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11 Possible Causes for Exanthema, Fever, Systemic Autoinflammation

  • Vasculitis

    To date, several cases of systemic lupus erythematosus, Aicardi-Goutieres syndrome, familial chilblain lupus, retinal vasculopathy-cerebral leukodystrophy have been reported[ncbi.nlm.nih.gov] […] disease include fever lasting over 5 days, bilateral congestion of the conjunctiva, erythema of the lips, buccal mucosa and the tongue, cervical lymphadenopathy, polymorphous exanthema[symptoma.com] We must better appreciate the limitations of positron emission tomography in investigating a fever of unknown origin.[ncbi.nlm.nih.gov]

  • Erythema Nodosum

    Ahmet Gül, Behçet Disease, Textbook of Autoinflammation, 10.1007/978-3-319-98605-0_35, (647-665), (2019).[doi.org] […] skin syndrome, Impetigo, Boil, Carbuncle ) · Strep ( Impetigo ) · Corynebacterium ( Erythrasma ) Viral skin disease Wart · Molluscum contagiosum · Erythema infectiosum · Exanthema[wikidoc.org] Acute Q fever is asymptomatic in 60% of the patients, while the reminder may present with fever, pneumoniae, and hepatitis.[ncbi.nlm.nih.gov]

  • Cryopyrin-Associated Periodic Syndrome

    Hoffman, Autoinflammation: translating mechanism to therapy, Journal of Leukocyte Biology, 90, 1, (37-47), (2011). Keith A. Sikora and Alexei A.[doi.org] Drug Indication Risks Benefits NSAIDS Arthritis; pain, fever Adverse reactions Reduce fever, pain, arthritis Corticosteroids Fever, arthritis, serositis, urticaria, vasculitis[clinicaladvisor.com] From Wikidata Jump to navigation Jump to search syndrome Cryopyrin associated periodic fever syndrome edit Language Label Description Also known as English Cryopyrin-associated[wikidata.org]

  • Familial Mediterranean Fever

    Intrinsic apoptosis seemed irrelevant for confining synovial autoinflammation, but regulation through pyroptosis or the adaptive immune system remains possible. arthritis[pediatrics.aappublications.org] Clinical differential diagnoses encompass erysipelas, erysipelas-like rashes after joint replacements, mercury exanthemas and malignant counter-parts (e.g. erysipelas melanomatosa[oatext.com] Mutations in the MEFV gene cause familial Mediterranean fever.[ghr.nlm.nih.gov]

  • Sweet Syndrome

    French, Autoinflammation behind the curtain, British Journal of Dermatology, 178, 3, (581-582), (2018). Pedro Secchin, Maria K. Gomes, Danielle C.[doi.org] After about 5 months, he was admitted again with tachypnea and high grade fever and leukocytosis.[hindawi.com] Sweet's syndrome is a very rare dermatosis in pediatrics, of unknown pathogenesis, clinically characterized by fever, neutrophilia, raised and painful plaques on the skin[ncbi.nlm.nih.gov]

  • CINCA Syndrome

    […] autoinflammatory conditions characterized by chronic systemic inflammation due to an abnormal regulation of the innate immune system.[ncbi.nlm.nih.gov] The approach to a child with persistent fever is available .[pmmonlineindia.org] Familial Mediterranean Fever Familial Mediterranean fever (FMF) is the most common periodic fever syndrome.[my.clevelandclinic.org]

  • Pericarditis

    More recently, there has been evidence that the innate immune system and autoinflammation contribute to acute and recurrent pericarditis. [6, 7] Chronic idiopathic pericarditis[emedicine.com] […] complex with a key role in innate immunity) lead to overproduction of pro-inflammatory cytokines such as IL-1β, triggering different inflammatory symptoms, such as fever, exanthema[analesdepediatria.org] The pericarditis usually appears 7-10 days after the onset of fever and arthritis.[emedicine.com]

  • Early-Onset Sarcoidosis

    The underlying mechanisms of Blau syndrome leading to autoinflammation are still unclear, and there is currently no effective specific treatment for Blau syndrome.[readbyqxmd.com] The initial symptoms comprise a typical exanthema, with tiny round lesions that vary in colour from pale pink to tan or intense erythema.[printo.it] At age 7, fever, disseminated macular eruptions, and multinucleated giant cells in the bone marrow prompted vinblastine and prednisolone therapy.[ncbi.nlm.nih.gov]

  • Neonatal Inflammatory Skin and Bowel Disease 2

    Autoinflammation, LipoDystrophy, and Dermatosis syndrome (ALDD) ALDD is a systemic inflammatory condition starting within the first months of life, and comprising elevated[ojrd.biomedcentral.com] Roseola infantum or exanthema subitum – Human herpesvirus 6 or 7 infection – High fever for 3-4 days – Followed by seizures – Generalized rash (trunk to extremities, face[learn.pediatrics.ubc.ca] Dermographism. [13] Intermittent fevers can rise 40 C. Chills are uncommon. Fatigue and headaches are common with fevers.[autoinflammatory-search.org]

  • Ichthyosis and Male Hypogonadism

    […] autosomal dominant systemic disorder characterized by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues, including[mendelian.co] […] acute appendicitis 【急性中毒性表皮剥離(剥脱)】*epidermolysis acuta toxica[L] (略 EAT) 【急性洞炎】*acute sinusitis 【急性脳症】*acute encephalopathy 【急性副鼻腔炎】*acute paranasal sinusitis 【急性発疹】*acute exanthema[medo.jp] […] accounting keratotic lesions on on palmer creases (keratosis punctata), Follicular hyperkeratoses on shoulders, buttocks, thighs and upper arms as in case of KP and hay fever[slideshare.net]

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