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11 Possible Causes for Exanthema, High Fever, Systemic Autoinflammation

  • Erythema Nodosum

    Ahmet Gül, Behçet Disease, Textbook of Autoinflammation, 10.1007/978-3-319-98605-0_35, (647-665), (2019).[doi.org] At the initial visit, she showed high fever of 40 C, injection of the oropharynx, cervical lymphadenopathy, and red-purple cutaneous nodules, particularly on the lower limbs[ncbi.nlm.nih.gov] […] skin syndrome, Impetigo, Boil, Carbuncle ) · Strep ( Impetigo ) · Corynebacterium ( Erythrasma ) Viral skin disease Wart · Molluscum contagiosum · Erythema infectiosum · Exanthema[wikidoc.org]

  • Familial Mediterranean Fever

    Intrinsic apoptosis seemed irrelevant for confining synovial autoinflammation, but regulation through pyroptosis or the adaptive immune system remains possible. arthritis[pediatrics.aappublications.org] These episodes occurred monthly along with a high fever and elevation of the C-reactive protein (CRP) level.[ncbi.nlm.nih.gov] Clinical differential diagnoses encompass erysipelas, erysipelas-like rashes after joint replacements, mercury exanthemas and malignant counter-parts (e.g. erysipelas melanomatosa[oatext.com]

  • Sweet Syndrome

    French, Autoinflammation behind the curtain, British Journal of Dermatology, 178, 3, (581-582), (2018). Pedro Secchin, Maria K. Gomes, Danielle C.[doi.org] Sweet syndrome (acute febrile neutrophilic dermatosis) is characterized by a dramatic onset of high fever, neutrophilia and typical skin lesions.[ncbi.nlm.nih.gov] Sweet's syndrome is an uncom mon dermatosis in pediatrics, therefore, a high index of suspicion should be held in the presence of fever associated with persistent skin lesions[ncbi.nlm.nih.gov]

  • Vasculitis

    To date, several cases of systemic lupus erythematosus, Aicardi-Goutieres syndrome, familial chilblain lupus, retinal vasculopathy-cerebral leukodystrophy have been reported[ncbi.nlm.nih.gov] It can cause: asthma allergic rhinitis ( cold-like symptoms caused by allergies ) a high temperature (fever) muscle and joint pain tiredness loss of appetite and weight loss[nhs.uk] […] disease include fever lasting over 5 days, bilateral congestion of the conjunctiva, erythema of the lips, buccal mucosa and the tongue, cervical lymphadenopathy, polymorphous exanthema[symptoma.com]

  • CINCA Syndrome

    […] autoinflammatory conditions characterized by chronic systemic inflammation due to an abnormal regulation of the innate immune system.[ncbi.nlm.nih.gov] He experienced fluctuating episodes of high fever and high inflammation markers during his stay in hospital.[docksci.com] The patient’s mother and maternal grandmother also had a history of a similar urticaria-like rash without itching, associated with periodic high fever of unknown origin and[medicaljournals.se]

  • Cryopyrin-Associated Periodic Syndrome

    Hoffman, Autoinflammation: translating mechanism to therapy, Journal of Leukocyte Biology, 90, 1, (37-47), (2011). Keith A. Sikora and Alexei A.[doi.org] […] by high acute-phase reactants.[ncbi.nlm.nih.gov] He was admitted with recurrent attacks of high grade intermittent fever, associated with occipital headache, conjunctival congestion and rash for 17 years.[jpgmonline.com]

  • Pericarditis

    More recently, there has been evidence that the innate immune system and autoinflammation contribute to acute and recurrent pericarditis. [6, 7] Chronic idiopathic pericarditis[emedicine.com] Echocardiography revealed the large amount of pericardial effusion, and he was admitted to test the cause of pericardial effusion without high fever, tachycardia, and shock[ncbi.nlm.nih.gov] […] complex with a key role in innate immunity) lead to overproduction of pro-inflammatory cytokines such as IL-1β, triggering different inflammatory symptoms, such as fever, exanthema[analesdepediatria.org]

  • Ichthyosis and Male Hypogonadism

    […] autosomal dominant systemic disorder characterized by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues, including[mendelian.co] fever *hyperthermia [高体温症、過温症] 【高安動脈炎】*Takayasu arteritis 【高安病】*Takayasu's disease ( 高安幹動脈炎) (甲) 【甲介炎】*conchitis (硬) 【硬化腫】*scleroma 【硬化症】*sclerosis *[ 硬結] induration 【硬化性胃炎[medo.jp] , ANTIBODY DEFICIENCY, AND IMMUNE DYSREGULATION, PLCG2-ASSOCIATED; APLAID Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation (APLAID) is an[mendelian.co]

  • Anonychia Congenita Totalis

    […] with infantile enterocolitis (AIFEC) Immunoglobulin G4-related disease Eosinophilic sinusitis Nervous system diseases Neurodegenerative diseases Alzheimer’s disease Lewy[csirnotes.com] fever *hyperthermia [高体温症、過温症] 【高安動脈炎】*Takayasu arteritis 【高安病】*Takayasu's disease ( 高安幹動脈炎) (甲) 【甲介炎】*conchitis (硬) 【硬化腫】*scleroma 【硬化症】*sclerosis *[ 硬結] induration 【硬化性胃炎[medo.jp] […] subitum [sixth disease] B08.20 Exanthema subitum [sixth disease], unspecified B08.21 Exanthema subitum [sixth disease] due to human herpesvirus 6 B08.22 Exanthema subitum[eicd10.com]

  • Neonatal Inflammatory Skin and Bowel Disease 2

    Autoinflammation, LipoDystrophy, and Dermatosis syndrome (ALDD) ALDD is a systemic inflammatory condition starting within the first months of life, and comprising elevated[ojrd.biomedcentral.com] . [45] [46] High fevers 39 C 1-2 times/day for 2 weeks.[autoinflammatory-search.org] Roseola infantum or exanthema subitum – Human herpesvirus 6 or 7 infection – High fever for 3-4 days – Followed by seizures – Generalized rash (trunk to extremities, face[learn.pediatrics.ubc.ca]

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