Excessive Wrinkled Skin: Causes & Reasons

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Possible Causes for Excessive Wrinkled Skin

Brittle Cornea Syndrome Type 1

wrinkled skin of palms and soles). [xpertdox.com]

[…] increased size of the skull), myopia (closed sightedness), epicanthus (eye folds), disproportionate tall stature, red hair, spondylolisthesis, and palmoplantar cutis laxa (excessive [xpertdox.com]

[…] fractures, mitral valve prolapse, neonatal hypotonia, narrowing of pulmonary valve, retinal detachment, sclerocornea, scoliosis (abnormal curving of spine), atypical scarring of skin [xpertdox.com]

Ehlers-Danlos Syndrome Periodontitis Type 1

wrinkled skin of palms and soles Increased wrinkles of palms and soles Wrinkled palms and soles Wrinkled skin of hands and feet [ more ] 0007517 Poor wound healing 0001058 [rarediseases.info.nih.gov]

Excessive wrinkling and thinness of skin over hands and feet produces an acrogeric or an old looking appearance. [5], [6] Joint hypermobility is a dominant manifestation particularly [jdrr.org]

Redundant, almost lax skin, with excessive skin folds at wrists and ankles. Increased palmar wrinkling. [patient.info]

Ehlers-Danlos Syndrome Kyphoscoliotic Type 1

wrinkled skin of palms and soles Increased wrinkles of palms and soles Wrinkled palms and soles Wrinkled skin of hands and feet [ more ] 0007517 Pes planus Flat feet Flat [rarediseases.info.nih.gov]

Redundant, almost lax skin, with excessive skin folds at wrists and ankles. Increased palmar wrinkling. [patient.info]

Loosejointedness [ more ] 0001388 Molluscoid pseudotumors 0000993 Motor delay 0001270 Muscular hypotonia Low or weak muscle tone 0001252 Osteoporosis 0000939 Palmoplantar cutis laxa Excessive [rarediseases.info.nih.gov]

Autosomal Recessive Cutis Laxa Type 1A

wrinkled skin Minicore myopathy Left ventricular noncompaction Mitochondrial depletion Dilatation Proptosis Skeletal dysplasia Camptodactyly Platyspondyly Joint hypermobility [mendelian.co]

Definition A form of cutis laxa, a disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with [uniprot.org]

UniProtKB/Swiss-Prot : 73 Cutis laxa, autosomal recessive, 2B: A disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, [malacards.org]

Dermatosparaxis

[…] with presence of excessive skin folds at the ankles and wrists Increase in palmar wrinkling Excessive bruisability with heightened risk of subcutaneous haemorrhage and hematomas [xpertdox.com]

with excessive skin folds at the wrists and ankles Increased palmar wrinkling Severe bruisability with a risk of subcutaneous hematomas and haemorrhage Umbilical hernia [rarediseases.info.nih.gov]

Other signs and symptoms include Dysphasia, Echolalia, Esophagitis, Excessive wrinkled skin, Aphasia, Avascular necrosis of the capital femoral epiphysis, Coxa valga, Coxa [xpertdox.com]

Odontomatosis - Aortae Esophagus Stenosis Syndrome

[…] morphology Limited elbow movement Excessive wrinkled skin Subvalvular aortic stenosis Hyposmia Aplasia/Hypoplasia of the abdominal wall musculature Severe sensorineural hearing [mendelian.co]

wrinkling Fragile nails Hydrocephalus Abnormal hair quantity Abnormal localization of kidney Abnormal pulmonary valve morphology Multiple lentigines Abnormal mitral valve [mendelian.co]

Absent eyebrow Short palm Basal cell carcinoma Mitral valve calcification Congenital cataract Emphysema Intracranial hemorrhage Papillary renal cell carcinoma Premature skin [mendelian.co]

Storm Syndrome

prematurely aged appearance excessive wrinkling of palmar skin taut skin over hands and face no scleroderma-type changes Eyes: no cataracts G I: intestinal fat malabsorption [malacards.org]

wrinkling of palmar skin 33 HP:0007605 7 early progressive calcific cardiac valvular disease 33 HP:0006694 8 myxomatous mitral valve degeneration 33 HP:0004764 9 polyarticular [malacards.org]

[…] calcification 33 HP:0004382 2 aortic valve stenosis 33 HP:0001650 3 aortic valve calcification 33 HP:0004380 4 mitral stenosis 33 HP:0001718 5 fat malabsorption 33 HP:0002630 6 excessive [malacards.org]

Ehlers-Danlos Syndrome Type Beasley-Cohen

Nails Hair Skin: excessive skin wrinkling on dorsum of hands and fingers skin hyperelasticity cigarette paper scarring Neurologic Central Nervous System: mental retardation [malacards.org]

skin wrinkling on dorsum of hands and fingers ; Genu recurvatum ; Hearing impairment ; Hip dislocation ; Hyperextensible skin ; Inguinal hernia ; Intellectual disability [m.mousephenotype.org]

skin wrinkling on dorsum of hands and fingers Hyperextensible skin Abnormality of the musculoskeletal system Cigarette-paper scars Decreased muscle mass Genu recurvatum Hip [ncbi.nlm.nih.gov]

Autosomal Recessive Cutis Laxa Type 2

UniProtKB/Swiss-Prot : 72 Cutis laxa, autosomal recessive, 2D: A form of cutis laxa, a disorder characterized by an excessive congenital skin wrinkling, a large fontanelle [malacards.org]

Both neonates had excessive skinfolds in the neck and axial regions, and wrinkled skin of the hands and feet. [nature.com]

wrinkled skin and increased joint laxity. [nature.com]

Eyebrow Duplication - Syndactyly Syndrome

wrinkling congenital fibromata of lips Skin: excessively stretchable skin of face and chest Clinical features from OMIM: 227210 Drugs & Therapeutics for Eyebrows, Duplication [malacards.org]

bilateral mild syndactyly involving - hyperelasticity of the skin - excessive wrinkling of periorbital skin Urogenital - Cryptorchidism Full duplication of the eyebrows [docslide.com.br]

excessive wrinkling of periorbital skin and other mi- nor congenital malformations. [myslide.es]

Autosomal Recessive Cutis Laxa Type 2A

Definition A disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral [uniprot.org]

Both neonates had excessive skinfolds in the neck and axial regions, and wrinkled skin of the hands and feet. [nature.com]

wrinkled skin and increased joint laxity. [nature.com]

Bird-Headed Dwarfism Type Montreal

wrinkling of palmar skin 32 HP:0007605 36 abnormally large globe 32 HP:0001090 37 abnormal palate morphology 32 hallmark (90%) HP:0000174 [malacards.org]

wrinkling of palmar skin Redundant, wrinkled skin of palms 0007605 Narrow face Decreased breadth of face Decreased width of face [ more ] 0000275 Retrognathia Receding chin [rarediseases.info.nih.gov]

[…] the palate 59 Very frequent (99-80%) 32 brain very small 32 HP:0001322 33 alopecia of scalp 32 hallmark (90%) HP:0002293 34 scalp hair loss 59 Very frequent (99-80%) 35 excessive [malacards.org]

Chromosome 6q11-q14 Deletion Syndrome

wrinkled skin Avascular necrosis of the capital femoral epiphysis Abnormality of subcutaneous fat tissue Feeding difficulties Tics Fatigue Dilatation Respiratory failure [mendelian.co]

Coxa vara Rickets Dysphasia Prolonged bleeding time Aphasia Osteomalacia Aortic rupture Abnormal joint morphology Dyspnea Hiatus hernia Echolalia Esophagitis Femoral hernia Excessive [mendelian.co]

Prematurely aged appearance Aortic root aneurysm Aortic dissection Heart murmur Pulmonary artery stenosis Uterine prolapse Skin rash Scarring Frontal bossing Hip dysplasia Thin skin [mendelian.co]

Congenital Aural Atresia

wrinkled skin Show HP:0007495 Prematurely aged appearance Show HP:0007565 Multiple cafe-au-lait spots Show HP:0007776 Partial absence of lower eyelashes Show HP:0007957 Variable [manteia.igbmc.fr]

[…] nasal morphology Show HP:0005280 Depressed nasal root and bridge Show HP:0005338 Sparse lateral eyebrows Show HP:0006709 Aplasia/Hypoplasia of the nipples Show HP:0007392 Excessive [manteia.igbmc.fr]

Oculorenocerebellar Syndrome

wrinkled skin Redundant neck skin Generalized joint laxity Subretinal pigment epithelium hemorrhage Growth delay Psychosis Anxiety Bone cyst Prominent nose Epididymal cyst [mendelian.co]

[…] ganglia lesion Abnormal apolipoprotein level Abnormal isoelectric focusing of serum transferrin Prominent nasolabial fold Sparse eyelashes Inguinal freckling Thick hair Excessive [mendelian.co]

Arthrogryposis, Perthes Disease and Upward Gaze Palsy

wrinkled skin Optic nerve dysplasia Patchy alopecia Colitis Frontal balding Multiple lentigines Sparse or absent eyelashes Hyperextensibility of the finger joints Abnormality [mendelian.co]

[…] hyperpigmentation Long palpebral fissure Absent eyebrow Biparietal narrowing Sparse eyebrow Open bite Hypoplasia of the zygomatic bone Woolly hair Generalized ichthyosis Excessive [mendelian.co]

Acrogeria

Frequently present symptoms in 30-79% of the cases: Convex nasal ridge Excessive wrinkled skin Intellectual disability Micrognathia Scoliosis Short foot Small hand Telangiectasia [dovemed.com]

Two siblings, a sister and a brother aged 20 years and 24 years respectively, reported to our department with complaints of premature graying of hair and excessive wrinkling [ijdvl.com]

wrinkling of skin over the face, hands and feet. [bioline.org.br]

Ehlers-Danlos Syndrome Type 4

wrinkled skin 0007392 Gingival overgrowth Gum enlargement 0000212 Gingivitis Inflamed gums Red and swollen gums [ more ] 0000230 Hemoptysis Coughing up blood 0002105 High [rarediseases.info.nih.gov]

[…] refer to excessive wrinkling and thinness of the skin over hands and feet, which may produce an elderly appearance. [path.upmc.edu]

Excessive wrinkling and thinness of skin over hands and feet produces an acrogeric or an old looking appearance. [5], [6] Joint hypermobility is a dominant manifestation particularly [jdrr.org]

Nicolaides-Baraitser Syndrome

wrinkled skin 0007392 Highly arched eyebrow Arched eyebrows Broad, arched eyebrows High, rounded eyebrows High-arched eyebrows Thick, flared eyebrows [ more ] 0002553 Long [rarediseases.info.nih.gov]

wrinkled skin 58 31 frequent (33%) Frequent (79-30%) HP:0007392 40 broad distal phalanx of finger 58 31 frequent (33%) Frequent (79-30%) HP:0009836 41 generalized non-motor [malacards.org]

Clubbing of toes Clubbing of feet 0100760 Cryptorchidism Undescended testes Undescended testis [ more ] 0000028 Curly eyelashes 0007665 Eczema 0000964 Epileptic spasms 0011097 Excessive [rarediseases.info.nih.gov]

Amelogenesis Imperfecta Type 2A5

wrinkled skin Ascending tubular aorta aneurysm Arterial stenosis Bladder diverticulum Abnormality of hair texture Aplasia/Hypoplasia of the earlobes Abnormal pupil morphology [mendelian.co]

[…] clinodactyly Abnormality of digit Radial deviation of the 3rd finger Mitral valve prolapse Episodic fever Reduced consciousness/confusion Periorbital edema Pneumothorax Excessive [mendelian.co]

SHORT Syndrome

wrinkled skin 0007392 Glaucoma 0000501 Hypotrichosis Sparse hair since birth 0001006 Insulin resistance Body fails to respond to insulin 0000855 Lipodystrophy Inability to [rarediseases.info.nih.gov]

0000615 Abnormality of dental enamel Abnormal tooth enamel Enamel abnormalities Enamel abnormality [ more ] 0000682 Alopecia Hair loss 0001596 Diabetes mellitus 0000819 Excessive [rarediseases.info.nih.gov]

Camptodactyly Syndrome Guadalajara Type 1

wrinkled skin Hallucinations Hypogonadotrophic hypogonadism Flat occiput Purpura Hyperlipidemia Breast hypoplasia High-frequency hearing impairment Premature ovarian insufficiency [mendelian.co]

Aplasia/Hypoplasia of the eyebrow Absent nipple Conical tooth Abnormal nasal morphology Dehydration Hypergonadotropic hypogonadism Overbite Intervertebral disc degeneration Excessive [mendelian.co]

Marfanoid Habitus with Situs Inversus

NAILS, HAIR: [Skin]; Soft thin skin; Hyperextensible skin; Moderate scarring; Easy bruisability; Molluscoid pseudotumors; Excessive wrinkled skin (palms and soles) MUSCLE [findzebra.com]

[…] laxity; Osteoporosis; Recurrent joint dislocations; [Spine]; Congenital scoliosis, progressive; Kyphosis; [Hands]; Arachnodactyly; [Feet]; Pes planus; Talipes equinovarus SKIN [findzebra.com]

Wrinkles

FEELING STRESSED OR TIRED When you’re stressed or tired, your body releases excess cortisol, a hormone which is known to cause premature skin ageing and wrinkles. [nivea.com.au]

"Over time, excess motion, gravity and skin laxity will cause fine lines and wrinkles to form," Dr. Frank notes. [townandcountrymag.com]

On one side YOU would be forgiven for thinking that sleeping in excess would only be good for your skin. [thesun.co.uk]

Facioauriculoradial Dysplasia

wrinkled skin Broad distal phalanx of finger Eclabion Broad columella Prominent proximal interphalangeal joints Enlarged joints Broad philtrum Abnormality of the testis Abnormal [mendelian.co]

Cardiomegaly Neurogenic bladder Tracheal stenosis Narrow nasal bridge Wide nasal base Prominent interphalangeal joints Curly eyelashes Clubbing of toes Thick nasal alae Excessive [mendelian.co]

Camptodactyly Syndrome Type Guadalajara III

Excessive wrinkled skin Thick hair Psychomotor deterioration Prominent nasolabial fold Prominent veins on trunk Abnormal subcutaneous fat tissue distribution Abnormality [mendelian.co]

[…] fetal movement Abnormality of hair texture Cataract Cleft upper lip Thick cerebral cortex Delayed closure of the anterior fontanelle Generalized joint laxity Redundant neck skin [mendelian.co]

Cutis Laxa

Definition A disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral [uniprot.org]

All forms of CL share the symptom of excess, loose and wrinkled skin. Most forms of CL are not associated with an augmented vulnerability, though. [symptoma.com]

Both neonates had excessive skinfolds in the neck and axial regions, and wrinkled skin of the hands and feet. [nature.com]

Autosomal Dominant Aplasia and Myelodysplasia

wrinkled skin Microcephaly Gastrointestinal hemorrhage Bruising susceptibility Ptosis Stroke Carious teeth Anorexia Sporadic Premature loss of teeth Nail dystrophy Cerebellar [mendelian.co]

Immunodeficiency Tics Hypertension Hepatomegaly Weight loss Neutropenia Alopecia Seizures Rare Symptoms - Less than 30% cases Vertigo Leukocytosis Oral leukoplakia Somatic mutation Excessive [mendelian.co]

Ehlers-Danlos Syndrom Classic Type 2

Redundant, almost lax skin, with excessive skin folds at wrists and ankles. Increased palmar wrinkling. [patient.info]

[…] dislocation Dislocated hip since birth 0001374 Cystocele Bladder hernia Dropped bladder [ more ] 0100645 Deeply set eye Deep set eye Deep-set eyes Sunken eye [ more ] 0000490 Excessive [rarediseases.info.nih.gov]

Peeling Skin Syndrome Type 3

[…] flaking skin peeling skin scaly skin [ more ] 0040189 5%-29% of people have these symptoms Excessive wrinkling of palmar skin Redundant, wrinkled skin of palms 0007605 Hyperpigmentation [rarediseases.info.nih.gov]

[…] more ] 0008066 Allergy 0012393 Eczema 0000964 Erythema 0010783 High hypermetropia Severe farsightedness Severe long-sightedness [ more ] 0008499 Ichthyosis 0008064 Scaling skin [rarediseases.info.nih.gov]