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12 Possible Causes for Erythrocytes Decreased, Intermittent Jaundice, Uric Acid Increased

  • Hereditary Spherocytosis

    Defects in these proteins lead to a loss in RBC membrane cohesion and membrane surface area, resulting in erythrocyte sphering, decreased deformability and premature destruction[] Abstract Hereditary spherocytosis is an autosomal dominant congenital hemolytic anemia due to defect in RBC membrane protein that commonly presents with intermittent jaundice[] Dubin-Johnson syndrome is a chronic, benign, intermittent jaundice, mostly of conjugated hyperbilirubinemia.[]

  • Primary Biliary Cirrhosis

    […] sedimentation rate Elevated bilirubin level, prolonged prothrombin time, and decreased albumin level: Indicate progression of disease to cirrhosis Thrombocytopenia: Indicates[] Twenty four hour urine demonstrated a low renal fractional tubular reabsorption of phosphate, increased fractional excretion of uric acid and generalized aminoaciduria.[] Reddy AN, Grosberg SJ, Wapnick S: Intermittent cholestatic jaundice and nonmetastatic prostatic carcinoma. Arch Intern Med 1977;137:1616–1618.[]

  • Refractory Megaloblastic Anemia

    […] degree of in effective erythropoiesis · Haptoglobins, Uric acid and alkaline phosphatase levels – Decreased. · Serum methylmalonate and homocystein levels - Vitamin B-12[] Lack of CTP, TMP, and UTP leads to a decreased nucleic acid synthesis and decreased erythrocyte formation resulting in Megaloblastic anemia.[] He has a fever and you note jaundice. You order an ultrasound of his abdomen and find multiple gallstones. Lab results: Hct .36 L/L; Hgb 120 g/L. PBS at right.[]

  • Hypercholesterolemia

    Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes. Am J Clin Nutr 2014 ; 99 : 79 -85.[] Gout or increased uric acid.[] We report the case of a male infant who had developed failure to thrive, jaundice, intermittent pruritus, and multiple diffuse symmetrical skin xanthomas at 1 year of age.[]

  • Hexokinase Deficiency

    Glucose consumption of the hexokinase-deficient cells was not appreciably decreased, probably because less of the potent inhibitor glucose-6-phosphate was present in the erythrocytes[] Uric Acid), and the patient presents Hyperuricemia.[] Intermittent jaundice and premature pigment gallstones are common. Splenomegaly is characteristic (palpable in 75% to 80% of cases).[]

  • Hemolytic Anemia due to a Disorder of Glycolytic Enzymes

    Defective PK catalysis in affected erythrocytes generally results in elevated concentrations of 2,3-diphosphoglycerate (2,3-DPG) and decreased ATP levels relative to cells[] However, inosine, which is a naturally occurring substance, increases plasma uric acid levels ( 38 ).[] jaundice and episodes of red/ dark urine Venous thrombosis in unusual locations (e.g., hepatic, cerebral, abdominal veins) Vasoconstriction : headache, pulmonary hypertension[]

  • Glucose-6-Phosphate Dehydrogenase Deficiency

    If t he fluidity of the cell interior or the surplus of cell surface is reduced, the “conformation instability” of the erythrocyte will decrease.[] An acid urine pH favors production of poorly soluble uric acid over the more soluble urate, increasing the risk for precipitation of intratubular uric acid crystals.[] To determine whether you have an inherited G6PD deficiency When a child experienced persistent jaundice as a newborn for unknown reasons; when you have had one or more intermittent[]

  • Beta-Ureidopropionase Deficiency

    Medicina (Kaunas). 2005;41 Suppl 1:65-8. [ PubMed:15901979 ] Lukaski HC: Low dietary zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory[] Plasmodium falciparum (malaria parasite) Along with many other disease causing parasites -Juvenile gout -No salvage of purines, therefore causing an increase in uric acid[] Intellectual disability, seizures, and periodic loss of balance and coordination (intermittent ataxia).[]

  • Ethambutol

    Drug: Aluminum-containing antacids can decrease absorption. Absorption: 70–80% absorbed from GI tract. Peak: 2–4 h.[] Alanine aminotransferase, aspartate aminotransferase, bilirubin, uric acid: increased levels Glucose: decreased level Patient monitoring Watch for serious adverse reactions[] A trial of intermittent rifampin and ethambutol in retreatment regimens. Scand J Respir Dis Suppl 1973; 84: 132-5.[]

  • Methyldopa

    Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, potassium, prolactin, sodium, uric acid: increased[] Side effects of methyldopa include anemia, which could result from decreased formation or accelerated death of circulating erythrocytes.[] A 55 year old woman had been treated for hypertension intermittently with methyldopa in the past and then developed jaundice and fatigue 7 days after it was restarted.[]

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