Episodic Weakness: Causes & Reasons

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Possible Causes for Episodic Weakness

CAPOS Syndrome

[…] of weakness or seizure like episodes. [rarediseases.org]

Patients typically present at an early age with an acute-onset fever-induced episode of ataxia frequently associated with encephalopathy and weakness. [ncbi.nlm.nih.gov]

First episode of ataxia, commonly seen in association with weakness, most often happens between the ages of 6 months and 5 years. [xpertdox.com]

Cardiodysrhythmic Potassium-Sensitive Periodic Paralysis

However he never reported any episode of muscular weakness. [japi.org]

Episodic weakness is secondary to abnormalities in sarcolemmal excitability due to dysfunctional ion channels. [scielo.br]

Prolonged Muscle Weakness (EMWX) 1 ● Chromosome Xp22.3; Recessive Clinical Onset age: 0.5 to 8 years Episodes of weakness # Episodes in individual patients: 1 to 10 Duration [neuromuscular.wustl.edu]

Paramyotonia Congenita

Pyridostigmine relieved episodic weakness in a family with paramyotonia congenita resulting from the R1448C mutation in the sodium channel gene. [ncbi.nlm.nih.gov]

The main thing with PC is to determine whether the patient is troubled by episodic weakness, myotonia, or both. [periodicparalysis.org]

One can treat the myotonia with Mexilitine as a first line agent (barring contraindications) and episodic weakness with Daranide or Diamox. [periodicparalysis.org]

Periodic Paralysis

The affected patients typically present with episodic weakness. [ncbi.nlm.nih.gov]

We report a rare case of episodic limb weakness caused by a tentorial dural arteriovenous fistula (DAVF) draining into the perimesencephalic veins. [ncbi.nlm.nih.gov]

All affected members suffered from episodic weakness; myotonia was also common. [ncbi.nlm.nih.gov]

Hyperkalemic Periodic Paralysis

Disappearance of episodic weakness during pregnancy and an increase in myotonia after delivery have not been reported in hyperkalemic periodic paralysis (hyperPP). [ncbi.nlm.nih.gov]

Abstract Hyperkalemic periodic paralysis (hyperKPP) and paramyotonia congenita (PC) are genetic muscle disorders sharing the common features of myotonia and episodic weakness [ncbi.nlm.nih.gov]

Because both of these hyperKPP mutations cause episodic muscle weakness, and because patients harboring another mutation ( I693T ) also can have episodic weakness, it is hypothesized [doi.org]

Familial Periodic Paralysis

RESULTS: The two most common hyperkalemic periodic paralysis (HyperPP) mutations responsible for episodic attacks of weakness or paralysis, T704M and M1592V, showed clearly [ncbi.nlm.nih.gov]

Results: The two most common hyperkalemic periodic paralysis (HyperPP) mutations responsible for episodic attacks of weakness or paralysis, T704M and M1592V, showed clearly [neurology.org]

Hypokalemic Periodic Paralysis

The affected patients typically present with episodic weakness. [ncbi.nlm.nih.gov]

Andersen-Tawil Syndrome (ATS) is a rare potassium channel disorder, characterized by episodic weakness, ventricular arrhythmias and dysmorphic features (short stature, scoliosis [ncbi.nlm.nih.gov]

Abstract Hypokalemic periodic paralysis (HypoKPP) is a dominantly inherited channelopathy of skeletal muscle in which recurrent episodes of severe weakness are often provoked [fasebj.org]

Normokalemic Periodic Paralysis

Chloride channelopathies are not associated with episodic weakness and are discussed in more detail in the articles on myotonic disorders. [emedicine.medscape.com]

Hypokalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness typically beginning in childhood or adolescence. [ghr.nlm.nih.gov]

What happens to make me weak during episodes? [hipokalemia.blogspot.com]

Thyrotoxic Periodic Paralysis

The follow-up period (2–35 months) in patients without KCNJ18 variants showed that episodic weakness did not recur after remission of hyperthyroidism. [bmcneurol.biomedcentral.com]

We describe a 37-year-old man with a 4-month history of episodic muscular weakness, involving mainly lower-limbs. [ncbi.nlm.nih.gov]

Oculo-Pharyngo-Distal Myopathy

[…] or Without Ophthalmoparesis Extensor Weakness Prominent Neck Bulbar Weakness Episodic pain,weakness and myoglobinurea Episodic weakness delayed or unrelated to execise stiffness [de.slideshare.net]

[…] a single episode. 25 What is the distribution of weakness? [slideplayer.com]

[…] and Areflexia 444 Case 71 An Elderly Woman with Proximal Weakness 448 Case 72 A Young Woman with Distal Upper Extremity Weakness 454 Case 73A A Young Man with Episodic Weakness [books.google.com]

Myotonic Dystrophy Type 1

The clinical picture is dominated by the presence of myotonia and other minor muscular complaints as mild episodic weakness and muscle hypertrophy. [ncbi.nlm.nih.gov]

Myotonic Dystrophy Type 2

The clinical picture is dominated by the presence of myotonia and other minor muscular complaints as mild episodic weakness and muscle hypertrophy. [ncbi.nlm.nih.gov]

Potassium-Aggravated Myotonia

Unlike some other forms of myotonia, potassium-aggravated myotonia is not associated with episodes of muscle weakness. [rarediseases.oscar.ncsu.edu]

These patients do not experience episodic weakness or progressive myopathy. This disease is caused by mutations of the sodium channel SCN4A gene on chromosome 17q. [humpath.com]

weakness does not occur. [n.neurology.org]

Cataplexy

Cataplexy refers to sudden, brief and transient episodes of muscle weakness accompanied by both total conscious awareness and bouts of emotion such as laughter, terror, crying [alleydog.com]

Cataplexy is a sudden episode of muscle weakness that occurs while fully aware and conscious. [news-medical.net]

Approximately 70% of people diagnosed with narcolepsy also have episodes of cataplexy. [alleydog.com]

Non-Dystrophic Myotonia

If episodic weakness is absent, SCM may closely mimic myotonia congenita. [now.aapmr.org]

Non-dystrophic myotonia describes a group of myotonic disorders associated with or without episodic weakness. [now.aapmr.org]

The periodic paralyses are a group of disorders associated with prominent features of episodic flaccid weakness. [now.aapmr.org]

Familial Infantile Myasthenia

weakness and apnea during the first two years of life, and (5) improvement with age. [researchers.dellmed.utexas.edu]

The condition is characterized by (1) absence of myasthenia in the mother, (2) occurrence of a similar disorder among siblings, (3) respiratory depression at birth, (4) episodic [researchers.dellmed.utexas.edu]

Charcot-Marie-Tooth Disease Type 2D

Slight compression of peripheral nerves and repeated local exercise leads to episodes of weakness with decreased perception to touch and pain. [emedicine.medscape.com]

Individuals experience episodic brachial plexus neuropathy with weakness, atrophy, and sensory disturbances, preceded almost always by severe pain in the affected arm. [emedicine.medscape.com]

Jacob et al in 1961 described in 7 patients of 2 unrelated families 14 similar episodes of recurrent brachial neuritis with incapacitating pain, weakness, wasting, depression [emedicine.medscape.com]

Myopathy

[…] of weakness in the arms and legs polymyositis, inclusion body myositis, and related myopathies: inflammatory myopathies of skeletal muscle neuromyotonia: characterized by [ninds.nih.gov]

[…] of weakness in the arms and legs Myositis Ossificans characterized by bone growing in muscle tissue Stiff-Man Syndrome characterized by episodes of rigidity and reflex spasms [smartdraw.com]

Previous episodes of severe weakness (eg, postexercise, after exposure to cold [possibly one of periodic paralyses]; post high-carbohydrate meals [familial hypokalemic periodic [emedicine.medscape.com]

ABri Amyloidosis

Young Woman with Difficulty Swallowing 433 Case 69 A Young Woman with Intermittent Weakness and a Positive Family History of Similar Problems 436 Case 70 A Woman with Muscle Weakness [books.google.de]

Alternating Hemiplegia of Childhood

From Wikidata Jump to navigation Jump to search hemiplegia characterized by recurrent episodes of temporary weakness or complete paralysis on one or both sides of the body [wikidata.org]

After an episode, the weakness improves, but will recur during the next episode. [gosh.nhs.uk]

We are reporting a child with history of recurrent episodes of weakness involving either side of the body with developmental delay. [content.iospress.com]

Classic Migraine

Case presentation We describe the case of a young woman (33 year old) who suffered from the age of 8 years of episodic weakness of the limbs, associated to other subjective [thejournalofheadacheandpain.biomedcentral.com]

He had three episodes of transient left-sided weakness with facial deviation occurring over the preceding 2 months prior to referral. [neurologyindia.com]

These episodes can include fever, prolonged weakness, seizures, and coma. [icdlist.com]

Myopathy with Abnormal Lipid Metabolism

Even those patients with hypokalemic periodic paralysis who have never experienced episodic weakness, a common scenario in affected females, invariably will develop a proximal [clinicalgate.com]

Acuteness of symptoms: Weakness over hours suggests a toxic cause or episodic paralysis. Weakness developing over days - consider dermatomyositis or rhabdomyolysis. [patient.info]

These myopathies can cause progressive muscle weakness, fatigue, episodes of pain and cramps after exercise, and/or extensive death and breakdown of muscle tissue. [rheumatology.org]

Acquired Amyloid Myopathy

However, these patients most often have normal potassium values if tested between episodes of weakness. [clinicalgate.com]

Keys to Diagnosis: Muscle biopsy and measurement of muscle enzyme levels are usually required to establish the diagnosis in a patient with episodic or exercise-induced weakness [rheumaknowledgy.com]

Tubular Aggregate Myopathy

Keywords Tubular aggregates STIM1 gene Episodic muscle weakness References 1. Engel WK, Bishop DW, Cunningham GG. [link.springer.com]

Chapter First Online: 06 October 2017 Abstract This form of congenital myopathy is characterized by slowly progressive weakness without atrophy, myalgia, cramps, or episodic [link.springer.com]

Chapter First Online: 27 June 2014 Abstract This form of congenital myopathy is characterized by slowly progressive weakness without atrophy, myalgia, cramps, or episodic [link.springer.com]

Charcot-Marie-Tooth Disease

The episodic weakness has been responsive to acetazolamide therapy for a few decades. [ncbi.nlm.nih.gov]

Episodic weakness and numbness Conduction Blocks Dejerine-Sottas syndrome (DSS) or hereditary motor and sensory neuropathy (HMSN) 3 P 0 ; AR PMP-22; AD 8q23; AD 2 y Severe [emedicine.medscape.com]

[…] without previous signs of lower extremity weakness or foot deformities; the patient, as well as his asymptomatic mother, exhibited a novel GJB1 mutation (p.Met1Ile). [ncbi.nlm.nih.gov]

Autosomal Dominant Myoglobinuria

G U: acute renal failure Muscle: episodic myalgia mild muscle weakness enlarged calf muscles Misc: precipitated by fever, viral illness, prolonged exercise, or alcohol use [malacards.org]

Autosomal dominant disorder with a high degree of penetrance, which manifests as episodic weakness usually during the first decade. [sites.google.com]

Narcolepsy-Cataplexy Syndrome

One condition causes unexpected episodes of sleep: the other condition causes unexpected episodes of muscle weakness. [labovick.com]

Polysomnography Multiple sleep latency testing Doctors suspect narcolepsy when people with excessive daytime sleepiness have had episodes of muscle weakness. [merckmanuals.com]

Both authors noted the association between sleep episodes and attacks of muscle weakness triggered by emotion. [ispub.com]

Conn Syndrome

Symptoms and signs include episodic weakness, elevated blood pressure, and hypokalemia. [msdmanuals.com]

Symptoms and signs include episodic weakness, elevated BP, and hypokalemia. Diagnosis includes measurement of plasma aldosterone levels and plasma renin activity. [msdmanuals.com]

Symptoms and Signs of Primary Aldosteronism Hypernatremia, hypervolemia, and a hypokalemic alkalosis may occur, causing episodic weakness, paresthesias, transient paralysis [msdmanuals.com]

Phosphoglycerate Kinase 1 Deficiency

Some patients may have a purely myopathic syndrome with progressive proximal muscle weakness and episodes of myoglobinuria, exercise intolerance, and easy fatigue. [mda.org.au]

Myopathy is a common finding and is characterized by exercise-intolerance, muscle weakness, cramping, myalgia and episodes of myoglobinuria. [orpha.net]

[…] and episodes of myoglobinuria, exercise intolerance and easy fatigue. [patient.info]

Mononeuritis

These more cataclysmic episodes of numbness or weakness necessitate a thorough diagnostic evaluation, both by nerve-conduction tests, and often by biopsy of nerve and/or muscles [hopkinssjogrens.org]