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183 Possible Causes for Erythrocytes Decreased, Hypercellular Bone Marrow

  • Hereditary Spherocytosis

    Defects in these proteins lead to a loss in RBC membrane cohesion and membrane surface area, resulting in erythrocyte sphering, decreased deformability and premature destruction[orpha.net] Stability studies with blood from HS patients showed a significant decrease in hyperchromic erythrocytes after 6 h storage.[ncbi.nlm.nih.gov] […] encode the red blood cell (RBC) membrane proteins erythrocytic 1 spectrin alpha chain, erythrocytic 1 spectrin beta chain, ankyrin-1, band 3 anion transport protein, and erythrocyte[orpha.net]

  • Paroxysmal Nocturnal Hemoglobinuria

    Complete donor chimerism was rapidly achieved in association with a rapid decrease in the proportion of PNH erythrocytes.[ncbi.nlm.nih.gov] These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually[bloodjournal.hematologylibrary.org] PFK, known to be decreased in the erythrocyte of neonates, showed normal activity, but it was lowest in the reticulocyte-rich layer.[pediatrics.aappublications.org]

  • Leukemia

    Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed[ncbi.nlm.nih.gov] Another important feature of bone marrow samples is its cellularity. Normal bone marrow contains hematopoietic (blood-forming) cells and fat cells.[web.archive.org] Marrow with too many blood-forming cells is said to be hypercellular. If too few of these cells are found, the marrow is called hypocellular.[web.archive.org]

  • Autoimmune Hemolytic Anemia

    Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma.[jmedicalcasereports.com] In patients with Evans syndrome, the mechanism of destruction of erythrocytes is thought to be similar to AIHA.[cancertherapyadvisor.com]

  • Acute Leukemia

    Acute Myeloid Leukemia - Erythrocyte decreased, Hb less than 10g/dl - Slightly Macrocytic because of the inability to compete the neoplastic cell for folate and vitB12 or[slideshare.net] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] […] platelet count, and anemia due to decreased erythrocyte count.[medical-dictionary.thefreedictionary.com]

  • Pernicious Anemia

    An elderly black man was admitted to our institution with macrocytic anemia, dysphagia, and significant weight loss. Results of an esophagogram were suggestive of achalasia. Gastric adenocarcinoma infiltrating the gastric cardia was seen on gastroscopy. The mode of presentation of gastric cancer in this case has[…][ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Because of such abnormal shapes, these cells are destroyed before releasing into the peripheral blood circulation, leading to cytopenias and hypercellular bone marrow.[lecturio.com] marrow hypercellularity, granulocyte proliferation, and decrease in erythroid precursors.[doi.org]

  • Acquired Spherocytosis

    These patients also have a proportionate decrease in protein 4.2 content on the erythrocyte membrane.[emedicine.medscape.com] Bone marrow biopsy was hypercellular with a decreased M:E ratio and dysplastic erythroid precursors.[bloodjournal.org] ), and (3) decreased production (reticulocytopenia).[cancertherapyadvisor.com]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[emedicine.medscape.com]

  • Sickle Cell Disease

    The directed genetic abnormalities of human erythrocytes have found to decrease the susceptibility towards malaria parasites and the heterozygotes of abnormalities probably[doi.org] The presence of HbA or hemoglobin F (HbF) within sickle erythrocytes decreases sickling and decelerates the polymerization process. 4, 5 Hydroxyurea (HU) is a chemotherapeutic[doi.org] When hemoglobin S is deprived of oxygen, it can polymerize, which is what is proposed to cause the "sickled" cells.[28] The sickled erythrocytes present a decreased deformability[en.wikipedia.org]

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