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36 Possible Causes for Erythrocytes Decreased, Haptoglobin Decreased, Polychromasia in Peripheral Blood Smear

  • Autoimmune Hemolytic Anemia

    Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[jahjournal.org] , and haptoglobin decreased to less than 8 mg/dL.[ncbi.nlm.nih.gov]

  • Microangiopathic Hemolytic Anemia

    […] than the decrease in number of erythrocytes. hypochromic microcytic anemia any anemia with microcytes that are hypochromic (reduced in size and in hemoglobin content); the[medical-dictionary.thefreedictionary.com] The peripheral blood smear revealed polychromasia, poikilocytosis, and many schistocytes. Bone marrow biopsy disclosed metastatic carcinoma.[ncbi.nlm.nih.gov] (decreased) • Reticulocyte count (appropriate) 21. • PT/PTT (normal; differentiates from DIC) • Stool tests – Shiga toxin, E. coli O157:H7 test • Urine Analysis – Hematuria[slideshare.net]

  • Pyruvate Kinase Deficiency

    decreased erythrocyte pyruvate kinase (PK) activity.[ncbi.nlm.nih.gov] Peripheral blood smear showed polychromasia, anisocytosis, tear drop cells, fragmented eyrtrocytes, and target cells.[ncbi.nlm.nih.gov] PAGE BREAK Patients who achieved at least 1 g/dL increase in hemoglobin also demonstrated an increase in haptoglobin and decrease in lactate dehydrogenase in the first weeks[healio.com]

  • Hemolytic Uremic Syndrome

    Anisocytosis, poikilocytosis, polychromasia, helmet cells, marked schistocytes, and rare platelets were observed in the peripheral blood smear, compatible with microangiopathic[ziaristionline.ro] […] hemolysis, which is characterized by elevated LDH levels, decreased haptoglobin, decreased hemoglobin, and/or the presence of schistocytes.[en.wikipedia.org] haptoglobin Elevated C-reactive protein level Hematuria on urinalysis Hemolysis on peripheral smear: burr cells, helmet cells Increased L-lactate dehydrogenase level Leukocytosis[aafp.org]

  • Atypical Hemolytic Uremic Syndrome

    Additionally the compound ACH-4471 significantly decreased C3 fragment deposition on paroxysmal nocturnal hemoglobinuria erythrocytes, indicating a reduced potential relative[ncbi.nlm.nih.gov] Anisocytosis, poikilocytosis, polychromasia, helmet cells, marked schistocytes, and rare platelets were observed in the peripheral blood smear, compatible with microangiopathic[ziaristionline.ro] […] hemolysis, which is characterized by elevated LDH levels, decreased haptoglobin, decreased hemoglobin, and/or the presence of schistocytes.[en.wikipedia.org]

  • Hemoglobin C Disease

    erythrocyte life span Double heterozygous sickling disorder Heinz bodies Hematopoietic maturation arrest Hemoglobin A1c above reference range Hemoglobin C disease Hemoglobin[icd9data.com] Sickle and target cells, polychromasia, and sometimes Howell–Jolly bodies are detected on peripheral blood smears. Results of sickle cell solubility tests are positive.[clinchem.aaccjnls.org] […] or absent haptoglobin, elevated LDH and unconjugated bilirubin, and elevated serum free hemoglobin.[clinicaladvisor.com]

  • Anemia due to Glutathione Metabolism Disorder

    Addition of copper to normal erythrocytes led to increased autohemolysis, thermolability of hemoglobin, increased sensitivity to acetylphenylhydrazine, decreased erythrocyte[annals.org] The peripheral blood smear post-splenectomy often shows crenated or spiculated spherocytes and marked polychromasia.[clinicaladvisor.com] Decreased Hemoglobinuria Liver function tests Elevated indirect bilirubin Scleral icterus Coombs’ test Negative TABLE 5 Symptoms and Laboratory Evaluation in Patients with[aafp.org]

  • Congenital Dyserythropoietic Anemia

    We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[ncbi.nlm.nih.gov] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[ncbi.nlm.nih.gov] The decrease of bilirubin and normal values of haptoglobin might be the concequence of diminished destruction of erythrocytes and their precursors.[ncbi.nlm.nih.gov]

  • Cold Agglutinin Disease

    The RBC count will be decreased due to doublet erythrocytes being counted as a single cell, thus resulting in a falsely high MCV. Hematocrit will also be lowered.[keralamedicaljournal.com] Reticulocytes and Spherocytes The results of the reticulocyte count are usually increased in patients with cold agglutinin disease, with polychromasia in the peripheral blood[web.archive.org] Decreased Cold agglutinin titers Present C3, C4, CH50 Decreased What imaging studies (if any) will be helpful in making or excluding the diagnosis of cold agglutinin disease[cancertherapyadvisor.com]

  • Nonimmune Hemolysis

    Premature destruction of erythrocytes occurs intravascularly or extravascularly. The etiologies of hemolysis often are categorized as acquired or hereditary.[aafp.org] blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[amboss.com] Patients with decreased haptoglobin levels also had decreases in platelet count over the same period.[omicsonline.org]

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