morphological abnormalities, haemolysis, and hypoglycosylation of red-blood-cell membrane proteins and lipids.
[cureus.com]
abnormalities in the erythroblasts.
[jcp.bmj.com]
abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis.
[genecards.org]
Congenital dyserythropoietic anemias (CDAs) are rare hereditary blood disorders characterized by ineffective erythropoiesis, hemolysis, and erythroblast morphologic abnormalities
[ncbi.nlm.nih.gov]
Abstract Congenital dyserythropoietic anemia type II (CDAII) is an autosomal recessive disease characterized by ineffective erythropoiesis, hemolysis, erythroblast morphological
[ncbi.nlm.nih.gov]
morphological abnormalities. alpha-Interferon has been reported to be effective in type I CDA, but efficacy in other types of CDA is uncertain.
[ncbi.nlm.nih.gov]
morphological abnormalities, haemolysis, and hypoglycosylation of red-blood-cell membrane proteins and lipids.
[cureus.com]
These cases showed increased levels of fetal hemoglobin, a very large number of nucleated red blood cells in peripheral blood and bone marrow erythroblast morphologic abnormalities
[bloodgenetics.com]
Discussion CDAs are a group of hereditary refractory anemias characterized by ineffective erythropoiesis, typical morphological abnormalities of erythroblasts, low or no reticulocyte
[annsaudimed.net]
abnormalities of erythroblasts in the bone marrow.
[omicsonline.org]
abnormalities of the erythroblasts in the bone marrow.
[scholars.northwestern.edu]
Discussion CDAs are a group of hereditary refractory anemias characterized by ineffective erythropoiesis, typical morphological abnormalities of erythroblasts, low or no reticulocyte
[annsaudimed.net]
Each of the three originally described forms, designated CDA types I to III, is defined by the presence of distinctive morphologic (including ultrastructural) abnormalities
[journals.lww.com]
abnormalities in the erythroblasts.
[jcp.bmj.com]
abnormalities of the erythroblasts in the bone marrow.
[link.springer.com]
Discussion CDAs are a group of hereditary refractory anemias characterized by ineffective erythropoiesis, typical morphological abnormalities of erythroblasts, low or no reticulocyte
[annsaudimed.net]
[…] myelodysplasia; acquired clonal cytogenetic abnormality in hematopietic cells; increased blast count (>5%) [ 3 ].
[intechopen.com]
Congenital dyserythropoietic anemias (CDA) are a group of hereditary refractory anemias characterized by ineffective erythropoiesis, typical morphological abnormalities of
[annsaudimed.net]
Mixed cellular population of blasts and red cell precursors, some showing morphologic abnormalities. Plasma cell at upper right.
[meds.com]
We conclude that acute erythroblastic leukemia, when defined by morphologic criteria, consists of two distinctive subgroups: one group tends to be older, has complex cytogenetic
[ncbi.nlm.nih.gov]
[…] of abnormal erythroblasts; 2) erythroleukemia, in which an increase in erythroblasts and in myeloblasts is seen; 3) myeloblastic leukemia.
[userlogic.com]
Mixed cellular population of blasts and red cell precursors, some showing morphologic abnormalities. Plasma cell at upper right.
[meds.com]
morphological abnormalities, the early erythroblasts can contain large quantities of haemoglobin F. 14 Both of our cases had splenomegaly; in case 1, a liver biopsy showed
[jcp.bmj.com]
More than 50%* of the nucleated marrow cells are abnormal nucleated red blood cells.
[med-ed.virginia.edu]
Striking morphologic abnormalities of erythroblasts, reviewed by Wickramasinghe and Wood (2005), include the 'Swiss-cheese' abnormality of erythroblasts on electron microscopy.Four
[mendelian.co]
It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis (Tamary et al., 2005).
[mendelian.co]
PAS- Erythroblasts 33. Morphological abnormalities in MDSs 34.
[slideshare.net]
Striking morphologic abnormalities of erythroblasts, reviewed by Wickramasinghe and Wood (2005), include the 'Swiss-cheese' abnormality of erythroblasts on electron microscopy.Four
[mendelian.co]
It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis ( Tamary et al., 2005 ).
[mendelian.co]
In these cases, the erythropoiesis is abnormal morphologically and functionally. Erythroblastopenia as dyserythropoiesis may have a hereditary or acquired origin.
[dx.doi.org]
In contrast to pure red cell aplasia, the bone marrow is rich in erythroblasts in patients with dyserythropoiesis.
[dx.doi.org]
abnormalities of erythroblasts in the bone marrow.
[kegg.jp]
Congenital dyserythropoietic anemias (CDAs) Congenital dyserythropoietic anemias (CDAs) are rare hereditary disorders characterized by ineffective erythropoiesis and by distinct morphological
[kegg.jp]
More than 50%* of the nucleated marrow cells are abnormal nucleated red blood cells.
[med-ed.virginia.edu]
A recent, detailed morphologic analysis of the abnormal promyelocytes in APL has led to a better appreciation of the cytologic variability of the leukemic cells in this disorder
[doi.org]
Acute Erythroblastic Leukemia - FAB M6 Maturation: M6 or erythroleukemia is rare and difficult to diagnose.
[med-ed.virginia.edu]
More than 50%* of the nucleated marrow cells are abnormal nucleated red blood cells.
[med-ed.virginia.edu]
A recent, detailed morphologic analysis of the abnormal promyelocytes in APL has led to a better appreciation of the cytologic variability of the leukemic cells in this disorder
[doi.org]
Acute Erythroblastic Leukemia - FAB M6 Maturation: M6 or erythroleukemia is rare and difficult to diagnose.
[med-ed.virginia.edu]
Similar morphologic abnormalities can be seen in the other myeloid elements, e.g., large or giant metamyelocytes and other granulocytic precursors.
[ncbi.nlm.nih.gov]
These abnormalities are most evident in the erythroid precursors with large megaloblastic erythroblasts present in increased numbers throughout the marrow.
[ncbi.nlm.nih.gov]
The bone marrow is hypercellular, showing evidence of abnormal proliferation and maturation of multiple myeloid cell lines.
[ncbi.nlm.nih.gov]
The erythroblast is abnormal with bizarre morphologic features. Giant multilobular or multinucleated forms are common.
[intechopen.com]
The cytochemistry of erythroblasts are normally PAS negative but in AML-M6, erythroblasts especially pronormoblast demonstrates coarse positivity of PAS.
[intechopen.com]
The CDAs comprise a group of heterogenous disorders characterized by ineffective erythropoiesis as the predominant mechanism of anemia and distinct morphologic abnormalities
[bloodjournal.org]
[…] of the majority of erythroblasts in the bone marrow. 11 The CDAs have been classified into 3 types based on morphologic and serologic findings, 12 but there is clearly heterogeneity
[bloodjournal.org]
More than 50%* of the nucleated marrow cells are abnormal nucleated red blood cells.
[med-ed.virginia.edu]
Acute Erythroblastic Leukemia - FAB M6 Maturation: M6 or erythroleukemia is rare and difficult to diagnose.
[med-ed.virginia.edu]
Morphology: The leukemic red cells are frequently bizarre with extreme dysplastic features including: giant forms, multinucleation, cytoplasmic vacuolization, cytoplasmic
[med-ed.virginia.edu]
More than 50%* of the nucleated marrow cells are abnormal nucleated red blood cells.
[med-ed.virginia.edu]
Normal erythroblasts and megakaryocytes. AML with maturation (FAB classification M2) is the most common morphologic type correlating with t(8; 21).
[northshore.org]
Acute Erythroblastic Leukemia - FAB M6 Maturation: M6 or erythroleukemia is rare and difficult to diagnose.
[med-ed.virginia.edu]
Normal erythroblasts and megakaryocytes. AML with maturation (FAB classification M2) is the most common morphologic type correlating with t(8; 21).
[northshore.org]
Abnormal nuclear segmentation (pseudo Pelger-Huet nuclei) and/or cytoplasmic staining abnormalities. Increased eosinophil precursors. Reduced or absent monocytes.
[northshore.org]
A recent, detailed morphologic analysis of the abnormal promyelocytes in APL has led to a better appreciation of the cytologic variability of the leukemic cells in this disorder
[doi.org]
8 Erythroid precursors (erythroblasts) are not included in the blast count except in the rare instance of “pure” erythroleukemia.
[doi.org]
[…] myelodysplasia; acquired clonal cytogenetic abnormality in hematopietic cells; increased blast count (>5%) [ 3 ].
[intechopen.com]
Dyserythropoiesis Dysgranulopoiesis Dysmegakaryopoiesis Abnormality -Megaloblastic changes 1 -Lobulated nuclei in erythroblasts (kidney-shaped, bilobulated, multilobulated
[intechopen.com]
[…] childhood MDS require fulfillment of at least two of the following criteria: sustained, unexplained cytopenia (neutropenia, thrombocytopenia, or anemia); at least bilineage morphologic
[intechopen.com]
A recent, detailed morphologic analysis of the abnormal promyelocytes in APL has led to a better appreciation of the cytologic variability of the leukemic cells in this disorder
[doi.org]
8 Erythroid precursors (erythroblasts) are not included in the blast count except in the rare instance of “pure” erythroleukemia.
[doi.org]
abnormal erythroblasts as a result of cellular injury [ 76 ], and phagocytosis of erythroblasts by marrow macrophages [ 69, 76 ].
[malariajournal.biomedcentral.com]
[…] marrow cellularity tends to be normal or increased but there is ineffective erythropoiesis [ 66, 68, 76 ], as indicated by impaired iron utilization [ 69, 99 ], presence of morphologically
[malariajournal.biomedcentral.com]
[…] erythrocyte morphology DECIPHER:65 Methemoglobin Reductase Deficiency Abnormal erythrocyte morphology OMIM:250700 Bleeding Disorder, Platelet-Type, 15 Increased mean platelet
[mousephenotype.org]
[…] volume, Thrombocytopenia, Platelet anisocytosis OMIM:615193 Dyserythropoiesis, Congenital, With Ultrastructurally Normal Erythroblast Heterochromatin Anemia of inadequate
[mousephenotype.org]
Macrothrombocytopenia, Isolated, 2, Autosomal Dominant Macrothrombocytopenia OMIM:619840 Thrombocytopenia 4 Thrombocytopenia, Abnormal platelet volume OMIM:612004 Atr-16 syndrome Abnormal
[mousephenotype.org]
abnormalities of late erythroblasts in the bone marrow, including bi- and multinucleated cells.1,2 Individuals present with a variable degree of anemia with clinical and
[ncbi.nlm.nih.gov]
[…] erythropoiesis, cytokinesis Main Text The congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of rare genetic disorders of erythropoiesis with distinct morphologic
[ncbi.nlm.nih.gov]
PAS- Erythroblasts 33. Morphological abnormalities in MDSs 34.
[slideshare.net]
Striking morphologic abnormalities of erythroblasts, reviewed by Wickramasinghe and Wood (2005), include the 'Swiss-cheese' abnormality of erythroblasts on electron microscopy.Four
[mendelian.co]
It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis ( Tamary et al., 2005 ).
[mendelian.co]
Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities.
[mendelian.co]