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38 Possible Causes for Erythrocytes Decreased, Family History of Anemia, Polychromasia in Peripheral Blood Smear

  • Congenital Dyserythropoietic Anemia

    We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[ncbi.nlm.nih.gov] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[ncbi.nlm.nih.gov] CASE REPORT The patient was born to nonconsanguineous, healthy parents without a family history of anemia.[journals.lww.com]

  • Sideroblastic Anemia

    […] protoporphyrin), decreased ferrochelatase activity, and deletion of portions of the long arms of chromosomes 18 and 20.[ncbi.nlm.nih.gov] Blood Smear Peripheral blood smear images .[imagebank.hematology.org] Panel Description This is a next generation sequencing (NGS) test appropriate for individuals with clinical signs and symptoms, suspicion of, or family history of X-Linked[fulgentgenetics.com]

  • Hereditary Sideroblastic Anemia

    Males affected with sideroblastic anemia had growth retardation, hypochromic microcytic anemia, elevated serum iron, decreased unsaturated iron-binding capacity, increased[ncbi.nlm.nih.gov] Blood Smear Peripheral blood smear images .[imagebank.hematology.org] history.[orpha.net]

  • Congenital Hemolytic Anemia

    Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[ncbi.nlm.nih.gov] Laboratory The review of the peripheral blood smear revealed no evidence of the schistocytes or fragmented red cells.[medcraveonline.com] He is the second son of a non-consanguineous couple with unremarkable family history; there were no records of anemia, jaundice, gallstones or splenomegaly.[casesjournal.biomedcentral.com]

  • Pyruvate Kinase Deficiency

    decreased erythrocyte pyruvate kinase (PK) activity.[ncbi.nlm.nih.gov] Peripheral blood smear showed polychromasia, anisocytosis, tear drop cells, fragmented eyrtrocytes, and target cells.[ncbi.nlm.nih.gov] A family history of congenital hemolytic anemia or anemia of childhood is typically present.[clinicaladvisor.com]

  • Hemoglobin C Disease

    erythrocyte life span Double heterozygous sickling disorder Heinz bodies Hematopoietic maturation arrest Hemoglobin A1c above reference range Hemoglobin C disease Hemoglobin[icd9data.com] Sickle and target cells, polychromasia, and sometimes Howell–Jolly bodies are detected on peripheral blood smears. Results of sickle cell solubility tests are positive.[clinchem.aaccjnls.org] Hemoglobin C disease is suspected in all patients with a family history and evidence of a hemolytic anemia, particularly in adults with splenomegaly.[merckmanuals.com]

  • Anemia due to Glutathione Metabolism Disorder

    Addition of copper to normal erythrocytes led to increased autohemolysis, thermolability of hemoglobin, increased sensitivity to acetylphenylhydrazine, decreased erythrocyte[annals.org] The peripheral blood smear post-splenectomy often shows crenated or spiculated spherocytes and marked polychromasia.[clinicaladvisor.com] The mild form of glutathione synthetase deficiency (OMIM 231900) is associated with decreased erythrocyte glutathione levels and well-compensated hemolytic disease.[ommbid.mhmedical.com]

  • Acquired Spherocytosis

    These patients also have a proportionate decrease in protein 4.2 content on the erythrocyte membrane.[emedicine.medscape.com] […] hemoglobin concentration (MCHC) and the mean corpuscular volume (MCV), and to examine the peripheral blood smear for the presence of spherocytes and polychromasia. 17 Typically[pediatrics.aappublications.org] Blood 2015 125:3517; doi: A 73-year-old man without prior personal or family history of anemia developed a chronic hemolytic anemia characterized by an absolute reticulocyte[bloodjournal.org]

  • Autoimmune Hemolytic Anemia

    Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[jahjournal.org] […] include: Recent viral infections Taking medications that can cause autoimmune hemolytic anemia Cancer Collagen-vascular (autoimmune) disease Family history of hemolytic disease[cancercarewny.com]

  • Hemoglobin SC Disease

    The directed genetic abnormalities of human erythrocytes have found to decrease the susceptibility towards malaria parasites and the heterozygotes of abnormalities probably[doi.org] Sickle and target cells, polychromasia, and sometimes Howell–Jolly bodies are detected on peripheral blood smears. Results of sickle cell solubility tests are positive.[clinchem.aaccjnls.org] At a Glance A family history of anemia in the absence of iron deficiency should prompt consideration of a hemoglobinopathy, and a number of these appear in the differential[cancertherapyadvisor.com]

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