Epidermal Thinning: Causes & Reasons

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Possible Causes for Epidermal Thinning

Reticulate Acropigmentation of Kitamura

Suprapapillary epidermal thinning may also be seen. [idoj.in]

The histopathology of DDD shows characteristic thin branch-like patterns of epidermal downgrowth (summary by {13:Li et al., 2013}). [diseaseinfosearch.org]

 Epidermal atrophy  Elongated thin rete ridges  Increased basal layer pigmentation at tips of rete ridges  Special staining shows increased number of dopa-positive melanocytes [slideshare.net]

Palmoplantar Keratoderma of Sybert

—There is epidermal hyperplasia with hypergranulosis, a thin layer of parakeratosis, and overlying orthokeratosis. [escholarship.org]

Zoon Balanitis

Key histologic features of Zoon balanitis include epidermal thinning, possibly with some superficial erosion. [aafp.org]

thinning help in distinguishing ZB from carcinoma in situ. [wikidoc.org]

Most of the curved vessels are fairly focused due to the epidermal thinning usually encountered in ZB, which makes the dermal vessels fairly closer to the surface and thus [ncbi.nlm.nih.gov]

Skin Atrophy

Moreover, calcipotriol is able to restore betamethasone-impaired HA synthesis in keratinocytes and prevent betamethasone-induced epidermal thinning in minipigs upon treatment [ncbi.nlm.nih.gov]

Histological analysis performed at day 29 showed significant epidermal thinning with topical steroids compared with SDZ ASM 981 1% cream or the vehicle. [ncbi.nlm.nih.gov]

Granulosis Rubra Nasi

Lesional skin biopsy showed epidermal thinning and vascular dilatation of upper and mid-dermal blood vessels and perivascular lymphohistiocytic infiltrate [Figure - 2]. [ijdvl.com]

Sebocystomatosis

The cysts typically have an intricately infolded thin epidermal lining, without a granular layer, incorporating abortive hair follicles and at times sebaceous, eccrine, or [btb.termiumplus.gc.ca]

epidermal strand. [1] Usually begining in adolescence or early adult life, [2] it may be inherited as an autosomal dominant trait, although most cases have no family history [ijdvl.com]

[…] autosomal dominant disorder chiefly affecting males at birth or presenting about the time of puberty, characterized by the development of numerous flesh-colored to yellow epidermal [btb.termiumplus.gc.ca]

Fordyce Angiokeratoma

Histological findings include numerous, dilated, ectatic, thin-walled, congested blood vessels in the papillary dermis with overlying epidermal hyperkeratosis and acanthosis [oatext.com]

Histologically, they are composed of ectatic thin-walled vessels in the superficial dermis with overlying epidermal hyperplasia. [2, 3, 4, 5] "Angiokeratoma" is a broad term [emedicine.medscape.com]

Steroid Atrophy

Moreover, calcipotriol is able to restore betamethasone-impaired HA synthesis in keratinocytes and prevent betamethasone-induced epidermal thinning in minipigs upon treatment [genoskin.com]

Before treatment all patients had very thin skin, severe laxity, purpura and echymoses and teleangiectasia. [llogo.hu]

Epidermal thickness increased from 0.11 to 0.28 mm, dermal thickness from 0.80 to 1.55 mm and skin elasticity from 44% to 74%, while the erythemal index decreased from 0.391 [llogo.hu]

Xerotic Eczema

Key histologic features of Zoon balanitis include epidermal thinning, possibly with some superficial erosion. [aafp.org]

Histopathologic examination revealed epidermal thinning, spongiosis, and a dense subepidermal infiltrate composed of plasma cells and neutrophils. [aafp.org]

Lichen Sclerosus

An excisional biopsy showed epidermal thinning on the left side and invasion of the dermis by a tumor nest on the right side (A) (H&E, original magnification ×10). [mdedge.com]

thinning due to estrogen deficiency but not as a primary therapy of LS. [ncbi.nlm.nih.gov]

REATMENT Hormonal therapy Estrogen is an effective treatment for postmenopausal vulvovaginal atrophy and should be considered in women with dyspareunia, labial fusion, or epidermal [ncbi.nlm.nih.gov]

Angiokeratoma

Within an overall hyperkeratotic and acanthotic epidermis, there were focal areas of lichenoid change and epidermal thinning. [ncbi.nlm.nih.gov]

Condyloma

For epidermal development, combined deficiency of KRAS, HRAS and NRAS was associated with epidermal thinning and a dramatic decrease in proliferation of keratinocytes [ 43 [royalsocietypublishing.org]

Acroosteolysis-Keloid-Like Lesions-Premature Aging Syndrome

[…] lesions that resemble scars, thin hair, proptosis, underdeveloped cheekbones, and marked acro-osteolysis. [unboundmedicine.com]

Scoliosis (in some patients) Hands Acroosteolysis Contractures of fingers Brachydactyly [ EoM Image ] Further information: Morphology of elements Skin Nails Hair Skin Histology Epidermal [mnglabs.com]

Abstract Penttinen syndrome is a distinctive disorder characterized by a prematurely aged appearance with lipoatrophy, epidermal and dermal atrophy along with hypertrophic [unboundmedicine.com]

Striae Distensae

Abstract Striae distensae are dermal atrophic scars with epidermal thinning and decreased collagen and elastic fiber. [ncbi.nlm.nih.gov]

It is theorized striae are caused by rapid expansion of connective tissue with damage resulting in dermal tissue atrophy and overlying epidermal thinning. [aocd.org]

In striae alba, histologic findings include epidermal atrophy; thin, eosinophilic collagen bundles arranged horizontally, which is parallel to surface of the skin as is seen [unboundmedicine.com]

Malignant Neoplasm of the Vulva

An excisional biopsy showed epidermal thinning on the left side and invasion of the dermis by a tumor nest on the right side (A) (H&E, original magnification ×10). [mdedge.com]

Erythroplasia of Queyrat

Key histologic features of Zoon balanitis include epidermal thinning, possibly with some superficial erosion. [aafp.org]

Histopathologic examination revealed epidermal thinning, spongiosis, and a dense subepidermal infiltrate composed of plasma cells and neutrophils. [aafp.org]

Peeling Skin Syndrome

Histopathological examination revealed epidermal separation in stratum corneum, thinning of epidermis, and loss of rete ridges. [ncbi.nlm.nih.gov]

Figure 4: Histopathological figure (H and E stain) ×100 revealed epidermal separation in stratum corneum, thinning of epidermis, and loss of rete ridges. [doi.org]

[…] in stratum corneum, thinning of epidermis, and loss of rete ridges. [ncbi.nlm.nih.gov]

Mucocutaneous Leishmaniasis

Leishman-Donovan bodies were seen on tissue imprints, and histopathology showed epidermal thinning with loss of appendages and dense pandermal infiltrate. [ncbi.nlm.nih.gov]

Hypergonadotropic Hypogonadism - Partial Alopecia

[…] hyperkeratosis, facial features (small mouth, small pinched nose and micrognathia), sparse/absent eyelashes and eyebrows, mineralization defects of the skull, thin dysplastic [ab-y-ss.com]

[…] contracture syndrome is a rare disorder mainly characterized by intrauterine growth retardation, tight and rigid skin with erosions, prominent superficial vasculature and epidermal [genscript.com]

[…] syndrome (LTSCS) [MIM:275210]: Rare disorder mainly characterized by intrauterine growth retardation, tight and rigid skin with erosions, prominent superficial vasculature and epidermal [antibodyplus.com]

Erythema ab Igne

Histopathologic changes are significant for epidermal thinning accompanied by interface dermatitis with vacuolar alteration of the basal cell layer (Figure 2). [dermatologyadvisor.com]

There are slightly dilated, thin-walled blood vessels within the superficial dermis. [escholarship.org]

As lesions progress, the epidermal atrophy becomes more pronounced, resulting in flattening of the rete ridges. [dermatologyadvisor.com]

Lupus Vulgaris

Secondary changes like acanthosis and hyperkeratosis were seen in 11 out of 14 cases (78.5%) and epidermal thinning and atrophy was noted in 1 case [ Figures 7 ]. [ncbi.nlm.nih.gov]

Secondary changes may be superimposed: epidermal thinning and atrophy or acanthosis with excessive hyperkeratosis or pseudoepitheliomatous hyperplasia; acid-fast bacilli are [epathologies.com]

Secondary changes like acanthosis and hyperkeratosis were seen in 11 out of 14 cases (78.5%) and epidermal thinning and atrophy was noted in 1 case [Figure 7]. [idoj.in]

Benign Cephalic Histiocytosis

Histopathological examination revealed mild epidermal atrophy and thinning, dense histiocytic infiltration along with some lymphocytes in the upper and middle dermis. [caod.oriprobe.com]

Halcinonide

Halcinonide Indications / Halcinonide Uses Information Not Available Halcinonide Adverse Reactions / Halcinonide Side Effects Prolonged application causes epidermal thinning [drugsupdate.com]

HALCINONIDE : Prolonged application causes epidermal thinning, contact dermatitis, perioral dermatitis, papular disorder, mild depigmentation; telangiectasia, striae (especially [medidart.com]

Chronic Lichenoid Pityriasis

HISTIOPATHOLOGY-Diffuse from LP by presence of TREATMENT • Focal parakeratosis • Alternating areas of acanthosis and epidermal thinning • Heavier upper dermal infiltrate • [slideshare.net]

/ no granular cell layer, suprapapillary thinning (attenuated layer of epidermal cells above tips of dermal papillae), Munro microabscesses (neutrophils in parakeratotic [pathologyoutlines.com]

[…] servers: Guttate psoriasis Microscopic (histologic) description Parakeratosis without hyperkeratosis, acanthosis with downward elongation of rete ridges (resembles a comb), thin [pathologyoutlines.com]

Chronic Actinic Dermatitis

Epidermal thinning, variable parakeratosis, and diffuse spongiosis can also be seen on microscopy [ 1, 2 ]. [omicsonline.org]

Vulvitis

The biopsy specimen of the lesion revealed epidermal thinning, the absence of a horny and granular cell layer, and the presence of distinctive lozenge-shaped keratinocytes [ncbi.nlm.nih.gov]

Histological features of the condition include the predominant feature of subepidermal plasma cell infiltrates in a band-like pattern, epidermal thinning which is thought [clinicaldermatology.eu]

thinning, presence of distinctive lozenge-shaped keratinocytes with sparse dyskeratosis and spongiosis, and a dense inflammatory infiltrate of (A) T-lymphocytes (CD3+), [ncbi.nlm.nih.gov]

Dowling-Degos Disease Type 2

Histologically, epidermal acanthosis, thin, branch-like, rete ridges, and a tendency for acantholysis and pigmentary incontinence is observed. [orpha.net]

Suprapapillary epidermal thinning may also be seen. [idoj.in]

Histopathological examination from both the samples showed circumscribed foci of epidermal proliferation as thin, elongated rete ridges with antler-like branching at places [ijdvl.com]

Vulvar Dystrophy

[…] and dermal atrophy Thinning of epithelium with blunting / loss of rete pegs Superficial dermal chronic inflammation In late stages, there is band like hyalinization of dermal [pathologyoutlines.com]

Histology There is both epidermal and dermal atrophy (atrophic vulvitis). [med-ed.virginia.edu]

[…] squamous cell carcinoma Clinical images Images hosted on other servers : White epithelium with atrophic labia majora Microscopic (histologic) description Lichen sclerosus Epidermal [pathologyoutlines.com]

Rhinolithiasis

The origin of the rhinolith started with a piece of plant material, lodged in the nose, which was replaced by calcium stearate, leaving some remnants of resistant epidermal [ncbi.nlm.nih.gov]

During subsequent years, thin layers of whitlockite were deposited periodically around the core with the reddish brown bands representing deposition during the dry season [ncbi.nlm.nih.gov]

Arthrogryposis-Hyperkeratosis Syndrome, Lethal Form

There were skin erosions and ﬁs- sures, epidermal hyperkeratosis and dermal thinning on the abdomen, inguinal, axilla, and cervical regions. [myslide.es]

The dermoepidermaljunction is flat, the dermis is thin, and epidermal append-ages are absent or appear miniaturized and immature(16). [docslide.us]

The epidermal rete ridges are flattened and the dermal-hypodermal border is remarkably straight. [cags.org.ae]