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206 Possible Causes for Exanthema, T Cell Activation Increased

  • Acne Vulgaris

    PPARα increases activity of activator protein 1 (AP-1) and NF-κB, thereby leading to the recruitment of inflammatory T cells.[en.wikipedia.org] Esophagitis ( ) ( ) Phototoxicity ( ) ( ) Hyperpigmentation Drug-induced lupus erythematosus Cholestatic hepatitis, pancreatitis, pseudomembranous colitis ( ) ( ) (( )) Exanthema[ncbi.nlm.nih.gov] LTB4 promotes skin inflammation by acting on the peroxisome proliferator-activated receptor alpha (PPARα) protein.[en.wikipedia.org]

  • Dermatitis

    These early effects lead to increased histamine release from IgE-activated mast cells and elevated activity of the T-helper cell–mediated immune system.[emedicine.com] […] depression, increased sebum levels, and an activation of the alternative complement pathway.[emedicine.medscape.com] Topically applied nanoEGCG elicited a significant ( p T cells), and angiogenesis (CD31).[ncbi.nlm.nih.gov]

  • Contact Dermatitis

    Investigations of allergic contact dermatitis suggest that certain allergens may also activate particular T cell signatures such as TH 2-dominant responses to fragrance and[ncbi.nlm.nih.gov] They had eczema of the hands, and forearms or face, and 1 patient, who previously had exanthema caused by flucloxacillin, also developed a generalized rash following airborne[ncbi.nlm.nih.gov] Atopic dermatitis is characterized by skin barrier abnormalities and immune dysregulation with increased TH 2 signaling playing a central role.[ncbi.nlm.nih.gov]

  • Food Allergy

    Memory T cells are increased in frequency and have distinct activation requirements and cell-surface proteins that distinguish them from armed effector T cells 10-25.[ncbi.nlm.nih.gov] […] affinity of antibody owing to somatic hypermutation and selection by antigen in germinal centers 10-24 Memory T cells are increased in frequency and have distinct activation[ncbi.nlm.nih.gov] Transcription of the HIV provirus depends on host cell transcription factors induced upon the activation of infected T cells 11-22.[ncbi.nlm.nih.gov]

  • Atopic Dermatitis

    These early effects lead to increased histamine release from IgE-activated mast cells and elevated activity of the T-helper cell–mediated immune system.[emedicine.com] These data suggest that CD86 expression on LCs plays an important role as co-stimulatory molecules for T cell activation and may account for the increased Th2 responses that[omicsonline.org] The increased release of vascular mediators (eg, bradykinin, histamine, slow-reacting substance of anaphylaxis [SRS-A]) induces vasodilation, edema, and urticaria, which in[emedicine.com]

  • Infectious Mononucleosis

    The persistent activation of T cells in our patient may have increased the likelihood of development of uncontrolled T-cell lymphoproliferative disease.[dx.doi.org] Amoxicillin-induced exanthema in young adults with infectious mononucleosis: Demonstration of drug-specific lymphocyte reactivity. Br J Dermatol 2002 ; 147: 1166 – 70.[dx.doi.org] Timár L, Baló-Banga JM, Budai J (1987) [Infectious mononucleosis and drug exanthema].Orv Hetil 128: 1871-1874.[omicsonline.org]

  • Herpes Zoster

    Vaccination with an attenuated form of VZV activates specific T cell production, therefore avoiding viral reactivation ( Arvin 2005 ).[dx.doi.org] The exanthema crusts over within 7-10 days, mostly healing completely, in severe blistering, however, scars and skin discoloring might remain. 5 Diagnosis visual examination[flexikon.doccheck.com] ., which is often subsequently clearer, once neuritis and vesicular exanthema –common HZ symptoms– develop.[revistanefrologia.com]

  • Psoriasis

    The psoriatic lesions are linked with increased T-cell activity beneath the underlying skin area.[symptoma.com] Viral exanthema should also be considered. Especially in patients with palmar and plantar lesions, serologic analysis should be performed to exclude secondary syphilis.[emedicine.com] Psoriatic lesions are associated with increased activity of T cells in the underlying skin. Psoriasis is related to excess T-cell activity.[emedicine.com]

  • Pityriasis Circinata

    T-cell mediated immunity in the development of the condition.[emedicine.com] Pityriasis Rosea (PR) History:(i) Close contacts with similar eruptions: Mostly uncommon because most cases of PR are sporadic(ii) Medication intake: Could cause a similar exanthema[dailyrounds.org] Current evidence indicates that PR is a type of viral exanthema and the etiology may be possibly linked to human herpes viruses HHV6 and HHV7 [3].[odermatol.com]

  • Drug Hypersensitivity

    Areas covered: This article reviews the pathways of T-cell activation by drugs and how the ever increasing number of associations between expression of HLA alleles and susceptibility[ncbi.nlm.nih.gov] Since then, many different types of exanthemas from the mild macular-papular forms to the severe life-threatening bullous exanthemas such as toxic epidermal necrolysis have[ncbi.nlm.nih.gov] In the sulfamethoxazole model of p-i TCR, responsive T cells likely require costimulation for full T cell activation.[ncbi.nlm.nih.gov]

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