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22 Possible Causes for Erythrocytes Decreased, Osmotic Fragility Increased, Polychromasia in Peripheral Blood Smear

  • Congenital Hemolytic Anemia

    Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[ncbi.nlm.nih.gov] Laboratory The review of the peripheral blood smear revealed no evidence of the schistocytes or fragmented red cells.[medcraveonline.com] Osmotic fragility of fresh blood was increased, and postsplenectomy blood showed a fraction of extremely fragile cells.[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[jahjournal.org] -Red cell morphology on review of the peripheral blood smear may demonstrate microspherocytes and polychromasia which are suggestive of a reactive reticulocytosis.[oncologynurseadvisor.com]

  • Hemoglobin C Disease

    erythrocyte life span Double heterozygous sickling disorder Heinz bodies Hematopoietic maturation arrest Hemoglobin A1c above reference range Hemoglobin C disease Hemoglobin[icd9data.com] Sickle and target cells, polychromasia, and sometimes Howell–Jolly bodies are detected on peripheral blood smears. Results of sickle cell solubility tests are positive.[clinchem.aaccjnls.org] These findings suggest that the hemoglobin C molecules within C-C erythrocytes exist in an aggregated state.[ncbi.nlm.nih.gov]

  • Anemia due to Glutathione Metabolism Disorder

    Addition of copper to normal erythrocytes led to increased autohemolysis, thermolability of hemoglobin, increased sensitivity to acetylphenylhydrazine, decreased erythrocyte[annals.org] The peripheral blood smear post-splenectomy often shows crenated or spiculated spherocytes and marked polychromasia.[clinicaladvisor.com] The mild form of glutathione synthetase deficiency (OMIM 231900) is associated with decreased erythrocyte glutathione levels and well-compensated hemolytic disease.[ommbid.mhmedical.com]

  • Nonimmune Hemolysis

    Premature destruction of erythrocytes occurs intravascularly or extravascularly. The etiologies of hemolysis often are categorized as acquired or hereditary.[aafp.org] blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[amboss.com] Osmotic fragility can be increased due to the presence of spherocytes.[mayomedicallaboratories.com]

  • Acquired Spherocytosis

    These patients also have a proportionate decrease in protein 4.2 content on the erythrocyte membrane.[emedicine.medscape.com] […] hemoglobin concentration (MCHC) and the mean corpuscular volume (MCV), and to examine the peripheral blood smear for the presence of spherocytes and polychromasia. 17 Typically[pediatrics.aappublications.org] Studies on red cells revealed: (i) presence of spherocytes; (ii) increased osmotic fragility; (iii) abnormalities in red cell membrane protein composition; (iv) reduced membrane‐cytoskeleton[deepdyve.com]

  • Pyruvate Kinase Deficiency

    decreased erythrocyte pyruvate kinase (PK) activity.[ncbi.nlm.nih.gov] Peripheral blood smear showed polychromasia, anisocytosis, tear drop cells, fragmented eyrtrocytes, and target cells.[ncbi.nlm.nih.gov] Partial PK deficiency was associated with decreased red cell ATP content and markedly increased osmotic fragility.[ncbi.nlm.nih.gov]

  • Congenital Heinz Body Hemolytic Anemia

    erythrocyte life span Double heterozygous sickling disorder Heinz bodies Hematopoietic maturation arrest Hemoglobin A1c above reference range Hemoglobin C disease Hemoglobin[icd9data.com] The stained peripheral blood smear shows anisocytosis, poikilocytosis, basophilic stippling, polychromasia and, sometimes, hypochromia.[mayomedicallaboratories.com] osmotic fragility Heterozygous individuals are symptomless Unstable hemoglobin disorders Contain amino acid changes in internal portions of he hgb chains leading to decreased[slideplayer.com]

  • Hemolytic Anemia

    In general, any condition which shortens erythrocyte survival or decreases mean erythrocyte age, such as autoimmune hemolytic anemia, hereditary spherocytosis and elliptocytosis[academic.oup.com] Mean corpuscular volume was 96 fl, and the reticulocyte count was 11%, with marked polychromasia on peripheral smear.[care.diabetesjournals.org] The erythrocytes have increased osmotic fragility and are abnormally permeable to sodium ions.[icd9data.com]

  • Normocytic Normochromic Anemia

    Microcytic anemia is characterized by a decrease in size of erythrocytes.[innvista.com] Peripheral blood smear shows: Microcytosis and hypochromasia. There is anisocytosis, poikilocytosis. There are pencil cells (elliptical RBCs).[labpedia.net] Increase deformability 4. Which of the following is not associated with hereditary spherocytosis? A. Increased osmotic fragility B. An MCHC greater than 36% C.[proprofs.com]

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