etiology. [visualdx.com]

Cyclosporine Toxicity

Prevention of vulvovaginal sequelae in Stevens-Johnson syndrome and toxic epidermal necrolysis. [ncbi.nlm.nih.gov]

Outcome of Stevens Johnson syndrome and toxic epidermal necrolysis treated with corticosteroids. [ijdvl.com]

Figure 1: Extensive blistering of the skin in toxic epidermal necrolysis on admission. [ijdd.in]

Linear IgA Dermatosis

The clinical features resembled that seen in toxic epidermal necrolysis. [ncbi.nlm.nih.gov]

Linear IgA bullous disease presenting as toxic epidermal necrolysis Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse reaction to a drug that presents with widespread [dermnetnz.org]

Kakar R, Paugh H, Jaworsky C: Linear IgA bullous disease presenting as toxic epidermal necrolysis: a case report and review of the literature. [karger.com]

Peeling Skin Syndrome

Toxic epidermal necrolysis causes large areas of peeling skin (affecting over 30% of the body). [msdmanuals.com]

Compare toxic epidermal necrolysis. [medical-dictionary.thefreedictionary.com]

There are also other drugs that can cause Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. [skinassn.org]

Acquired Epidermolysis Bullosa

We report a patient with a spectrum of clinical features simulating toxic epidermal necrolysis, bullous erythema multiforme and later, dermatitis herpetiformis (DH). [ncbi.nlm.nih.gov]

necrolysis ( Fig. 24.3 ). [clinicalgate.com]

necrolysis [Lyell] ( L51.2 ) Bullous disorders L12 ICD-10-CM Diagnosis Code L12 Pemphigoid 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes herpes gestationis [icd10data.com]

Penicillin Poisoning

*--Not for Stevens-Johnson syndrome/toxic epidermal necrolysis. [aafp.org]

Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN): Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but serious allergic reactions [drugs.com]

Lifelong avoidance of a drug is necessary for the rare but severe reactions such as erythema multiforme major or toxic epidermal necrolysis. [mja.com.au]

Chronic Generalized Exfoliative Dermatitis

Immunological mechanisms of epidermal damage in toxic epidermal necrolysis. Curr Opin Allergy Clin Immunol. 2012;12(4):376–82. [clinicalmolecularallergy.biomedcentral.com]

Impact of phenytoin therapy on the skin and skin disease; Stevens-Johnson syndrome, generalised exfoliative dermatitis, toxic epidermal necrolysis... [acronymattic.com]

necrolysis [Lyell] ( L51.2 ) Use Additional code to identify percentage of skin exfoliation ( L49.- ) L00 ) The following code(s) above L26 contain annotation back-references [icd10data.com]

Subacute Cutaneous Lupus Erythematosus

epidermal necrolysis. [medicaljournals.se]

Toxic epidermal necrolysis (TEN) that occurs in SLE patients has been infrequently reviewed. [ncbi.nlm.nih.gov]

Cutaneous side effects of lansoprazole are lichen planus, urticaria, and toxic epidermal necrolysis.( 1, 5 ) Lansoprazole- induced SCLE has been reported in very few studies [archivesofrheumatology.org]

Peeling Skin Syndrome Type 3

Toxic Epidermal Necrolysis (TEN) or blisters which cover the whole body. It is a rare disease, but another reason for skin peeling. [suncoastsalts.com]

Toxic epidermal necrolysis (TEN) shows deeper cleavage below the epidermis. Hubiche T, Bes M, Roudiere L, Langlaude F, Etienne J, Del Giudice P. [emedicine.medscape.com]

Lesions can also be annular or polycyclic GENERALISED PEELING In addition to the Staphylococcal Scalded Skin syndrome, Stevens Johnson syndrome / toxic epidermal necrolysis [pcds.org.uk]