Episodic-weakness: Causes & Reasons

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Possible Causes for episodic weakness

Cardiodysrhythmic Potassium-Sensitive Periodic Paralysis

Andersen-Tawil syndrome (ATS) is characterized by a triad of: episodic flaccid muscle weakness (i.e., periodic paralysis); ventricular arrhythmias and prolonged QT interval [ncbi.nlm.nih.gov]

However he never reported any episode of muscular weakness. [japi.org]

Episodic weakness is secondary to abnormalities in sarcolemmal excitability due to dysfunctional ion channels. [scielo.br]

Paramyotonia Congenita

Pyridostigmine relieved episodic weakness in a family with paramyotonia congenita resulting from the R1448C mutation in the sodium channel gene. [ncbi.nlm.nih.gov]

episodic weakness. [ncbi.nlm.nih.gov]

A patient with paramyotonia congenita, a related disorder with myotonia and episodic weakness, was studied during treatment with acetazolamide. [ncbi.nlm.nih.gov]

Hyperkalemic Periodic Paralysis

Disappearance of episodic weakness during pregnancy and an increase in myotonia after delivery have not been reported in hyperkalemic periodic paralysis (hyperPP). [ncbi.nlm.nih.gov]

Abstract Hyperkalemic periodic paralysis (hyperKPP) and paramyotonia congenita (PC) are genetic muscle disorders sharing the common features of myotonia and episodic weakness [ncbi.nlm.nih.gov]

Small elevations in serum potassium lead to inactivation of sodium channels, causing episodic weakness or paralysis. [ncbi.nlm.nih.gov]

Familial Periodic Paralysis

RESULTS: The two most common hyperkalemic periodic paralysis (HyperPP) mutations responsible for episodic attacks of weakness or paralysis, T704M and M1592V, showed clearly [ncbi.nlm.nih.gov]

Results: The two most common hyperkalemic periodic paralysis (HyperPP) mutations responsible for episodic attacks of weakness or paralysis, T704M and M1592V, showed clearly [neurology.org]

Hypokalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness typically beginning in childhood or adolescence. [ghr.nlm.nih.gov]

Periodic Paralysis

The affected patients typically present with episodic weakness. [ncbi.nlm.nih.gov]

We report a rare case of episodic limb weakness caused by a tentorial dural arteriovenous fistula (DAVF) draining into the perimesencephalic veins. [ncbi.nlm.nih.gov]

All affected members suffered from episodic weakness; myotonia was also common. [ncbi.nlm.nih.gov]

Hypokalemic Periodic Paralysis

The affected patients typically present with episodic weakness. [ncbi.nlm.nih.gov]

Andersen-Tawil Syndrome (ATS) is a rare potassium channel disorder, characterized by episodic weakness, ventricular arrhythmias and dysmorphic features (short stature, scoliosis [ncbi.nlm.nih.gov]

Abstract Hypokalemic periodic paralysis (HypoKPP) is a dominantly inherited channelopathy of skeletal muscle in which recurrent episodes of severe weakness are often provoked [fasebj.org]

Acute Gastroenteritis

Hypokalemic periodic paralysis is a condition, characterized by episodic weakness of the skeletal muscle. It may be presented as familial or sporadic (secondary). [ncbi.nlm.nih.gov]

Common Cold

Respondents who had experienced a symptomatic VRTI episode were asked specific questions aimed at quantifying health care use and self-care practices. [doi.org]

the presence of the disorder in siblings, frequent hypoglycemia, cardiac enlargement, and muscle weakness. [nejm.org]

[…] little or no fever and usually lasting about 1 week. .. not referring to ‘the flu,' which is usually characterized by high fever, headache, overall body aches, pains, and weakness [doi.org]

Normokalemic Periodic Paralysis

RESULTS: The nine affected members had episodes of muscle weakness reminiscent of both hyperPP and hypoPP. [ncbi.nlm.nih.gov]

Hypokalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness typically beginning in childhood or adolescence. [ghr.nlm.nih.gov]

Chloride channelopathies are not associated with episodic weakness and are discussed in more detail in the articles on myotonic disorders. [emedicine.medscape.com]

Thyrotoxic Periodic Paralysis

We describe a 37-year-old man with a 4-month history of episodic muscular weakness, involving mainly lower-limbs. [ncbi.nlm.nih.gov]

The follow-up period (2–35 months) in patients without KCNJ18 variants showed that episodic weakness did not recur after remission of hyperthyroidism. [bmcneurol.biomedcentral.com]

Thyrotoxic periodic paralysis is a rare and potentially lethal neuromuscular disease that manifests as recurrent episodic muscle weakness associated with hypokalemia and thyrotoxicosis [ncbi.nlm.nih.gov]

Vitamin D Deficiency

We report a four-year-old African boy referred for proximal muscle weakness, fatigability and episodic limb pain. [ncbi.nlm.nih.gov]

Acute Alcohol Intoxication

If the acute episode persists, it may signal a serious complication. [merckmanuals.com]

For example, older people may lose their appetite, feel tired or weak, or vomit. They may not develop a fever. [merckmanuals.com]

Vaginal Candidiasis

An estimated two thirds of women will suffer at least one episode of VVC in their lives and 40-50% may experience multiple episodes (24). [scielo.br]

[…] substantial cause of lower genital infections in women, especially in developing countries and cause significant loss of work hours and significant financial burden on the already weak [scielo.br]

Musculoskeletal Lower Back Pain

Numbness, pins and needles, or weakness in one or both legs. Unsteadiness when you walk How can further episodes of back pain be avoided? [physiofunction.co.uk]

Hypersensitivity

The patient experiences episodes of double vision, weakness, paralysis and various other neurological symptoms, interspersed with periods of remission. [courses.washington.edu]

Essential Hypertension

She was referred to us for episodes of sudden muscle weakness during 8 years prior to admission. On the first day of admission, her blood pressure was 174/104 mmHg. [ncbi.nlm.nih.gov]

Menopause

Some women become giddy, weak, or feel sick during a hot flush. [patient.info]

Some women also develop a 'thumping heart' sensation (palpitations) and feelings of anxiety during the episode. [patient.info]

Insomnia

episodes of muscle weakness (called cataplexy). [merckmanuals.com]

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness with uncontrollable episodes of falling asleep during normal waking hours and sudden, temporary [merckmanuals.com]

Tonsillitis

While some tonsillitis episodes go away on their own, some may require other treatments. [healthline.com]

[…] of tonsillitis or sore throat Tonsillectomy versus no surgery in children 4 –2 0 –1 0 Very low Quality points deducted for weak methods and incomplete reporting of results [ncbi.nlm.nih.gov]

Sweating Nausea Shortness of breath Diagnosis Tests will be done right away to see if you are having an episode of angina or a heart attack. [upstate.edu]

Stomatitis

"One patient heartburn/weakness, one patient diarrhoea in week 5" Zissis 1983 Levamisole versus levamisole placebo versus placebo Unclear due to inconsistency in the text [doi.org]

Weckx 2009 Levamisole versus placebo No statistically significant difference between groups with regard to number of episodes, number of lesions, duration of lesions or pain [doi.org]

Alcohol Abuse

Behaviour change should be encouraged and maladaptive behaviours such as heavy episodic drinking at parties, customary events and weddings should be discouraged. [scielo.org.za]

Zawaira (2009:7) identified risk factors such as weak cultural controls as contributing to alcohol abuse. Cultural teachings could be re-introduced to change behaviours. [scielo.org.za]

Hypoglycemia

Talk with your doctor if you have symptoms of hypoglycemia, even if you only have one episode. How is non-diabetic hypoglycemia diagnosed? [hormone.org]

Blurred vision Headache Trouble performing routine tasks Note: Symptoms can vary from person to person and episode to episode. [visionaware.org]

[…] being: Hungry Shaky Sleepy Anxious Dizzy Confused or nervous Sweaty Irritable Syncope (Passing out, losing consciousness) Some people have trouble speaking and also feel weak [hormone.org]

Acute Respiratory Infection

ARI control programmes ARI control in children • ARI is an episode of acute symptoms & signs resulting from infection of any part of respiratory tract & related structures [slideshare.net]

[…] rates are higher  In severely malnourished: 1) children with pneumonia, fast breathing and chest indrawing may not be evident 2)Impaired or absent response to hypoxia and a weak [slideshare.net]

Sinusitis

Individuals with weak immune systems have a higher risk of developing a fungal or bacterial sinus infection. [houstonent.com]

If you experience more than four sinusitis episodes within a one-year period, it's considered recurrent sinusitis. Often, a bacterial (germ) infection causes it. [houstonent.com]

Atopy

Only a weak, nonsignificant inverse association between the number of fever episodes in the first 12 months of life and skin test sensitisations was found in the control group [erj.ersjournals.com]

# : odds ratio 0.84 (CI 0.74–0.95), p 0.007, for fever episode (adjusted for age, sex, daycare attendance and parental atopy). [erj.ersjournals.com]

Dermatitis

Episodes are most commonly triggered by exposure to cold temperatures. (For more information, choose “Raynaud” as your search term in the Rare Disease Database). [rarediseases.org]

Muscle weakness and impairment may progress to affect other areas of the body, including muscles of the GI tract, within the cardiovascular system (i.e., heart, blood vessels [rarediseases.org]

Cataplexy

Cataplexy refers to sudden, brief and transient episodes of muscle weakness accompanied by both total conscious awareness and bouts of emotion such as laughter, terror, crying [alleydog.com]

Cataplexy is a sudden episode of muscle weakness that occurs while fully aware and conscious. [news-medical.net]

Approximately 70% of people diagnosed with narcolepsy also have episodes of cataplexy. [alleydog.com]

Streptococcal Infection

Initial episodes of ARF as well as recurrences can be prevented by treatment with appropriate antibiotics. [en.wikipedia.org]

A neurological disorder, Sydenham chorea, can occur months after an initial attack, causing jerky involuntary movements, muscle weakness, slurred speech, and personality changes [en.wikipedia.org]

Generalized Tonic-Clonic Seizure

Headache Weakness of 1 side of the body for a few minutes to a few hours following seizure (called Todd paralysis) The doctor will perform a physical exam. [nlm.nih.gov]

Headache Weakness of 1 side of the body for a few minutes to a few hours following seizure (called Todd paralysis) Treatment Treatment for tonic-clonic seizures includes [account.allinahealth.org]

[…] seizure, the person may have: Confusion Drowsiness or sleepiness that lasts for 1 hour or longer (called the post-ictal state) Loss of memory (amnesia) about the seizure episode [nlm.nih.gov]

Oculo-Pharyngo-Distal Myopathy

[…] and Areflexia 444 Case 71 An Elderly Woman with Proximal Weakness 448 Case 72 A Young Woman with Distal Upper Extremity Weakness 454 Case 73A A Young Man with Episodic Weakness [books.google.com]

[…] or Without Ophthalmoparesis Extensor Weakness Prominent Neck Bulbar Weakness Episodic pain,weakness and myoglobinurea Episodic weakness delayed or unrelated to execise stiffness [de.slideshare.net]

[…] a single episode. 25 What is the distribution of weakness? [slideplayer.com]