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14 Possible Causes for Erythrocytes Decreased, Neutrophil Count Decreased, Polychromasia in Peripheral Blood Smear

  • Autoimmune Hemolytic Anemia

    Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[] -Red cell morphology on review of the peripheral blood smear may demonstrate microspherocytes and polychromasia which are suggestive of a reactive reticulocytosis.[]

  • Pancytopenia

    One mechanism indicates direct effect of CMV on bone marrow cells leading to cellular injury and decrease of erythrocytes, lymphocytes, granulocytes, and platelets.[] Blood Film 1.RBC morphology ( size & shape) 2.WBC and RBC precursor 3.Platelets count & size 4.Abnormal increase or decrease granulation in Neutrophil 5.[] blood smear examination for which Leishman stain was used.[]

  • Sideroblastic Anemia

    […] protoporphyrin), decreased ferrochelatase activity, and deletion of portions of the long arms of chromosomes 18 and 20.[] Blood Smear Peripheral blood smear images .[] Erythropoietic protoporphyria (EPP) is an autosomal dominant disorder due to the decreased activity of ferrochelatase.[]

  • Congenital Dyserythropoietic Anemia

    We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[] The extent of the patient’s bone marrow hypocellularity, her haemoglobin concentration, and neutrophil and platelet counts place her disorder in the severe aplastic anemia[] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[]

  • Hereditary Sideroblastic Anemia

    […] and gama-interferon inhibit red cell production Shortened erythrocyte survival Autoimmune diseases may also cause antibody-mediated destruction CBC: Mild anemia (Hgb 9-11[] D720Genetic anomalies of leukocytes D721Eosinophilia D72810Lymphocytopenia D72818Other decreased white blood cell count D72819Decreased white blood cell count, unspecified[] Blood Smear Peripheral blood smear images .[]

  • Congenital Heinz Body Hemolytic Anemia

    erythrocyte life span Double heterozygous sickling disorder Heinz bodies Hematopoietic maturation arrest Hemoglobin A1c above reference range Hemoglobin C disease Hemoglobin[] Absolute Neutrophil Count (ANC) Use additional code for any associated: fever (780.6) mucositis (478.11, 528.00-528.09, 538, 616.81) Excludes: neutropenic splenomegaly (289.53[] The stained peripheral blood smear shows anisocytosis, poikilocytosis, basophilic stippling, polychromasia and, sometimes, hypochromia.[]

  • Normocytic Normochromic Anemia

    Microcytic anemia is characterized by a decrease in size of erythrocytes.[] Normocytic, normochromic with normal to increased neutrophils Normal to increased neutrophils and platelet count and M:E ratio increased This type of anaemia includes followings[] Peripheral blood smear shows: Microcytosis and hypochromasia. There is anisocytosis, poikilocytosis. There are pencil cells (elliptical RBCs).[]

  • Acquired Hemolytic Anemia

    Premature destruction of red cells occurs through two primary mechanisms: (1) decreased erythrocyte deformability that leads to red-cell sequestration and extravascular haemolysis[] D720Genetic anomalies of leukocytes D721Eosinophilia D72810Lymphocytopenia D72818Other decreased white blood cell count D72819Decreased white blood cell count, unspecified[] blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[]

  • Hemoglobin SC Disease

    The directed genetic abnormalities of human erythrocytes have found to decrease the susceptibility towards malaria parasites and the heterozygotes of abnormalities probably[] During hydroxyurea treatment, the white-cell count, absolute neutrophil count, and absolute reticulocyte count significantly decreased, reflecting the intended mild bone marrow[] Sickle and target cells, polychromasia, and sometimes Howell–Jolly bodies are detected on peripheral blood smears. Results of sickle cell solubility tests are positive.[]

  • Chronic Acquired Pure Red Cell Aplasia

    Leukocytes may be normal or slightly decreased at presentation.[] Furthermore, the maintenance of normal platelet and neutrophil counts throughout, the recovery of Hb on withdrawal of the TKI and decrease in Hb on the start of TKI helped[] blood smear showed anisocytosis, poikilocytosis, polychromasia and leukocytosis.[]

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