Episodic Weakness: Causes & Reasons

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Possible Causes for Episodic Weakness

CAPOS Syndrome

[…] of weakness or seizure like episodes. [rarediseases.org]

Patients typically present at an early age with an acute-onset fever-induced episode of ataxia frequently associated with encephalopathy and weakness. [ncbi.nlm.nih.gov]

First episode of ataxia, commonly seen in association with weakness, most often happens between the ages of 6 months and 5 years. [xpertdox.com]

Andersen-Tawil Syndrome

However he never reported any episode of muscular weakness. [japi.org]

Episodic weakness is secondary to abnormalities in sarcolemmal excitability due to dysfunctional ion channels. [scielo.br]

Prolonged Muscle Weakness (EMWX) 1 ● Chromosome Xp22.3; Recessive Clinical Onset age: 0.5 to 8 years Episodes of weakness # Episodes in individual patients: 1 to 10 Duration [neuromuscular.wustl.edu]

Potassium-Aggravated Myotonia

Unlike some other forms of myotonia, potassium-aggravated myotonia is not associated with episodes of muscle weakness. [rarediseases.oscar.ncsu.edu]

These patients do not experience episodic weakness or progressive myopathy. This disease is caused by mutations of the sodium channel SCN4A gene on chromosome 17q. [humpath.com]

weakness does not occur. [n.neurology.org]

Paramyotonia Congenita

Pyridostigmine relieved episodic weakness in a family with paramyotonia congenita resulting from the R1448C mutation in the sodium channel gene. [ncbi.nlm.nih.gov]

The main thing with PC is to determine whether the patient is troubled by episodic weakness, myotonia, or both. [periodicparalysis.org]

One can treat the myotonia with Mexilitine as a first line agent (barring contraindications) and episodic weakness with Daranide or Diamox. [periodicparalysis.org]

Familial Periodic Paralysis

RESULTS: The two most common hyperkalemic periodic paralysis (HyperPP) mutations responsible for episodic attacks of weakness or paralysis, T704M and M1592V, showed clearly [ncbi.nlm.nih.gov]

Results: The two most common hyperkalemic periodic paralysis (HyperPP) mutations responsible for episodic attacks of weakness or paralysis, T704M and M1592V, showed clearly [neurology.org]

Hyperkalemic Periodic Paralysis

Disappearance of episodic weakness during pregnancy and an increase in myotonia after delivery have not been reported in hyperkalemic periodic paralysis (hyperPP). [ncbi.nlm.nih.gov]

Abstract Hyperkalemic periodic paralysis (hyperKPP) and paramyotonia congenita (PC) are genetic muscle disorders sharing the common features of myotonia and episodic weakness [ncbi.nlm.nih.gov]

Because both of these hyperKPP mutations cause episodic muscle weakness, and because patients harboring another mutation ( I693T ) also can have episodic weakness, it is hypothesized [doi.org]

Periodic Paralysis

The affected patients typically present with episodic weakness. [ncbi.nlm.nih.gov]

We report a rare case of episodic limb weakness caused by a tentorial dural arteriovenous fistula (DAVF) draining into the perimesencephalic veins. [ncbi.nlm.nih.gov]

All affected members suffered from episodic weakness; myotonia was also common. [ncbi.nlm.nih.gov]

Hypokalemic Periodic Paralysis

The affected patients typically present with episodic weakness. [ncbi.nlm.nih.gov]

Andersen-Tawil Syndrome (ATS) is a rare potassium channel disorder, characterized by episodic weakness, ventricular arrhythmias and dysmorphic features (short stature, scoliosis [ncbi.nlm.nih.gov]

Abstract Hypokalemic periodic paralysis (HypoKPP) is a dominantly inherited channelopathy of skeletal muscle in which recurrent episodes of severe weakness are often provoked [fasebj.org]

Normokalemic Periodic Paralysis

Hypokalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness typically beginning in childhood or adolescence. [ghr.nlm.nih.gov]

What happens to make me weak during episodes? [hipokalemia.blogspot.com]

Signs and symptoms of this syndrome involve episodic muscle weakness. [medicinenet.com]

Thyrotoxic Periodic Paralysis

We describe a 37-year-old man with a 4-month history of episodic muscular weakness, involving mainly lower-limbs. [ncbi.nlm.nih.gov]

The correction of the hyperthyroid function with metimazol and propranolol prevented further episodes of muscle weakness. [actamedicaportuguesa.com]

Thyrotoxic periodic paralysis is a rare and potentially lethal neuromuscular disease that manifests as recurrent episodic muscle weakness associated with hypokalemia and thyrotoxicosis [ncbi.nlm.nih.gov]

Non-Dystrophic Myotonia

If episodic weakness is absent, SCM may closely mimic myotonia congenita. [now.aapmr.org]

Non-dystrophic myotonia describes a group of myotonic disorders associated with or without episodic weakness. [now.aapmr.org]

The periodic paralyses are a group of disorders associated with prominent features of episodic flaccid weakness. [now.aapmr.org]

Myotonia permanens

If episodic weakness is absent, SCM may closely mimic myotonia congenita. [now.aapmr.org]

All options are aimed primarily at treating either episodic weakness or myotonia. [pn.bmj.com]

[…] channel myotonia—notable for the absence of episodic weakness but may have cold sensitivity. [medscape.com]

Acetazolamide-Responsive Myotonia

If episodic weakness is absent, SCM may closely mimic myotonia congenita. [now.aapmr.org]

[…] channel myotonia—notable for the absence of episodic weakness but may have cold sensitivity. [medscape.com]

Sometimes people with Becker myotonia congenita experience temporary weakness after an episode of myotonia. [unlockndm.eu]

Myotonic Dystrophy Type 2

The clinical picture is dominated by the presence of myotonia and other minor muscular complaints as mild episodic weakness and muscle hypertrophy. [ncbi.nlm.nih.gov]

Myotonic Dystrophy Type 1

The clinical picture is dominated by the presence of myotonia and other minor muscular complaints as mild episodic weakness and muscle hypertrophy. [ncbi.nlm.nih.gov]

Cataplexy

Cataplexy refers to sudden, brief and transient episodes of muscle weakness accompanied by both total conscious awareness and bouts of emotion such as laughter, terror, crying [alleydog.com]

Cataplexy is a sudden episode of muscle weakness that occurs while fully aware and conscious. [news-medical.net]

Approximately 70% of people diagnosed with narcolepsy also have episodes of cataplexy. [alleydog.com]

Individuals can present with intermittent acute episodes of rhabdomyolysis. Dark urine due to myoglobinuria and profound lower-extremity weakness can develop. [ncbi.nlm.nih.gov]

Profound episodic muscle weakness Ataxia Disorientation Coma Intermittent dysphagia Cardiac arrhythmias Developmental delay Intellectual disability Regression of motor and [ncbi.nlm.nih.gov]

The first episode of myoglobinuria has been known to occur as early as age five months. [ncbi.nlm.nih.gov]

Myotonia fluctuans

Episodic weakness is rare. [orpha.net]

There were no episodes of weakness, and the myotonia was exacerbated by potassium loading. [jamanetwork.com]

Unlike some other forms of myotonia, potassium-aggravated myotonia is not associated with episodes of muscle weakness. [medlineplus.gov]

Myopathy

[…] of weakness in the arms and legs polymyositis, inclusion body myositis, and related myopathies: inflammatory myopathies of skeletal muscle neuromyotonia: characterized by [ninds.nih.gov]

[…] of weakness in the arms and legs Myositis Ossificans characterized by bone growing in muscle tissue Stiff-Man Syndrome characterized by episodes of rigidity and reflex spasms [smartdraw.com]

Previous episodes of severe weakness (eg, postexercise, after exposure to cold [possibly one of periodic paralyses]; post high-carbohydrate meals [familial hypokalemic periodic [emedicine.medscape.com]

Familial Infantile Myasthenia

weakness and apnea during the first two years of life, and (5) improvement with age. [researchers.dellmed.utexas.edu]

The condition is characterized by (1) absence of myasthenia in the mother, (2) occurrence of a similar disorder among siblings, (3) respiratory depression at birth, (4) episodic [researchers.dellmed.utexas.edu]

Oculo-Pharyngo-Distal Myopathy

[…] or Without Ophthalmoparesis Extensor Weakness Prominent Neck Bulbar Weakness Episodic pain,weakness and myoglobinurea Episodic weakness delayed or unrelated to execise stiffness [de.slideshare.net]

[…] a single episode. 25 What is the distribution of weakness? [slideplayer.com]

[…] and Areflexia 444 Case 71 An Elderly Woman with Proximal Weakness 448 Case 72 A Young Woman with Distal Upper Extremity Weakness 454 Case 73A A Young Man with Episodic Weakness [books.google.com]

Lissencephaly Type 8

[…] of weak muscle tone (drop attacks); rapid, uncontrolled muscle jerks (myoclonic seizures); and episodes of muscle rigidity, convulsions, and loss of consciousness (tonic-clonic [medlineplus.gov]

[…] life, most children with ILS develop a variety of seizure types, including persisting infantile spasms, short periods of loss of consciousness (absence seizures); sudden episodes [medlineplus.gov]

Alternating Hemiplegia of Childhood

From Wikidata Jump to navigation Jump to search hemiplegia characterized by recurrent episodes of temporary weakness or complete paralysis on one or both sides of the body [wikidata.org]

After an episode, the weakness improves, but will recur during the next episode. [gosh.nhs.uk]

We are reporting a child with history of recurrent episodes of weakness involving either side of the body with developmental delay. [content.iospress.com]

Facial Diplegia with Paresthesias

The paper reports a case of a 14-year-old girl who developed paresthesias in the distal limbs and subsequently bifacial weakness, dysphonia and dysphagia. [medicoebambino.com]

She had had a preceding episode of upper tract respiratory infection. Neurological examination showed severe facial diplegia. Limb muscle power was preserved. [medicoebambino.com]

Charcot-Marie-Tooth Disease Type 2D

Slight compression of peripheral nerves and repeated local exercise leads to episodes of weakness with decreased perception to touch and pain. [emedicine.medscape.com]

Individuals experience episodic brachial plexus neuropathy with weakness, atrophy, and sensory disturbances, preceded almost always by severe pain in the affected arm. [emedicine.medscape.com]

Jacob et al in 1961 described in 7 patients of 2 unrelated families 14 similar episodes of recurrent brachial neuritis with incapacitating pain, weakness, wasting, depression [emedicine.medscape.com]

Classic Migraine

Case presentation We describe the case of a young woman (33 year old) who suffered from the age of 8 years of episodic weakness of the limbs, associated to other subjective [thejournalofheadacheandpain.biomedcentral.com]

He had three episodes of transient left-sided weakness with facial deviation occurring over the preceding 2 months prior to referral. [neurologyindia.com]

These episodes can include fever, prolonged weakness, seizures, and coma. [icdlist.com]

Myopathy with Abnormal Lipid Metabolism

Even those patients with hypokalemic periodic paralysis who have never experienced episodic weakness, a common scenario in affected females, invariably will develop a proximal [clinicalgate.com]

Acuteness of symptoms: Weakness over hours suggests a toxic cause or episodic paralysis. Weakness developing over days - consider dermatomyositis or rhabdomyolysis. [patient.info]

These myopathies can cause progressive muscle weakness, fatigue, episodes of pain and cramps after exercise, and/or extensive death and breakdown of muscle tissue. [rheumatology.org]

Mitochondrial Myopathy

The symptoms of mitochondrial myopathies include muscle weakness or exercise intolerance, heart failure or rhythm disturbances, dementia, movement disorders, stroke-like episodes [ninds.nih.gov]

[…] mitochondrial myopathies include Kearns-Sayre syndrome, myoclonus epilepsy with ragged-red fibers, and mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes [ninds.nih.gov]

The prognosis for these disorders ranges in severity from progressive weakness to death. [ninds.nih.gov]

Narcolepsy-Cataplexy Syndrome

One condition causes unexpected episodes of sleep: the other condition causes unexpected episodes of muscle weakness. [labovick.com]

Polysomnography Multiple sleep latency testing Doctors suspect narcolepsy when people with excessive daytime sleepiness have had episodes of muscle weakness. [merckmanuals.com]

Both authors noted the association between sleep episodes and attacks of muscle weakness triggered by emotion. [ispub.com]

Ovarioleukodystrophy

Exploring the utility of whole-exome sequencing as a diagnostic tool in a child with atypical episodic muscle weakness. [ncbi.nlm.nih.gov]