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1,807 Possible Causes for Exertional Dyspnea, Mutation in the Hereditary Hemochromatosis Gene, Nocturnal Paroxysmal Dyspnea

  • Heart Failure

    Here we present an 80-year-old Asian woman complaining of progressive exertional dyspnea.[ncbi.nlm.nih.gov] Major criteria: · Paroxysmal nocturnal dyspnea · Neck vein distention · Rales · Radiographic cardiomegaly (increasing heart size on chest radiography) · Acute pulmonary edema[web.archive.org] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org]

  • Pulmonary Edema

    High altitude pulmonary edema (HAPE) is a form of high altitude illness characterized by cough, dyspnea upon exertion progressing to dyspnea at rest and eventual death, seen[ncbi.nlm.nih.gov] […] or comorbid paroxysmal nocturnal dyspnea and orthopnea are present, even in patients with preeclampsia.[ncbi.nlm.nih.gov] Shortly after, she started to have exertional dyspnea, which progressed gradually from New York Heart Association (NYHA) classes II–IV over the course of 4 days.[edm.bioscientifica.com]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Cardiomyopathy

    dyspnea , a feeling of pressure in the chest Later stages Progressive left heart failure and right heart failure Relative mitral valve regurgitation Diagnostics Patient history[amboss.com] Symptoms: Patients with cardiomyopathy will typically present with dyspnea, orthopnea, paroxysmal nocturnal dyspnea, bilateral edema, and fatigue.[symptoma.com] dyspnea, angina, syncope, sudden death Systolic murmur mitral regurgitation murmur, S4 Bifid carotid pulse with a brisk upstroke and rapid downstroke Exertional dyspnea and[merckmanuals.com]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Congestive Heart Failure

    A 78-year-old woman presented with mild exertional dyspnea three weeks after starting osimertinib for the treatment of epidermal growth factor receptor (EGFR) T790M-positive[ncbi.nlm.nih.gov] Features due to left heart failure: Dyspnea, orthopnea and paroxysmal nocturnal dyspnea: These symptoms develop due to congestion of the lungs.[symptoma.com] The actuarial survival rates of persons who are homozygous for the mutation of the hemochromatosis gene C282Y have been reported to be 95%, 93%, and 66%, at 5, 10, and 20[doi.org]

  • High Output Heart Failure

    A 51-yr-old man presented exertional dyspnea as a consequence of iliocaval fistula combined with paradoxical pulmonary embolism and high-output heart failure.[ncbi.nlm.nih.gov] Attacks of breathlessness severe enough to wake the patient frequently occur during sleep ( paroxysmal nocturnal dyspnea ).[medical-dictionary.thefreedictionary.com] A 64-year-old woman was admitted with systemic edema and exertional dyspnea.[ncbi.nlm.nih.gov]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Coronary Atherosclerosis

    Patients who have “ischemic equivalents,” such as dyspnea or arm pain with exertion, are included in the latter group.[circ.ahajournals.org] Substernal chest pressure upon physical exertion with radiation to the medial portion of the left arm or left jaw is the classic description.[healio.com] […] myocardial ischemia, that pressure can be transmitted backward to the pulmonary veins and into the pulmonary vasculature, causing transient pulmonary edema that results in dyspnea[healio.com]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Aortic Valve Stenosis

    ., when it first becomes symptomatic ( dyspnea on exertion, angina pectoris, or syncope ).[amboss.com] Other symptoms associated with AS are related to cardiac failure, such as paroxysmal nocturnal dyspnea, orthopnea, and dyspnea on exertion.[symptoma.com] The patient also presented dyspnea on minimal exertion, orthopnea, paroxysmal nocturnal dyspnea and edema of lower limbs. The patient denied fever.[web.archive.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Dilated Cardiomyopathy

    Left ventricular dysfunction causes exertional dyspnea and fatigue due to elevated left ventricular diastolic pressure and low cardiac output.[merckmanuals.com] The following are the symptoms with which a patient may present: fatigue, orthopnea, dyspnea on exertion, paroxysmal nocturnal dyspnea, increasing edema, weight gain, or an[symptoma.com] At presentation she had dyspnea at rest, orthopnea and paroxysmal nocturnal dyspnea.[doi.org]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Aortic Valve Insufficiency

    dyspnea Chest pain (angina) Dizziness Syncope Complications Left ventricular volume overload with left ventricular dilatation Decreased left ventricular systolic function[echocardiology.org] As the disease progresses, orthopnea and paroxysmal nocturnal dyspnea start to occur. Angina is predominantly nocturnal in these patients.[symptoma.com] dyspnea (common) Orthopnea (common) Paroxysmal nocturnal dyspnea (common) Angina pectoris (less common) Abdominal discomfort (less common) Syncope (rare) Nocturnal angina[emedicine.medscape.com]

    Missing: Mutation in the Hereditary Hemochromatosis Gene
  • Hemochromatosis

    A woman in her 70s was admitted with progressive dyspnea on exertion.[jsum.or.jp] Hereditary hemochromatosis can be divided into HFE- and non-HFE-related based on genetic mutations in different genes.[ncbi.nlm.nih.gov] Gene mutations that cause hemochromatosis A gene called HFE is most often the cause of hereditary hemochromatosis. You inherit one HFE gene from each of your parents.[mayoclinic.com]

    Missing: Nocturnal Paroxysmal Dyspnea