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760 Possible Causes for Epistaxis, Splenomegaly

  • Upper Respiratory Infection

    Epistaxis may also occur. Lower respiratory tract disease and sepsis represent serious complications, especially in patients with immunocompromise.[emedicine.medscape.com] Approximately half of EBV mononucleosis cases involve generalized adenopathy or splenomegaly. An enlarged liver may also be palpable.[emedicine.medscape.com]

  • Malignant Neoplasm

    Rhinorrhea and epistaxis may also be present.[emedicine.medscape.com] Both low- and high-grade adenocarcinoma can cause obstructive symptoms, rhinorrhea, or epistaxis.[emedicine.medscape.com] Its presentation is similar to other sinonasal malignancies (SNM); nasal obstruction and epistaxis being the most common presenting symptoms.[emedicine.medscape.com]

  • Hypersplenism

    Prior to splenectomy the patient continued to have a marked thrombocytopenia which resulted in recurrent bouts of epistaxis; splenectomy together with tuberculostatic therapy[ncbi.nlm.nih.gov] While 38 patients displayed splenomegaly, 121 showed normal spleen volumes at 6 months after LDLT (LDLT).[ncbi.nlm.nih.gov] In addition, symptoms such as epistaxis and gingival bleeding were ameliorated or even eliminated, and the quality of life was improved.[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    Epistaxis, gastrointestinal bleeding, and to the formation of hematomas are also common. CLL patients also tend to autoimmune reactions.[symptoma.com] After 3 years, he presented a CLL progression with worsening lymphocytosis, anemia, thrombocytopenia, increased splenomegaly, and lymphadenopathies.[ncbi.nlm.nih.gov] ; anterior nasal bleeding; pustulous non-itching lesions at the cervical region and posterior thorax; enlarged bilateral axillary lymph nodes; hepatomegaly; and moderate splenomegaly[ncbi.nlm.nih.gov]

  • Leukemia

    Bleeding is usually manifested by petechiae, easy bruising, epistaxis, bleeding gums, or menstrual irregularity. Hematuria and GI bleeding are uncommon.[merckmanuals.com] […] fatigue Pain in bone Fever accompanied by chills Excessive sweating especially during night hours Easy prone to infections Bleeding or bruising very easily Hepatomegaly Splenomegaly[symptoma.com] 90% Severe in 90% Mild in about 50% Mild in 80% Platelets Low in 80% Low in 90% Low in 20 to 30% High in 60% Low in 10% Lymphadenopathy Common Occasional Common Infrequent Splenomegaly[merckmanuals.com]

  • Myelodysplasia

    Fewer than 20% of patients present with symptoms of isolated thrombocytopenia such as minor bleeding (eg, mucosal bleeding, petechiae, easy bruising, epistaxis) or major bleeding[mdedge.com] Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] When the levels of platelets fall, petechiae, ecchymoses, epistaxis and gum bleeding may result.[symptoma.com]

  • Polycythemia Vera

    Bleeding is seen in approximately 1% of patients, epistaxis, gum bleeding, ecchymoses, and gastrointestinal (GI) bleeding.[symptoma.com] […] in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] 180 g per L) in white men, 16 g per dL (160 g per L) in blacks and women) Plethora Pruritus after bathing Splenomegaly Weight loss Weakness Sweating Less Common Bruising/epistaxis[aafp.org]

  • Immune Thrombocytopenic Purpura

    An 11-year-old boy presented with epistaxis, petechial hemorrhages, easy bruising, and purpuric rash.[ncbi.nlm.nih.gov] Clinical examination revealed mucosal hemorrhages and splenomegaly.[ncbi.nlm.nih.gov] Clinical manifestations may range from spontaneous formation of purpura and petechiae, especially on the extremities, to epistaxis, bleeding at the gums or menorrhagia, any[ncbi.nlm.nih.gov]

  • Waldenstrom Macroglobulinemia

    A 71-year-old woman presented with malaise, skin bruising, epistaxis, and gingival bleeding of recent and prompt onset. There was no adenopathy.[ncbi.nlm.nih.gov] Manifestations of macroglobulinemic lymphoma include lymphadenopathy, splenomegaly and bone marrow involvement.[ncbi.nlm.nih.gov] He unfortunately continued to have bouts of epistaxis and his thrombocytopenia worsened.[pubs.sciepub.com]

  • Psittacosis

    Diagnosis can be suspected in case of respiratory infection associated with splenomegaly and/or epistaxis.[en.wikipedia.org] Debutul este adesea insidios, cu febra, uneori de aspect difazie, cu simptome discrete (epistaxis, mialgii, fenomene catarale respiratorii, tuse uscata, cefalee, dureri toracice[esanatos.com] Diagnosis can be suspected in case of respiratory infection associated with splenomegaly and/or epistaxis.[en.wikipedia.org]

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