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27 Possible Causes for Exertional Dyspnea, Polychromasia in Peripheral Blood Smear

  • Autoimmune Hemolytic Anemia

    The disease is characterized by symptoms due to the anemia including fatigue, exertional dyspnea, and, more rarely, jaundice and dark urine in case of severe hemolysis.[orpha.net] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[jahjournal.org] AIHA is characterized by hemolytic anemia, which is most often revealed by an unusual weakness and fatigue with tachycardia and exertional dyspnea, and also in some cases[orpha.net]

  • Paroxysmal Cold Hemoglobinuria

    These symptoms may include fatigue, difficulty breathing upon exertion (dyspnea) and abnormal or extreme paleness of the skin (pallor).[rarediseases.org] Tests include complete blood count (CBC) and peripheral smear.[emedicine.com] Clinical manifestations may include the following: Anemia – paleness, fatigue, exertional tiredness Tachycardia, dyspnea, angina, and weakness if anemia Abdominal pain due[medcaretips.com]

  • Hemolytic Anemia

    Patients with AIHA usually present with acute onset shortness of breath, dyspnea on exertion, palpitations, dizziness, progressive weakness or tiredness.[cancertherapyadvisor.com] Mean corpuscular volume was 96 fl, and the reticulocyte count was 11%, with marked polychromasia on peripheral smear.[care.diabetesjournals.org] The peripheral blood smear post-splenectomy often shows crenated or spiculated spherocytes and marked polychromasia.[clinicaladvisor.com]

  • Chronic Acquired Pure Red Cell Aplasia

    dyspnea, chest pain on exertion, fatigue and lethargy are major symptoms of severe anemia.[explainmedicine.com] blood smear showed anisocytosis, poikilocytosis, polychromasia and leukocytosis.[ijmstrust.in] , exertional intolerance.[explainmedicine.com]

  • Congenital Dyserythropoietic Anemia

    […] on exertion, palpitations, angina and intermittent claudication, headache, vertigo, light-headedness, visual disturbances, drowsiness, anorexia, nausea, bowel disturbances[clinicalgate.com] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[ncbi.nlm.nih.gov] Autoimmune disorders Pernicious anemia Rheumatoid arthritis Bleeding disorders Hemophilia von Willebrand disease Symptoms of anemia include lassitude, easy fatigability, dyspnea[clinicalgate.com]

  • Acquired Sideroblastic Anemia

    Microcytic anemia ( MCV 80 fL ) Macrocytic anemia ( MCV 100 fL ) Normocytic anemia ( MCV 80–100 fL ) References: [2] [1] [3] Clinical features Exertional dyspnea and fatigue[amboss.com] Blood Smear Peripheral blood smear images .[imagebank.hematology.org] dyspnea Headache, vertigo Pale or yellow skin Some forms of CSA are associated with other symptoms or signs outside the blood system.[danafarberbostonchildrens.org]

  • Acquired Hemolytic Anemia

    The disease is characterized by symptoms due to the anemia including fatigue, exertional dyspnea, and, more rarely, jaundice and dark urine in case of severe hemolysis.[orpha.net] blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[amboss.com] Clinical manifestations may include the following: Anemia – paleness, fatigue, exertional tiredness Tachycardia, dyspnea, angina, and weakness if anemia Abdominal pain due[medcaretips.com]

  • Acquired Thrombotic Thrombocytopenic Purpura

    Presenting symptoms included fevers, sore throat and productive cough with progressive weakness, dyspnea on exertion, hemoptysis and dark urine.[ncbi.nlm.nih.gov] Blood Smear (see Peripheral Blood Smear, [[Peripheral Blood Smear]]) Findings Polychromasia : due to reticulocytosis Schistocytes/Helmet Cells/Triangular Cells : RBC fragments[mdnxs.com] Number is affected by the duration of disease and quality of peripheral blood smear There is no threshold number of schistocytes below which TTP can be excluded Microspherocytes[mdnxs.com]

  • Cold Agglutinin Disease

    Clinical findings at time of presentation include anemia, acrocyanosis, fatigue, weakness, and dyspnea on exertion.[blog.medicalalgorithms.com] Reticulocytes and Spherocytes The results of the reticulocyte count are usually increased in patients with cold agglutinin disease, with polychromasia in the peripheral blood[web.archive.org] blood smear : spherocytes , polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[amboss.com]

  • Microangiopathic Hemolytic Anemia

    A 36-year-old woman came to our hospital with lower back pain and progressive exertional dyspnea for 8 weeks.[ncbi.nlm.nih.gov] Hemosiderinuria is seen in chronic intravascular hemolysis. 4) Examination of blood smear: Careful examination of peripheral blood smear by an experienced person provides[bioline.org.br] The peripheral blood smear revealed polychromasia, poikilocytosis, and many schistocytes. Bone marrow biopsy disclosed metastatic carcinoma.[ncbi.nlm.nih.gov]

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