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44 Possible Causes for Erythrocytes Decreased, Polychromasia in Peripheral Blood Smear

  • Congenital Dyserythropoietic Anemia

    We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[ncbi.nlm.nih.gov] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[ncbi.nlm.nih.gov] The decrease of bilirubin and normal values of haptoglobin might be the concequence of diminished destruction of erythrocytes and their precursors.[ncbi.nlm.nih.gov]

  • Cold Agglutinin Disease

    The RBC count will be decreased due to doublet erythrocytes being counted as a single cell, thus resulting in a falsely high MCV. Hematocrit will also be lowered.[keralamedicaljournal.com] Reticulocytes and Spherocytes The results of the reticulocyte count are usually increased in patients with cold agglutinin disease, with polychromasia in the peripheral blood[web.archive.org] The microaggregates of erythrocyte are counted as single cells and large clumps of cells are excluded from the count, which lead to decreased RBC count (9).[biochemia-medica.com]

  • Autoimmune Hemolytic Anemia

    Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[jahjournal.org] Red blood cell agglutination, polychromasia, target cells and spherocytes were seen on a peripheral smear.[doi.org]

  • Acquired Sideroblastic Anemia

    […] than the decrease in number of erythrocytes. hypochromic microcytic anemia any anemia with microcytes that are hypochromic (reduced in size and in hemoglobin content); the[medical-dictionary.thefreedictionary.com] Blood Smear Peripheral blood smear images .[imagebank.hematology.org] The total iron-binding capacity of the cells is normal to decreased. Stainable marrow hemosiderin is increased.[en.wikipedia.org]

  • Hereditary Sideroblastic Anemia

    Males affected with sideroblastic anemia had growth retardation, hypochromic microcytic anemia, elevated serum iron, decreased unsaturated iron-binding capacity, increased[ncbi.nlm.nih.gov] Blood Smear Peripheral blood smear images .[imagebank.hematology.org] […] and gama-interferon inhibit red cell production Shortened erythrocyte survival Autoimmune diseases may also cause antibody-mediated destruction CBC: Mild anemia (Hgb 9-11[quizlet.com]

  • Sideroblastic Anemia

    […] protoporphyrin), decreased ferrochelatase activity, and deletion of portions of the long arms of chromosomes 18 and 20.[ncbi.nlm.nih.gov] Blood Smear Peripheral blood smear images .[imagebank.hematology.org] Erythropoietic protoporphyria (EPP) is an autosomal dominant disorder due to the decreased activity of ferrochelatase.[ommbid.mhmedical.com]

  • Nonimmune Hemolysis

    Premature destruction of erythrocytes occurs intravascularly or extravascularly. The etiologies of hemolysis often are categorized as acquired or hereditary.[aafp.org] blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[amboss.com] The diagnosis is established by reticulocytosis, increased unconjugated bilirubin and lactate dehydrogenase, decreased haptoglobin, and peripheral blood smear findings.[aafp.org]

  • Congenital Hemolytic Anemia

    Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[ncbi.nlm.nih.gov] Laboratory The review of the peripheral blood smear revealed no evidence of the schistocytes or fragmented red cells.[medcraveonline.com] blood smear of Congenital Hemolytic Anemia Describe the extent of central pallor of a normal RBC T/F: There is increased reticulocytosis and polychromasia in Congenital Hemolytic[brainscape.com]

  • Sickle Cell Crisis

    A: Sickle-shaped erythrocytes cause cellular blockage in small vessels. B: Sickle-shaped erythrocytes cause decreased organ perfusion.[nurseslabs.com] Haematological indices revealed marked reticulocytosis (mean 14.39 (6.40)%) beyond the steady state levels (mean 6.41 (2.45)%), polychromasia on blood smears, and increased[adc.bmj.com] A decrease in irreversibly sickled erythrocytes in sickle cell anemia patients given vitamin E. Am J Clin Nutr. 1980;33:968–971. 20. Natta CL, Reynolds RD.[health.cvs.com]

  • Microangiopathic Hemolytic Anemia

    […] than the decrease in number of erythrocytes. hypochromic microcytic anemia any anemia with microcytes that are hypochromic (reduced in size and in hemoglobin content); the[medical-dictionary.thefreedictionary.com] The peripheral blood smear revealed polychromasia, poikilocytosis, and many schistocytes. Bone marrow biopsy disclosed metastatic carcinoma.[ncbi.nlm.nih.gov] Hemosiderinuria is seen in chronic intravascular hemolysis. 4) Examination of blood smear: Careful examination of peripheral blood smear by an experienced person provides[bioline.org.br]

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