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72 Possible Causes for Epistaxis, Progressive Polyneuropathy, Pruritus

  • Multiple Myeloma

    Patients with a high tumor volume may present with epistaxis.[symptoma.com] Her pruritus resolved, but the lesions persisted. Footnotes Competing interests: None declared. This article has been peer reviewed.[cmaj.ca] […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org]

  • Waldenstrom Macroglobulinemia

    Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[emedicine.medscape.com] A 71-year-old woman presented with malaise, skin bruising, epistaxis, and gingival bleeding of recent and prompt onset. There was no adenopathy.[ncbi.nlm.nih.gov] Clinically, patients may present with fatigue, weight loss, peripheral neuropathy or symptoms of hyperviscosity, including headache, blurred vision or epistaxis.[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    Generalised pruritus Generalised skin itching ( pruritus ) may occur due to the build up of poorly metabolised substances that stimulate nerve endings in the skin.[dermnetnz.org] Patients may present with jaundice, pruritus, abnormal laboratory findings (eg, thrombocytopenia, hypoalbuminemia, coagulopathy), or complications of portal hypertension,[clevelandclinicmeded.com]

  • Diabetes Mellitus

    […] undetermined), 21.1% were sight-threatening bleeding events in the eye, 17.2% were intracranial bleeding events, and 20.4% were bleeding events in other sites (mainly hematuria and epistaxis[nejm.org] […] outweighed by the benefits of reducing cardiovascular risk. [ 8 ] Presentation Patients with all types of diabetes may present with polyuria, polydipsia, lethargy, boils, pruritus[patient.info] Symptoms develop 30 min to 2 h after injection and include urticaria, angioedema, pruritus, bronchospasm, and anaphylaxis.[msdmanuals.com]

  • Vasculitis

    Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[neuromuscular.wustl.edu] Upper respiratory tract lesions include recurrent rhinitis, sinusitis, epistaxis and serous otitis media.[symptoma.com] The lesions may be asymptomatic or associated with burning, pruritus, or pain.[clinicaladvisor.com]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] Nasopharyngeal amyloidosis: an unusual cause for epistaxis . The Journal of Laryngology & Otology, Vol. 124, Issue. 02, p. 209.[journals.cambridge.org] This case demonstrates an unusual presentation of primary systemic amyloidosis consisting of arthritis and intense debilitating pruritus without primary skin lesions for a[ncbi.nlm.nih.gov]

  • Microscopic Polyangiitis

    We present the case of a 67-year-old female patient with microscopic polyangiitis presented with polyneuropathy of lower extremities and rapidly progressive glomerulonephritis[ncbi.nlm.nih.gov] […] with polyangiitis (GPA) by absence of granulomatous inflammation Clinical Presentation Constitutional – weight loss, fever, myalgias Otorhinolaryngological – oral ulcers, epistaxis[arupconsult.com] Cutaneous lesions of LCV are often asymptomatic, but may be associated with pruritus or pain.[emedicine.medscape.com]

  • Familial Progressive Polyneuropathy

    Abstract The purpose of this study was to evaluate the clinical and pathological features in patients with progressive-type familial amyloidotic polyneuropathy (FAP) using[ncbi.nlm.nih.gov] […] vessels Systemic features Renal (80%) Glomerulonephritis Active urinary sediment Pathology: Focal segmental necrotizing glomerulonephritis Pulmonary Upper airway: Sinusitis, Epistaxis[neuromuscular.wustl.edu] Pruritus. Dry skin. Pale, cold feet. Worsening of symptoms at night. Examination There may be features on general examination which point to a specific disease.[patient.info]

  • Myeloma-associated Amyloidosis

    The peripheral neuropathy of MGUS is classically bilateral, peripheral and sensory with electrophysiologic studies showing a demyelinating pattern; and in patients with progressive[hematology.org] Affected individuals may rarely experience repeated nosebleeds (epistaxis).[rarediseases.org] Milder cases may get some improvement with potent topical steroids, and pruritus may be improved with topical cooling agents such as 1-2% menthol in aqueous cream, sedating[pcds.org.uk]

  • Erythema Chronicum Migrans

    Peripheral polyneuropathy In Europe and Asia: acrodermatitis chronica atrophicans (ACA, also called Herxheimer's disease ) Chronically progressive dermatological disease due[amboss.com] Recurrent epistaxis is the most common presenting manifestation of the syndrome, affecting approximately 85% to 90% of patients.[clevelandclinicmeded.com] Lesions Excoriation Papule / erythematous Plaque / erythematous Pathophysiology infectious diseases / bacterial infections / Borelliosis / erythema chronicum migrans Symptoms Pruritus[dermquest.com]

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