Exacerbation: Causes & Reasons

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Possible Causes for Exacerbation

Opioid Dependence

Repeated observations of neurons during 48 h exposure to combinations of Tat, equimolar concentrations (500 nM) of morphine, methadone, or buprenorphine exacerbated neurotoxicity [ncbi.nlm.nih.gov]

For example, opioid withdrawal symptoms may mimic the hypervigilance and exacerbated startle response of patients with PTSD. [ncbi.nlm.nih.gov]

Exacerbating that gap was a geographic mismatch. [latimes.com]

Acute Bronchitis

RESULTS: Antibiotic prescribing rates were high in both acute bronchitis (84%) and in exacerbations of COPD (53%). [ncbi.nlm.nih.gov]

Abstract In managing acute bronchitis, pneumonia or an exacerbation of underlying chronic bronchitis should be excluded. [ncbi.nlm.nih.gov]

This syndrome should be distinguished from the common cold, an acute exacerbation of chronic bronchitis, and acute asthma as the cause of acute cough. [ncbi.nlm.nih.gov]

Bronchitis

exacerbations per participant. [dx.doi.org]

[…] of exacerbation. [doi.org]

Medical condition: Acute exacerbation of chronic-obstructive pulmonary disease. [clinicaltrialsregister.eu]

Viral Lower Respiratory Infection

Acute exacerbations of chronic bronchitis Acute exacerbations of chronic bronchitis are often due to viral infection and do not require treatment with antimicrobials. [apps.who.int]

AECOPD = Acute exacerbation of COPD. [karger.com]

Final diagnoses were: 49 patients with CAP, 30 COPD patients with acute exacerbations, and 30 patients with acute bronchitis. [karger.com]

Moraxella Catarrhalis

These included 13 stable and 22 exacerbation samples. [dovepress.com]

exacerbations were likely caused by M. catarrhalis. [ncbi.nlm.nih.gov]

Tested (%) Intensity of Immune Response,  Median % Increase (IQR) Exacerbation Colonization p Value Exacerbation Colonization p Value Serum IgG* 31/54 (57.4) 23/52 (44.2) [atsjournals.org]

Bronchial Asthma

[…] of severe asthma exacerbation in these groups. [ncbi.nlm.nih.gov]

Summary Epidemiologic studies indicate that work-exacerbated asthma is common. [doi.org]

Epidemiologic studies indicate that work-exacerbated asthma is common. [ncbi.nlm.nih.gov]

Geographic Tongue

The disorder is characterized by exacerbations and remissions. [ncbi.nlm.nih.gov]

The disease is characterized by periods of exacerbation and remission during which the lesions heal without residual scar formation. [jiaomr.in]

This lesions change in size and shape with time, and are characterized by periods of exacerb… Publisher Full Text Association between geographic tongue and psoriasis: A systematic [unboundmedicine.com]

Chronic Obstructive Pulmonary Disease

The mechanisms of COPD exacerbation are complex. [ncbi.nlm.nih.gov]

Long-term treatment with macrolides has recently been shown to reduce COPD exacerbations in doses lower than bactericidal doses. [ncbi.nlm.nih.gov]

[…] of exacerbation. [doi.org]

Atopic Dermatitis

None of the subjects exhibited exacerbation of atopic dermatitis at the wrist area after wearing the actigraphy monitors for 7 days. No adverse events were reported. [ncbi.nlm.nih.gov]

Atopic dermatitis (AD) is a common chronic inflammatory skin disease with epidermal barrier defects which leads to dry skin that is easily disturbed by external exacerbating [ncbi.nlm.nih.gov]

Abstract Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. [ncbi.nlm.nih.gov]

Pulmonary Emphysema

[…] no exacerbations. [atsjournals.org]

Thus, the exacerbation of local inflammatory process in the vascular and lung tissue ensues due to a generation of reactive oxygen species, resulting in further lipoprotein [ncbi.nlm.nih.gov]

The only role for systemic steroid therapy in COPD is for 5-10 days during an acute exacerbation. [columbiasurgery.org]

Rosacea

Albeit rarely, exacerbation of rosacea by topical 5-FU treatment has been described when 5-FU was introduced as a topical treatment for actinic keratosis.Conclusion Topical [ncbi.nlm.nih.gov]

The etiology of this disorder is unknown, although symptoms are exacerbated by factors that trigger innate immune responses, such as the release of cathelicidin antimicrobial [ncbi.nlm.nih.gov]

Charles: Several foods and drinks exacerbate rosacea, including: spicy foods, hot coffee or tea, and alcoholic beverages. [marieclaire.com]

Allergic Asthma

This suggests that the stress response facilitates events in the central nervous and endocrine systems, thus exacerbating asthma. [ncbi.nlm.nih.gov]

However, 47% of the allergic group patients still presented with one exacerbation in the 5th year. [ncbi.nlm.nih.gov]

After OMA cessation, 11/14 (79 %) patients showed worsening of asthma control and severe exacerbations. [ncbi.nlm.nih.gov]

Chronic Sinusitis

In case of therapy failure, antibiotics should be changed having in mind that under certain circumstances any bacteria colonizing sinus mucosa can cause acute exacerbation [ncbi.nlm.nih.gov]

However, patients may have exacerbations of acute sinusitis superimposed on the chronic disease, which may cause sinus pain, fever, and malaise. [ncbi.nlm.nih.gov]

The problem is exacerbated in the presence of antibiotic resistant strains of bacteria. [symptoma.com]

Chronic Bronchitis

Secondary outcomes included the total number of exacerbations (ie, cumulative occurrence of exacerbations during the study period) and the proportion of acute exacerbations [ncbi.nlm.nih.gov]

Logistic regression used chronic bronchitis and frequent exacerbations (≥2 exacerbations or ≥1 hospitalized exacerbations in the previous year) as response variables. [ncbi.nlm.nih.gov]

Bacteria contribute significantly to such exacerbations. [ncbi.nlm.nih.gov]

Aspirin-Induced Asthma

"Performing Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease". [en.wikipedia.org]

Aspirin exacerbated respiratory disease Other names Aspirin-induced asthma, Samter's triad, Samter's syndrome, nonsteroidal anti-inflammatory drugs-exacerbated respiratory [en.wikipedia.org]

PMID 17181095. ↑ "Salicylate-free diet in aspirin-exacerbated respiratory tract disease". [ipfs.io]

Cor Pulmonale

OBJECTIVE: To investigate the incidence of in situ thrombosis of small pulmonary arteries and arterioles during the exacerbation stage of chronic cor pulmonale. [ncbi.nlm.nih.gov]

Mortality and exacerbation were compared between COPD patients with high and low plasma BNP levels over a 3-year follow-up period. [ncbi.nlm.nih.gov]

However, pulmonary hypertension, even if mild at baseline, may worsen during exercise and sleep and during acute exacerbations of the disease. [doi.org]

Sinusitis

His initial discrete episodes of sinusitis and acute bronchitis evolved into persistent asthma of increasing severity with exacerbations requiring repeated emergency room [ncbi.nlm.nih.gov]

INTRODUCTION: Accumulating evidence supports a role for inflammation in psychiatric illness, and the onset or exacerbation of psychiatric symptoms may follow non-CNS infections [ncbi.nlm.nih.gov]

[…] bodies (root filling, augmentative dental material e.g. p CONCLUSION: If OMS is diagnosed dental focus should be treated, misplaced bodies should be removed and purulent exacerbation [ncbi.nlm.nih.gov]

Chronic Right-Sided Congestive Heart Failure

[…] fraction high-output heart failure occurs in a minority of patients cardiac output exceeds metabolic demand decompensated heart failure occurs when symptoms are worsened or exacerbated [medbullets.com]

[…] heart failure, the term “heart failure exacerbation” is used. [healio.com]

[…] failure), stage a Chf (congestive heart failure), stage b Chf (congestive heart failure), stage c Chf (congestive heart failure), stage d CHF due to valvular disease CHF exacerbation [icd9data.com]

Status Asthmaticus

CONCLUSIONS: In this cohort of children with severe asthma exacerbations, ADRβ(2) polymorphisms were associated with responses to therapy. [ncbi.nlm.nih.gov]

While most of the acute exacerbations can be managed successfully in the emergency room, few children have severe exacerbations requiring intensive care. [ncbi.nlm.nih.gov]

This report highlights the challenges in managing patients with distinct asthma exacerbation phenotypes. [ncbi.nlm.nih.gov]

Fibrinous Bronchitis

If the documentation is unclear as to whether a patient has Acute Bronchitis and an Acute Exacerbation of Asthmatic Bronchitis or just an Acute Exacerbation of Asthmatic Bronchitis [mmplusinc.com]

Acute bronchitis due to parainfluenza Acute bronchitis due to rhinovirus Acute bronchitis due to RSV Acute bronchitis due to streptococcus Acute echovirus bronchitis Acute exacerbation [icd9data.com]

Large bronchial casts appear to be rare in this century but it should be considered in patients with acute exacerbation of excessive sputa not only in patients with asthma [doi.org]

Idiopathic Pulmonary Fibrosis

Limited data suggest that patients with both acute exacerbation of IPF and suspected acute exacerbation of IPF have a similar prognosis ( 5, 36 ). [doi.org]

[…] restarted after treatment of the acute exacerbation. [ncbi.nlm.nih.gov]

There have been no reports describing acute exacerbations of idiopathic pulmonary fibrosis after particle radiotherapy for non-small cell lung cancer. [ncbi.nlm.nih.gov]

Acute Interstitial Pneumonitis

Acute exacerbation of underlying lung disease (in particular acute exacerbation of idiopathic pulmonary fibrosis ) must be considered and may explain some cases previously [msdmanuals.com]

Acute exacerbation of underlying lung disease (in particular acute exacerbation of idiopathic pulmonary fibrosis) must be considered and may explain some cases previously [msdmanuals.com]

[…] is frequently confused with other clinical entities characterized by rapidly progressive interstitial pneumonia, especially secondary acute interstitial pneumonia, acute exacerbations [ncbi.nlm.nih.gov]

Pulmonary Fibrosis

BACKGROUND: Acute exacerbations (AE) of idiopathic pulmonary fibrosis (IPF) are well recognized in the progression of this uniformly fatal disease. [ncbi.nlm.nih.gov]

[…] restarted after treatment of the acute exacerbation. [ncbi.nlm.nih.gov]

Acute Exacerbations Figure 2. Figure 2. Time to First Investigator-Reported Acute Exacerbation in INPULSIS-1 and INPULSIS-2. [doi.org]

Acute Respiratory Failure

Only seventy-nine (12%) were admitted with a COPD exacerbation, 27(4%) had acute respiratory distress syndrome (ARDS), 78 (12%) had pneumonia, 78 (12%) had sepsis, and 312 [ncbi.nlm.nih.gov]

BACKGROUND: Acute respiratory failure is a common life-threatening complication of acute onset neuromuscular diseases, and may exacerbate chronic hypoventilation in patients [ncbi.nlm.nih.gov]

BACKGROUND: Patients requiring non-invasive ventilation for acute-on-chronic respiratory failure due to chronic obstructive pulmonary disease or heart failure exacerbations [ncbi.nlm.nih.gov]

Idiopathic Interstitial Pneumonia

First, serum syndecan-4 levels in the acute exacerbation and clinically stable phases were compared. [ncbi.nlm.nih.gov]

Acute exacerbations of IIP represent periods of increased disease activity, thus we hypothesized that ECM remodeling was altered during acute exacerbations and investigated [ncbi.nlm.nih.gov]

Such episodes are termed acute exacerbation of idiopathic interstitial pneumonia. The etiology of an acute exacerbation of idiopathic interstitial pneumonia is unknown. [ncbi.nlm.nih.gov]

Cardiac Asthma

The subjects were divided into 3 groups based on symptoms of nocturnal coughing and/or wheezing in acute exacerbation of LVF. [ncbi.nlm.nih.gov]

Blepharitis

[…] that reduces or minimizes symptoms and exacerbations when possible. [health.uconn.edu]

[…] ocular manifestations of rosacea Given daily & tapered after clinical improvement is noticed usually 2-6 weeks Can be given also in intermittent courses depending on the exacerbation [specialty.mims.com]

In the last 12 months, her symptoms seemed to have exacerbated, despite the administration of a local therapy. [ncbi.nlm.nih.gov]

Asthmatic Bronchitis

He had three repeated hospitalizations, in different institutions, where he was treated for exacerbations of chronic bronchitis complicated by lower respiratory tract infections [ncbi.nlm.nih.gov]

J4522Mild intermittent asthma with status asthmaticus J4530Mild persistent asthma, uncomplicated J4531Mild persistent asthma with (acute) exacerbation J4532Mild persistent [cms.gov]

Cystic Fibrosis

This emphasizes the hypothesis that hyperglycaemia may be a factor in pulmonary exacerbations in this population. [ncbi.nlm.nih.gov]

A second primary outcome was the number of respiratory exacerbations. [ncbi.nlm.nih.gov]

However, there is currently no guidance on the use of PROMs to assess symptom burden during pulmonary exacerbations. [ncbi.nlm.nih.gov]

Jarisch Herxheimer Reaction

Manifestations include fever, chills, headache, myalgias, and exacerbation of cutaneous lesions. [medical-dictionary.thefreedictionary.com]

The Herxheimer reaction has shown an increase in inflammatory cytokines during the period of exacerbation, including tumor necrosis factor alpha, interleukin-6 and interleukin [en.wikipedia.org]

[…] hours after the first dose of antibiotics as fever, chills, rigor, hypotension, headache, tachycardia, hyperventilation, vasodilation with flushing, myalgia (muscle pain), exacerbation [en.wikipedia.org]