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658 Possible Causes for Erythrocytosis, Hypoxia

  • Polycythemia Vera

    While hypoxia has been demonstrated in some patients with polycythemia vera (4-6) it has been attributed in these instances to co-existent cardiorespiratory disease (1, 6)[annals.org] Unexpectedly, the symptom of erythrocytosis disappeared after the surgery.[ncbi.nlm.nih.gov] […] cause upregulation of the hypoxia signaling pathway and its target genes including erythropoietin (EPO) and its receptor (EPOR).[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    Secondary PolycythemiaSecondary PolycythemiaAppropriate EPO (tissue/kidney hypoxia)Appropriate EPO (tissue/kidney hypoxia)pulmonary diseasepulmonary diseasehigh altitudehigh[slideshare.net] These data suggest that erythrocytosis and granulocytosis in JAK2(V617F) mice are the net result of a complex interplay between cell intrinsic and extrinsic factors.[ncbi.nlm.nih.gov] Overproduction occurs in hypoxia (eg, pulmonary disease, high altitude, smoking-related carboxyhemoglobin, cyanotic cardiac disease, and methemoglobinemia), tumors (eg, kidney[clevelandclinicmeded.com]

  • Secondary Polycythemia

    The expression of hypoxia-inducible factor (HIF)-1α, which is undetectable in normal kidney, was observed in the renal tubule epithelium compressed by lymphoblastic cells.[ncbi.nlm.nih.gov] Out of these 53 patients, 28 (53%) patients had PV and 25 (47%) patients had secondary erythrocytosis.[bloodjournal.org] Leukemia kidney infiltration can cause secondary polycythemia by activating hypoxia-inducible factor (HIF) pathway . European Journal of Pediatrics , 172 (6), 829-832.[keio.pure.elsevier.com]

  • Cyanotic Congenital Heart Disease

    In contrast to the diminished ventilatory response to hypoxia which has been found at rest in cyanotic congenital heart disease, hyperventilation was noted on exercise in[clinsci.org] Secondary erythrocytosis of cyanotic congenital heart disease (CCHD) is pathologically different from primary erythrocytosis of polycythemia vera (PV).[ncbi.nlm.nih.gov] Chronic exposure to hypoxia in patients with CCHD could increase the risk for developing PHEO/PG.[endocrine-abstracts.org]

  • Polycythemia

    While hypoxia has been demonstrated in some patients with polycythemia vera (4-6) it has been attributed in these instances to co-existent cardiorespiratory disease (1, 6)[annals.org] ERYTHROCYTOSIS AND POLYCYTHEMIA VERA 1. In patients with erythrocytosis, which of the following is not characteristic of polycythemia vera?[mdedge.com] As compared with sea-level controls and non-CMS subjects who responded to hypoxia by increasing their RBCs modestly or not at all, respectively, CMS cells increased theirs[ncbi.nlm.nih.gov]

  • Erythrocytosis

    Abstract As a typical model of hypoxia‑induced excessive erythrocytosis, high altitude polycythemia (HAPC) results in microcirculation disturbance, aggravates tissue hypoxia[ncbi.nlm.nih.gov] In addition, EPO levels are a very useful tool in recognizing the nature of erythrocytosis.[symptoma.com] We used urine hypoxia-inducible factor-2 alpha (HIF-2α) levels to evaluate whether there is local tissue hypoxia in renal allograft.[ncbi.nlm.nih.gov]

  • Eisenmenger Syndrome

    This helped achieve a reduction of shunt, improvement of hypoxia and reduction of pulmonary pressures.[ncbi.nlm.nih.gov] When bunazosin was stopped, the erythrocytosis increased, but when it was resumed, the erythrocytosis and general fatigue diminished.[ncbi.nlm.nih.gov] Chronic hypoxia caused by Eisenmenger syndrome may result in polycythemia with resultant hyperviscosity and bilateral central retinal vein occlusion.[ncbi.nlm.nih.gov]

  • Familial Polycythemia

    So periodic hypoxia in long term can induce erythropoietin production causing polycythemia[16].[explainmedicine.com] In some cases, the cause of erythrocytosis is unknown. Familial erythrocytosis can have different inheritance patterns depending on the gene involved.[ghr.nlm.nih.gov] Mutations of that von Hippel-Lindau gene cause increased transcription of hypoxia-inducible genes. This condition is quite benign. Systematic References: 1.[moldiag.com]

  • Hypoventilation

    This kind of exercise may be worth using for performing repeated sprint training in hypoxia. KEYWORDS: Exercise; Hypoventilation; Hypoxemia; Hypoxia; Repeated sprints[ncbi.nlm.nih.gov] Complications of obesity hypoventilation syndrome include pulmonary hypertension ; right heart failure, also known as cor pulmonale; and secondary erythrocytosis.[nhlbi.nih.gov] Complications of obesity hypoventilation syndrome include pulmonary hypertension ; right heart failure , also known as cor pulmonale; and secondary erythrocytosis .[nhlbi.nih.gov]

  • Stress Polycythemia

    Polycythemia types Secondary to various physiopathologic mechanisms, usually hypoxia or erythropoietin secretion Neoplastic, ie polycythemia vera, see there. ;. pol·y·cy·the[medical-dictionary.thefreedictionary.com] Called also benign or stress erythrocytosis, Gaisbцck disease, pseudopolycythemia, and benign, chronic relative, hypertonic, or spurious p. Medical dictionary. 2011.[medicine.academic.ru] Detection and accurate diagnosis of erythrocytosis is important regardless of its cause.[mhmedical.com]

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