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10 Possible Causes for Exanthema, Myalgia, Systemic Autoinflammation

  • Cryopyrin-Associated Periodic Syndrome

    Hoffman, Autoinflammation: translating mechanism to therapy, Journal of Leukocyte Biology, 90, 1, (37-47), (2011). Keith A. Sikora and Alexei A.[doi.org] Nine patients (69%) reported myalgia. Six patients (46%) had papilledema and a further 2 (15%) had optic disc pallor. MRI brain scan was normal in all patients.[ncbi.nlm.nih.gov] To identify the cause of disease in an adult patient presenting with recent-onset fevers, chills, urticaria, fatigue, and profound myalgia, who was found to be negative for[ncbi.nlm.nih.gov]

  • CINCA Syndrome

    […] autoinflammatory conditions characterized by chronic systemic inflammation due to an abnormal regulation of the innate immune system.[ncbi.nlm.nih.gov] Myalgia is another frequent finding in patients with FMF (reported in 20% of cases).[emedicine.medscape.com] MWS CINCA/NOMID Cold triggered Rare cold triggered No cold triggered Recurrent episodes of fever Recurrent episodes of fever Fever Urticaria Urticaria Urticaria Arthralgia/myalgia[clevelandclinicmeded.com]

  • Familial Mediterranean Fever

    Intrinsic apoptosis seemed irrelevant for confining synovial autoinflammation, but regulation through pyroptosis or the adaptive immune system remains possible. arthritis[pediatrics.aappublications.org] Clinical differential diagnoses encompass erysipelas, erysipelas-like rashes after joint replacements, mercury exanthemas and malignant counter-parts (e.g. erysipelas melanomatosa[oatext.com] Protracted febrile myalgia syndrome is a severe form of familial Mediterranean fever.[ncbi.nlm.nih.gov]

  • Vasculitis

    To date, several cases of systemic lupus erythematosus, Aicardi-Goutieres syndrome, familial chilblain lupus, retinal vasculopathy-cerebral leukodystrophy have been reported[ncbi.nlm.nih.gov] […] disease include fever lasting over 5 days, bilateral congestion of the conjunctiva, erythema of the lips, buccal mucosa and the tongue, cervical lymphadenopathy, polymorphous exanthema[symptoma.com] Clinical presentation ranges from arthralgia, myalgia, petechiae, or rash to single or multiorgan involvement.[ncbi.nlm.nih.gov]

  • Sweet Syndrome

    French, Autoinflammation behind the curtain, British Journal of Dermatology, 178, 3, (581-582), (2018). Pedro Secchin, Maria K. Gomes, Danielle C.[doi.org] Up to 62% of cases [ 3 , 4 ] have musculo‐skeletal manifestations including myalgia, arthralgia and arthritis.[rheumatology.oxfordjournals.org] Systemic side effects of PCV13 include chills, fever, headache, vomiting, fatigue, arthralgia, myalgias, decreased appetite, and diarrhea, whereas its cutaneous adverse reactions[medical-dictionary.thefreedictionary.com]

  • Pericarditis

    More recently, there has been evidence that the innate immune system and autoinflammation contribute to acute and recurrent pericarditis. [6, 7] Chronic idiopathic pericarditis[emedicine.com] […] complex with a key role in innate immunity) lead to overproduction of pro-inflammatory cytokines such as IL-1β, triggering different inflammatory symptoms, such as fever, exanthema[analesdepediatria.org] An early set of symptoms - a prodrome - of fever (usually 39 C), malaise and myalgia and/or arthralgia is common.[escardio.org]

  • Ichthyosis and Male Hypogonadism

    […] autosomal dominant systemic disorder characterized by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues, including[mendelian.co] […] acute appendicitis 【急性中毒性表皮剥離(剥脱)】*epidermolysis acuta toxica[L] (略 EAT) 【急性洞炎】*acute sinusitis 【急性脳症】*acute encephalopathy 【急性副鼻腔炎】*acute paranasal sinusitis 【急性発疹】*acute exanthema[medo.jp] , ANTIBODY DEFICIENCY, AND IMMUNE DYSREGULATION, PLCG2-ASSOCIATED; APLAID Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation (APLAID) is an[mendelian.co]

  • Anonychia Congenita Totalis

    […] with infantile enterocolitis (AIFEC) Immunoglobulin G4-related disease Eosinophilic sinusitis Nervous system diseases Neurodegenerative diseases Alzheimer’s disease Lewy[csirnotes.com] […] subitum [sixth disease] B08.20 Exanthema subitum [sixth disease], unspecified B08.21 Exanthema subitum [sixth disease] due to human herpesvirus 6 B08.22 Exanthema subitum[eicd10.com] Type I diabetes mellitus Absent eyebrow Autoimmune hemolytic anemia Myositis Thrombocytosis Severe combined immunodeficiency Lymphopenia Pain Fever Arthritis Arthralgia Myalgia[mendelian.co]

  • Neonatal Inflammatory Skin and Bowel Disease 2

    Autoinflammation, LipoDystrophy, and Dermatosis syndrome (ALDD) ALDD is a systemic inflammatory condition starting within the first months of life, and comprising elevated[ojrd.biomedcentral.com] Roseola infantum or exanthema subitum – Human herpesvirus 6 or 7 infection – High fever for 3-4 days – Followed by seizures – Generalized rash (trunk to extremities, face[learn.pediatrics.ubc.ca] Fevers 39–40 C myalgia, headaches with flares. Sensorineural hearing loss.[autoinflammatory-search.org]

  • Early-Onset Sarcoidosis

    The underlying mechanisms of Blau syndrome leading to autoinflammation are still unclear, and there is currently no effective specific treatment for Blau syndrome.[readbyqxmd.com] The initial symptoms comprise a typical exanthema, with tiny round lesions that vary in colour from pale pink to tan or intense erythema.[printo.it] […] organ involvement, however non specific severe symptoms most commonly reported that reduce the quality of life significantly are: profound fatigue, malaise, arthralgia, myalgia[sa-uk.org]

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