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49 Possible Causes for Erythrocytes Decreased, Hemolysis, Polychromasia in Peripheral Blood Smear

  • Autoimmune Hemolytic Anemia

    Laboratory investigations were suggestive of intravascular hemolysis, and on immuno-hematological evaluation it was diagnosed that the patient had autoantibody with mimicking[] Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[]

  • Cold Agglutinin Disease

    Lytic components of complement C5-C9 generally do not form on these cells, and intravascular hemolysis by complement is less likely to occur. [15] Hemolysis develops acutely[] The RBC count will be decreased due to doublet erythrocytes being counted as a single cell, thus resulting in a falsely high MCV. Hematocrit will also be lowered.[] Reticulocytes and Spherocytes The results of the reticulocyte count are usually increased in patients with cold agglutinin disease, with polychromasia in the peripheral blood[]

  • Atypical Hemolytic Uremic Syndrome

    Mechanical hemolysis is a frequent but usually harmless complication of aortic valve replacement. The most common reason is valvular leakage.[] Additionally the compound ACH-4471 significantly decreased C3 fragment deposition on paroxysmal nocturnal hemoglobinuria erythrocytes, indicating a reduced potential relative[] Anisocytosis, poikilocytosis, polychromasia, helmet cells, marked schistocytes, and rare platelets were observed in the peripheral blood smear, compatible with microangiopathic[]

  • Nonimmune Hemolysis

    […] acquired forms of thalassemia or erythrocytic membrane disorders, and hemolysis secondary to a dysfunctioning artificial (prosthetic) cardiac valve.[] Premature destruction of erythrocytes occurs intravascularly or extravascularly. The etiologies of hemolysis often are categorized as acquired or hereditary.[] blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[]

  • Congenital Hemolytic Anemia

    Chronic hemolysis often results in the formation of gallstones, and cholecystectomy is often indicated.[] Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[] Laboratory The review of the peripheral blood smear revealed no evidence of the schistocytes or fragmented red cells.[]

  • Microangiopathic Hemolytic Anemia

    Both the hemolysis and the thrombocytopenia spontaneously improved after the initiation of hemodialysis.[] […] than the decrease in number of erythrocytes. hypochromic microcytic anemia any anemia with microcytes that are hypochromic (reduced in size and in hemoglobin content); the[] The peripheral blood smear revealed polychromasia, poikilocytosis, and many schistocytes. Bone marrow biopsy disclosed metastatic carcinoma.[]

  • Uremic Anemia

    […] of hemolysis related to mitral valve repair when left untreated.[] […] in 38 hemodialysed patients was decreased and urea, creatinine and middle molecular substances had the effect on decreasing the osmotic resistance of erythrocyte in vitro[] Deficient erythropoietin synthesis, iron deficiency, blood loss, and a decreased erythrocyte half-life are the main contributors to anemia associated with CKD.[]

  • Acquired Spherocytosis

    Hemolysis can be extravascular, intravascular, or both.[] These patients also have a proportionate decrease in protein 4.2 content on the erythrocyte membrane.[] […] hemoglobin concentration (MCHC) and the mean corpuscular volume (MCV), and to examine the peripheral blood smear for the presence of spherocytes and polychromasia. 17 Typically[]

  • Pyruvate Kinase Deficiency

    We report here the case of a 1-year-old girl with mild hemolysis and PKD.[] decreased erythrocyte pyruvate kinase (PK) activity.[] To our knowledge, the present case is the first described in which the same condition is associated with hemolysis.[]

  • Congenital Dyserythropoietic Anemia

    […] examination showed continuous arrhythmia, systolic heart murmur, enlargement of spleen and liver, and pathologic hematological parameters, thus indicating an intravasal hemolysis[] We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[]

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