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682 Possible Causes for Episodic Muscle Weakness

  • Acute Gastroenteritis

    Hypokalemic periodic paralysis is a condition, characterized by episodic weakness of the skeletal muscle. It may be presented as familial or sporadic (secondary).[]

  • Paraparesis

    Periodic paralysis is a muscle disorder that belongs to the family of diseases called channelopathies, manifested by episodes of painless muscle weakness.[] Periodic paralysis is classified as hypokalemic when episodes occur in association with low potassium levels. Most cases are hereditary.[]

  • Combined Oxidative Phosphorylation Deficiency 15

    The most common clinical manifestations are seizures, hypotonia, ophthalmoplegia, strokelike episodes, muscle weakness, severe constipation, and cardiomyopathy.[] Tissues with a high energy demand (eg, brain, nerves, retina, skeletal and cardiac muscle) are particularly vulnerable to defects in oxidative phosphorylation.[]

  • Myasthenia Gravis

    Myasthenia gravis involves episodic muscle weakness and easy fatigability caused by autoantibody- and cell-mediated destruction of acetylcholine receptors.[] Myasthenia gravis is an autoimmune disorder that impairs communication between nerves and muscles, resulting in episodes of muscle weakness.[]

  • Nephrogenic Syndrome of Inappropriate Antidiuresis

    Muscle Weakness, X-Linked Erythropoietic Protoporphyria, X-Linked Dominant External Ophthalmoplegia and Myopia Fabry disease Familial Exudative Vitreoretinopathy, X-Linked[] […] encephalopathy 9 Early Onset Parkinsonism with Mental Retardation Ectodermal Dysplasia 1, Anhidrotic Ehlers-Danlos Syndrome Type 5 Epidermodysplasia Verruciformis, X-Linked Episodic[]

  • Tubular Aggregate Myopathy

    Keywords Tubular aggregates STIM1 gene Episodic muscle weakness References 1. Engel WK, Bishop DW, Cunningham GG.[] weakness and by muscle biopsy showing 60–90 % of fibers containing tubular aggregates.[] weakness and by muscle biopsy showing 60–90% of fibers containing tubular aggregates.[]

  • Conn Syndrome

    Conn described a case of a 34 year old female patient who had been complaining of seven years of episodic muscle weakness, muscle spasms and cramping of her hands. Dr.[] Patient gave history of episodic proximal muscle weakness of lower limbs over past one year duration often requiring support.[] Case 2 33 year old lady presented with recurrent episodic muscle weakness of 4 years duration associated with myalgia and backache.[]

  • Charcot Marie Tooth Disease

    Episodic muscle weakness is the hallmark of a heterogeneous group of disorders known as periodic paralysis.[] […] predominant distal muscle weakness and atrophy.[] Mitochondrial DNA mutations should be considered in patients with a history of episodic weakness and axonal inherited neuropathy (CMT2).[]

  • Cardiac Arrhythmia

    At the start of an episode of muscle weakness, the serum potassium concentration rose from 3.1 to 4.4 mEq/l.[] She had atrophy of the proximal muscles and deep tendon reflexes were reduced. Her ECG showed bigeminy with multifocal premature ventricular contractions.[]

  • Adrenal Cortex Tumor

    CONN’s Syndrome (hyperaldosteronism) yellow in colour Hypertension (mild to moderate) Hypokalemia (episodic) – muscle weakness, cramping, arrhythmia Headaches Polydipsia,[] […] polyuria (not diagnostic) Blood test done during episode.[]

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