Erythrocytosis: Causes & Reasons

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Possible Causes for Erythrocytosis

Myeloproliferative Disease

These data suggest that erythrocytosis and granulocytosis in JAK2(V617F) mice are the net result of a complex interplay between cell intrinsic and extrinsic factors. [ncbi.nlm.nih.gov]

There have been no prospective national studies to estimate the incidence or outcomes of myeloproliferative disorders, persistent thrombocytosis or erythrocytosis in pregnancy [npeu.ox.ac.uk]

Our data seem to indicate that both thrombocytosis and erythrocytosis resembled primary forms in these subjects; however, none of them suffered serious thrombotic and/or hemorrhagic [ncbi.nlm.nih.gov]

Paraneoplastic Syndrome

Paraneoplastic erythrocytosis was defined as a hemoglobin level greater than or equal to 16.7 g/dL in the absence of other causes of secondary erythrocytosis such as chronic [hindawi.com]

Erythrocytosis is common in cancers of the liver, kidney, adrenal glands, lung, thymus, and CNS as well as in gynecologic tumors and myosarcomas. [emedicine.medscape.com]

In contrast, survival of patients with paraneoplastic erythrocytosis was not significantly reduced. [hindawi.com]

Polycythemia Vera

In patients with only an elevated hematocrit, polycythemia vera may be present, but secondary erythrocytosis Secondary Erythrocytosis Secondary erythrocytosis is erythrocytosis [msdmanuals.com]

Unexpectedly, the symptom of erythrocytosis disappeared after the surgery. [ncbi.nlm.nih.gov]

Furthermore, in addition to presenting with isolated thrombocytosis, polycythemia vera can present with just erythrocytosis alone, erythrocytosis and splenomegaly, erythrocytosis [cancertherapyadvisor.com]

Metastatic Renal Cell Carcinoma

Tumor cells may produce erythropoietin and provoke erythrocytosis. [symptoma.com]

[…] abdominal mass;[9] malaise, which is a general feeling of unwellness;[9] weight loss and/or loss of appetite;[10] anaemia resulting from depression of erythropoietin;[8] erythrocytosis [en.wikipedia.org]

Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma is occasionally associated with erythrocytosis, hypothesized to result from tumoral production of erythropoietin. [ncbi.nlm.nih.gov]

[…] micro- or macroscopic hematuria occurs in 60% of patients Complete blood count (CBC) – patients may have anemia of chronic inflammation (normo- or microcytic), some have erythrocytosis [clinicaladvisor.com]

Eisenmenger Syndrome

When bunazosin was stopped, the erythrocytosis increased, but when it was resumed, the erythrocytosis and general fatigue diminished. [ncbi.nlm.nih.gov]

Patients with either severe secondary erythrocytosis (>220g/L) or anaemia ( CONCLUSIONS: Thrombocytopaenia significantly increased the risk of mortality in ES. [ncbi.nlm.nih.gov]

≥ 25 mmHg RVH develops in compensation → shunting reverse in blood flow to become right-to-left → cyanosis and respiratory distress clinically, this results in secondary erythrocytosis [medbullets.com]

Polycythemia

Convert to ICD-10-CM : 289.0 converts directly to: 2015/16 ICD-10-CM D75.1 Secondary polycythemia Approximate Synonyms Erythrocytosis Erythrocytosis due to tobacco use or [icd9data.com]

][11] HIF2α erythrocytosis: Gain-of-function mutations in HIF2α are associated with autosomal dominant erythrocytosis[12] and pulmonary hypertension.[13] Relative polycythemia [en.wikipedia.org]

# 133100 ERYTHROCYTOSIS, FAMILIAL, 1; ECYT1 Alternative titles; symbols POLYCYTHEMIA, PRIMARY FAMILIAL AND CONGENITAL; PFCP ERYTHROCYTOSIS, AUTOSOMAL DOMINANT BENIGN ORPHA [ncbi.nlm.nih.gov]

Post-Polycythemia Vera Myelofibrosis

We describe how treatment with a JAK1/2 inhibitor, ruxolitinib, led to the rapid amelioration of marrow fibrosis, erythrocytosis and thrombocytopenia in a 77-year-old man [ncbi.nlm.nih.gov]

[…] see secondary erythrocytosis). [msdmanuals.com]

Increased production confined to the RBC line is termed erythrocytosis; isolated erythrocytosis may occur with polycythemia vera but is more commonly due to other causes [msdmanuals.com]

Red Blood Cell Disorder

There are two types of erythrocytosis. [clearviewcancer.com]

[…] vera; Myeloproliferative disorder; Erythremia; Splenomegalic polycythemia; Vaquez's disease; Osler's disease; Polycythemia with chronic cyanosis - Myelopathic polycythemia; Erythrocytosis [sutterhealth.org]

Hemosiderinuria Hereditary pyropoikilocytosis HFE hereditary haemochromatosis I Iron deficiency L Latent iron deficiency M McLeod syndrome Methemoglobinemia Microcytosis Myomatous erythrocytosis [en.wikipedia.org]

Polycythemia Neonatorum

[…] conjunctivitis Inclusion: Ophthalmia neonatorum due to gonococcus| D45 Polycythemia vera excludes: familial polycythemia (D75.0)| secondary polycythemia (D75.1)| D75.0 Familial erythrocytosis [codelay.com]

] [11] HIF2α erythrocytosis: Gain-of-function mutations in HIF2α are associated with autosomal dominant erythrocytosis [12] and pulmonary hypertension. [13] Relative polycythemia [en.wikipedia.org]

[…] secondary) D75.1 ICD-10-CM Diagnosis Code D75.1 Secondary polycythemia 2016 2017 2018 2019 Billable/Specific Code Applicable To Acquired polycythemia Emotional polycythemia Erythrocytosis [icd10data.com]

Gaisbock Syndrome

Synonym: spurious erythrocytosis ; spurious polycythemia ; stress erythrocytosis Gaisböck, (Gaisbock), Felix, German physician, 1868-1955. [medical-dictionary.thefreedictionary.com]

Synonym: spurious erythrocytosis; spurious polycythemia; stress erythrocytosis Gaisböck, (Gaisbock), Felix, German physician, 1868-1955. [medical-dictionary.thefreedictionary.com]

Secondary Polycythemia

This case illustrates the rarely reported association of the nephrotic syndrome and erythrocytosis, and the resolution of erythrocytosis with improvement of nephrotic syndrome [ncbi.nlm.nih.gov]

[…] to more hypoxia and more erythrocytosis and so on. [ncbi.nlm.nih.gov]

Related Concepts SNOMET-CT Gaisbock's syndrome (disorder) Erythrocytosis due to hydronephrosis (disorder) Erythrocytosis due to uterine myoma (disorder) Erythrocytosis due [icd.codes]

Stress Polycythemia

1967 19 Stress erythrocytosis. 61 DAMESHEK W 13032198 1953 [malacards.org]

Called also benign or stress erythrocytosis, GaisbÑ†ck disease, pseudopolycythemia, and benign, chronic relative, hypertonic, or spurious p. Medical dictionary. 2011. [medicine.academic.ru]

Chronic relative polycythemia or erythrocytosis has been variously called Gaisbock syndrome, stress erythrocytosis, benign polycythemia or erythrocytosis, benign erythrocytosis [enotes.tripod.com]

Erythrocytosis

Recently, a HIF-2 alpha Gly537Trp mutation was identified in a family with erythrocytosis. [ncbi.nlm.nih.gov]

[…] concentration, or secondary, when the erythrocytosis is the result of an upregulation of Epo production. [ncbi.nlm.nih.gov]

Erythrocytosis in ESRD patients is very rare. [ncbi.nlm.nih.gov]

Cyanotic Congenital Heart Disease

Headaches and blurred vision in patients with cyanotic congenital heart disease and secondary erythrocytosis may be attributed to hyperviscosity and traditionally were treated [ncbi.nlm.nih.gov]

Secondary erythrocytosis of cyanotic congenital heart disease (CCHD) is pathologically different from primary erythrocytosis of polycythemia vera (PV). [ncbi.nlm.nih.gov]

We describe the successful use of hydroxyurea (hydroxycarbamide) in four patients with uncorrected CCHD and symptomatic secondary erythrocytosis. [ncbi.nlm.nih.gov]

Primary Male Hypogonadism

Erythrocytosis (increase in proportion of red blood cells) is an adverse effect of testosterone-replacement therapy. [medivizor.com]

Erythrocytosis. Unstable severe congestive heart failure (class III or IV). [touchendocrinology.com]

Erythrocytosis – avoid if pre-existing erythrocytosis is present (e.g., hematocrit >50%). [clinicaladvisor.com]

Hemoglobin Yakima

In 1954 a then 31-yr-old male was found to have erythrocytosis. Over the ensuing decade he received 72 mCi32P. In 1964 his daughters were found to have erythrocytosis. [ncbi.nlm.nih.gov]

Abstract In 1954 a then 31-yr-old male was found to have erythrocytosis. Over the ensuing decade he received 72 mCi32P. [bloodjournal.org]

erythrocytosis, androgen therapy, Cushing's disease, truncation of EPOR and hypertransfusion, in addition to the familial erythrocytosis and idiopathic erythrocytosis. [6 [sjmms.net]

Hemoglobin Chesapeake

[…] vera or erythrocytosis of chronic lung disease. [hindawi.com]

Erythrocytosis due to BPGM deficiency is very rare. [mdedge.com]

[…] and alpha 1-globin gene variants in heterozygotes. [ PMID 17486491 ] Hb J-Cape Town [alpha92(FG4)Arg-->Gln (alpha1), CGG-->CAG] in Southern Italy found in a patient with erythrocytosis [snpedia.com]

Familial Polycythemia

erythrocytosis, androgen therapy, Cushing's disease, truncation of EPOR and hypertransfusion, in addition to the familial erythrocytosis and idiopathic erythrocytosis. [6 [sjmms.net]

Familial erythrocytosis-2 has characteristics of both primary and secondary erythrocytosis (Prchal, 2005). [bloodgenetics.com]

Familial erythrocytosis: molecular links to red blood cell control Haematologica July 2008 93: 963-967; doi: 10.3324/haematol.13250 Familial or hereditary erythrocytosis is [haematologica.org]

Decreased Oxygen Carrying Capacity

This study indicates that smoking causes mild erythrocytosis comparable to that seen in spurious or stress polycythemia. [bloodjournal.org]

An erythrocytosis is the consequence of too many red cells; this results in hemoglobin levels above normal. [nurse-anesthesia.org]

Dehydration ( heat exhaustion, no available source of fluids) Low availability of oxygen ( smoking, high altitude, pulmonary fibrosis) Genetic (congenital heart diseases) Erythrocytosis [emedicinehealth.com]

Hypogonadism

Erythrocytosis. Unstable severe congestive heart failure (class III or IV). [touchendocrinology.com]

Erythrocytosis - avoid if pre-existing erythrocytosis is present (e.g., hematocrit >50%). [clinicaladvisor.com]

Adverse effects of testosterone replacement include: Acne Prostate enlargement Stimulation of the growth of breast cancer or prostate cancer Sleep apnoea Heart failure Erythrocytosis [dermnetnz.org]

Hemoglobinopathy

The rare hemoglobinopathies with abnormal oxygen binding are usually characterized by erythropoietin-mediated erythrocytosis. [ncbi.nlm.nih.gov]

Hemoglobin e trait Hemoglobin low Hemoglobin O-Arab trait Hemoglobin very high Hemoglobin Zurich disease Hemoglobinopathy Hemoglobinopathy with cyanosis Hemoglobinopathy with erythrocytosis [icd9data.com]

Certain forms may even be accompanied by erythrocytosis, hemoglobinemia and increased hematokrit (please also refer to pathophysiology). [symptoma.com]

Hemoglobin E Disease

Hematological investigations of these individuals reveal a mild microcytosis, hypochromia and erythrocytosis as seen with the β-thalassemia trait. [jdrntruhs.org]

Hematological investigations of these individuals reveal mild microcytosis, hypochromia and erythrocytosis as seen with the β-thalassemia trait. [ijpmonline.org]

HbE disease causes only a mild, usually asymptomatic anemia with microcytosis and erythrocytosis. [jlponline.org]

Congenital Heinz Body Hemolytic Anemia

Finazzi et al., Idiopathic erythrocytosis and other non-clonal polycythemias. Best Pract Res Clin Haematol. 19, 471 (2006) G. Weiss et al.,) Anemia of Chronic Disease. [charite.de]

[…] conditions cannot occur together, such as a congenital form versus an acquired form of the same condition. familial polycythemia ( ICD-10-CM Diagnosis Code D75.0 Familial erythrocytosis [icd10data.com]

Cerebellar Hemangioblastoma

Cerebellar hemangioblastoma is a rare cause of secondary erythrocytosis. [ncbi.nlm.nih.gov]

A patient with cerebellar hemangioblastoma and secondary erythrocytosis is presented. [ncbi.nlm.nih.gov]

There is erythrocytosis with no associated splenomegaly or increase in the white cell or platelet count. [neurosurgery.me]

Male Hypogonadism

Contraindications to testosterone-replacement therapy include prostate and breast cancers, uncontrolled congestive heart failure, severe lower-urinary-tract symptoms, and erythrocytosis [ncbi.nlm.nih.gov]

Erythrocytosis. Unstable severe congestive heart failure (class III or IV). [touchendocrinology.com]

Pickwickian Syndrome

[…] sounds Low voltage QRS complexes Diagnosis : Alveolar hypoventilation during wakefullness Chronic hypercapnic, hypoxic respiratory failure Respiratory acidosis Secondary erythrocytosis [medlibes.com]

It is named after the fat boy Joe in The Pickwick Papers of Charles Dickens. pickwickian syndrome alveolar hypoventilation, somnolence and erythrocytosis associated with extreme [medical-dictionary.thefreedictionary.com]

Complications of obesity hypoventilation syndrome include pulmonary hypertension ; right heart failure, also known as cor pulmonale; and secondary erythrocytosis. [nhlbi.nih.gov]

Hemolytic Anemia due to Glycolytic Enzyme Deficiency

Journal Ann Pharmacother 44:1327-9 (2010) DOI: 10.1345/aph.1P030 Reference PMID: 15054810 Authors Hoyer JD, Allen SL, Beutler E, Kubik K, West C, Fairbanks VF Title Erythrocytosis [genome.jp]

Deficiencies of BPGM and bisphosphoglycerate phosphatase are associated with mild erythrocytosis secondary to virtual absence of 2,3-DPG. [ommbid.mhmedical.com]

D7389Other diseases of spleen D739Disease of spleen, unspecified D740Congenital methemoglobinemia D748Other methemoglobinemias D749Methemoglobinemia, unspecified D750Familial erythrocytosis [cms.gov]

Thrombocytosis

Primary causes may be suspected if there is an associated erythrocytosis or leucocytosis. Complications of primary MPNs include arterial or venous occlusive events. [apps.nhslothian.scot]

[…] is found in the vast majority of patients with polycythemia vera (PV) and this change is proposed to be one of diagnostic tools for PV, 1 while the presence of idiopathic erythrocytosis [nature.com]

Control subjects include healthy individuals and patients with secondary erythrocytosis who did not carry the JAK2 (V617F) mutation. [dx.doi.org]

Hemoglobin Lepore-Beta-Thalassemia Syndrome

Many are clinically harmless and others cause symptoms including microcytosis, sickling disorders, hemolysis, erythrocytosis, cyanosis/hypoxia, long-standing or familial anemia [mayomedicallaboratories.com]

Hereditary Persistence of Fetal Hemoglobin: pathology Absence of α- & β-chains ↑ γ-chains 3 types: Black Swiss Greek Hereditary Persistence of Fetal Hemoglobin: Lab findings M/H erythrocytosis [studyblue.com]