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682 Possible Causes for Episodic Muscle Weakness

  • Acute Gastroenteritis

    Hypokalemic periodic paralysis is a condition, characterized by episodic weakness of the skeletal muscle. It may be presented as familial or sporadic (secondary).[ncbi.nlm.nih.gov]

  • Paraparesis

    Periodic paralysis is a muscle disorder that belongs to the family of diseases called channelopathies, manifested by episodes of painless muscle weakness.[ncbi.nlm.nih.gov] Periodic paralysis is classified as hypokalemic when episodes occur in association with low potassium levels. Most cases are hereditary.[ncbi.nlm.nih.gov]

  • Combined Oxidative Phosphorylation Deficiency 15

    The most common clinical manifestations are seizures, hypotonia, ophthalmoplegia, strokelike episodes, muscle weakness, severe constipation, and cardiomyopathy.[merckmanuals.com] Tissues with a high energy demand (eg, brain, nerves, retina, skeletal and cardiac muscle) are particularly vulnerable to defects in oxidative phosphorylation.[merckmanuals.com]

  • Myasthenia Gravis

    Myasthenia gravis involves episodic muscle weakness and easy fatigability caused by autoantibody- and cell-mediated destruction of acetylcholine receptors.[merckmanuals.com] Myasthenia gravis is an autoimmune disorder that impairs communication between nerves and muscles, resulting in episodes of muscle weakness.[merckmanuals.com]

  • Nephrogenic Syndrome of Inappropriate Antidiuresis

    Muscle Weakness, X-Linked Erythropoietic Protoporphyria, X-Linked Dominant External Ophthalmoplegia and Myopia Fabry disease Familial Exudative Vitreoretinopathy, X-Linked[rgd.mcw.edu] […] encephalopathy 9 Early Onset Parkinsonism with Mental Retardation Ectodermal Dysplasia 1, Anhidrotic Ehlers-Danlos Syndrome Type 5 Epidermodysplasia Verruciformis, X-Linked Episodic[rgd.mcw.edu]

  • Tubular Aggregate Myopathy

    Keywords Tubular aggregates STIM1 gene Episodic muscle weakness References 1. Engel WK, Bishop DW, Cunningham GG.[link.springer.com] weakness and by muscle biopsy showing 60–90 % of fibers containing tubular aggregates.[link.springer.com] weakness and by muscle biopsy showing 60–90% of fibers containing tubular aggregates.[link.springer.com]

  • Conn Syndrome

    Conn described a case of a 34 year old female patient who had been complaining of seven years of episodic muscle weakness, muscle spasms and cramping of her hands. Dr.[clinicalcorrelations.org] Patient gave history of episodic proximal muscle weakness of lower limbs over past one year duration often requiring support.[sjkdt.org] Case 2 33 year old lady presented with recurrent episodic muscle weakness of 4 years duration associated with myalgia and backache.[sjkdt.org]

  • Charcot Marie Tooth Disease

    Episodic muscle weakness is the hallmark of a heterogeneous group of disorders known as periodic paralysis.[ncbi.nlm.nih.gov] […] predominant distal muscle weakness and atrophy.[ncbi.nlm.nih.gov] Mitochondrial DNA mutations should be considered in patients with a history of episodic weakness and axonal inherited neuropathy (CMT2).[ncbi.nlm.nih.gov]

  • Cardiac Arrhythmia

    At the start of an episode of muscle weakness, the serum potassium concentration rose from 3.1 to 4.4 mEq/l.[ncbi.nlm.nih.gov] She had atrophy of the proximal muscles and deep tendon reflexes were reduced. Her ECG showed bigeminy with multifocal premature ventricular contractions.[ncbi.nlm.nih.gov]

  • Adrenal Cortex Tumor

    CONN’s Syndrome (hyperaldosteronism) yellow in colour Hypertension (mild to moderate) Hypokalemia (episodic) – muscle weakness, cramping, arrhythmia Headaches Polydipsia,[medatrio.com] […] polyuria (not diagnostic) Blood test done during episode.[medatrio.com]

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