Extraocular Muscle Weakness: Causes & Reasons

Possible Causes for Extraocular Muscle Weakness

[…] girdle muscle weakness Extraocular muscle weakness Peripheral neuropathy Migraine headaches Seizures Stroke Diabetes mellitus Cardiac arrhythmias Acid maltase deficiency or [clevelandclinicmeded.com]

[…] of the extraocular muscles is the initial clinical finding.. [brainscape.com]

Patients exhibit exercise intolerance, proximal or extraocular muscle weakness, myoclonus, salt craving, ataxia, sensorineural hearing loss, or peripheral neuropathy. [rheumaknowledgy.com]

Oculo-Pharyngo-Distal Myopathy

When other cranial nerve muscles are weak, causing ptosis or extraocular muscle weakness, the most important disorders to consider include neuromuscular junction disorders [accessmedicine.mhmedical.com]

muscle weakness, and proximal limb weakness. [webeye.ophth.uiowa.edu]

AChR AB, acetylcholine receptor antibody; CPT, carnitine palmitoyltransferase; EOMs, extraocular muscles; MG, myasthenia gravis; PP, periodic paralysis. [accessmedicine.mhmedical.com]

Hereditary Proximal Myopathy with Early Respiratory Failure

Locations: Heart, Slow muscles, Extraocular (EO) muscles; GI tract; Renal Myosin disorders Clinical Onset age: 4 to 23 years Weakness Distal: Occasionally also proximal Legs [neuromuscular.wustl.edu]

Pregnancy- and labor-related complications Eyelid ptosis without extraocular muscle weakness Oculopharyngeal muscular dystrophy Relatively rare Rarely presents with distal [clevelandclinicmeded.com]

Autosomal Dominant Myoglobinuria

The clinical phenotype associated with a later childhood onset can include abnormal muscle fatigue, delayed motor milestones, ptosis, and extraocular muscle weakness. [mayocliniclabs.com]

Systemic Features: The weakness in extraocular and levator muscles is sometimes associated with more generalized myopathy of a variable degree. [disorders.eyes.arizona.edu]

Amyotrophic Lateral Sclerosis Type 21

Collapse all Expand all Contexte La sclérose latérale amyotrophique, aussi connue sous le nom de « maladie du motoneurone », est une maladie neurodégénérative mortelle. Une insuffisance respiratoire neuromusculaire est la cause de décès la plus commune, généralement entre 2 et 5 ans après l'apparition de la maladie.[…] [cochranelibrary.com]

Ocular Myasthenia Gravis

Slight weakness in a limb may be tolerated, but slight weakness in the extraocular muscles would lead to misalignment of the two eyes, even a small degree of which could lead [en.wikipedia.org]

Extraocular Muscle Involvement Diplopia is very common in cases with OMG since even slight weakness of the EOMs causes symptomatic diplopia and since the EOMs do not adapt [ncbi.nlm.nih.gov]

Physiologic hypotheses propose that it is the unique structure and function of extraocular muscles that predispose them to weakness in MG. [en.wikipedia.org]

Neuromuscular Junction Disorder

Fixed extraocular muscle weakness may occur late in the illness, especially if untreated. Bulbar muscle weakness is next most common after extraocular weakness. [clinicalgate.com]

[…] causing ptosis or extraocular muscle weakness. [ahcmedia.com]

The presence of ptosis and extraocular muscle weakness that either fluctuates or does not conform to any pattern of ocular motor nerve paresis raises the suspicion of myasthenia [medtextfree.wordpress.com]

Chronic Progressive External Ophthalmoplegia

The most characteristic feature of the disease is extraocular muscle weakness leading to ptosis and limited eye movements. [symptoma.com]

In addition to extraocular muscle weakness, various other organs can typically be affected, including laryngeal and limb muscles, cerebrum, cerebellum, and peripheral nerves [ncbi.nlm.nih.gov]

Correcting myogenic ptosis accompanying extraocular muscle weakness: The "Bobby Pin" procedure Vemuri S, Christianson MD, Demirci H Orbit (Amsterdam, Netherlands), 2016, 35 [myobase.org]

Autosomal Dominant Progressive External Ophthalmoplegia Type 3

Mutations in the Twinkle gene, a cause of autosomal dominant progressive external ophthalmoplegia typically present with isolated extraocular muscle involvement. [annalsofian.org]

Progressive external ophthalmoplegia PEO is characterized by progressive weakness of the extraocular muscles causing ophthalmoparesis and ptosis 2,3,5. [radiopaedia.org]

Carcinomatous Myopathic Syndrome

Disease syndromes are characterized by muscle weakness, particularly extraocular muscles, with or without other neurological and metabolic disturbances. [somalidoc.com]

VI) Proximal Muscle Weakness Myasthenia gravis (autoimmune, voluntary muscle fatigue esp extraocular and cranial muscles, ptosis, diplopia, dysarthria, leg weakness, normal [med-ed.virginia.edu]

[…] often affects the extraocular and bulbar muscles and becomes worse with repetitive contraction. [itsmyositis.blogspot.com]

Oculomotor Nerve Paralysis

Patterns of extraocular muscle weakness in vasculopathic pupil-sparing, incomplete third nerve palsy. J Neuroophthalmol. 2001 Dec. 21 (4):256-9. [Medline]. [emedicine.com]

Myopathy with Abnormal Lipid Metabolism

Patients exhibit exercise intolerance, proximal or extraocular muscle weakness, myoclonus, salt craving, ataxia, sensorineural hearing loss, or peripheral neuropathy. [rheumaknowledgy.com]

Drug-Induced Myopathy

An approach to muscle weakness is presented in Figs. 195-1 and 195-2. FIGURE 195-1 Diagnostic evaluation of intermittent weakness. [accessmedicine.mhmedical.com]

Congenital Fibrosis of Extraocular Muscles Type 3A

Molecular pathology Defects of TUBB3 cause congenital fibrosis of extraocular muscles type 3A. [medical-dictionary.thefreedictionary.com]

MalaCards based summary : Fibrosis of Extraocular Muscles, Congenital, 3a, with or Without Extraocular Involvement, also known as fibrosis of extraocular muscles, congenital [malacards.org]

Acronym CFEOM3A Synonyms Congenital fibrosis of extraocular muscles 3A with or without extraocular involvement FEOM3 TUBB3 syndrome Any medical or genetic information present [uniprot.org]

Autosomal Recessive Inclusion Body Myopathy Type 2

[…] neuropathy Graves’ ophthalmopathy, extraocular muscle weakness Sarcoidosis myopathy Asymptomatic muscle involvement in ≤50% sarcoidosis patients Symmetrical proximal muscle [clevelandclinicmeded.com]

Juvenile Myasthenia Gravis

In ocular myasthenia gravis, muscle weakness often first appears in the muscles of the eyelids and other muscles that control movement of the eye (extraocular muscle). [mda.org]

Examinations show ptosis with mild extraocular muscle weakness; however, the baby experiences recurrent apneic episodes, which is considered as a hallmark of this disorder [intechopen.com]

Ptosis and extraocular muscle weakness are common presenting symptoms of juvenile myasthenia gravis and may be accompanied by, or progress to, generalized weakness. [thieme-connect.com]

Oculopharyngeal Muscular Dystrophy

muscle weakness, and proximal limb weakness. [eyerounds.org]

Correcting myogenic ptosis accompanying extraocular muscle weakness: The "Bobby Pin" procedure Vemuri S, Christianson MD, Demirci H Orbit (Amsterdam, Netherlands), 2016, 35 [myobase.org]

There is also often some element of extraocular muscle weakness (usually affecting supraduction), but complete external ophthalmoplegia is rare. [eyerounds.org]

Limb-Girdle Muscular Dystrophy Type 1F

May have muscle hypertrophy and distal muscle weakness. Extraocular muscle involvement has been reported in one case. [ 23 ] LGMD 1D-F Adulthood This is very rare. [patient.info]

Autosomal Dominant Progressive External Ophthalmoplegia Type 6

Mutations in the Twinkle gene, a cause of autosomal dominant progressive external ophthalmoplegia typically present with isolated extraocular muscle involvement. [annalsofian.org]

PEO is characterized by ptosis, impaired eye movements due to paralysis of the extraocular muscles (ophthalmoplegia), oropharyngeal weakness, and variably severe proximal [ncbi.nlm.nih.gov]

Myopathy, Endocrine

Disease syndromes are characterized by muscle weakness, particularly extraocular muscles, with or without other neurological and metabolic disturbances. [somalidoc.com]

Limb-Girdle Muscular Dystrophy Type 1E

Ophthalmoplegia totalis with Ptosis and Miosis

[…] eyelid ptosis and fixed or fluctuating extraocular muscle weakness are common presentations. [ncbi.nlm.nih.gov]

Later childhood-onset subtypes show abnormal muscle fatigability with difficulty in activities such as running or climbing stairs; motor milestones may be delayed; fluctuating [ncbi.nlm.nih.gov]

Myasthenia Gravis

Abstract Ocular myasthenia gravis, an autoimmune disease, is characterized by extraocular muscle weakness. [ncbi.nlm.nih.gov]

Typically, extraocular muscle weakness is asymmetric and can be noticed easily. [symptoma.com]

Typically, extraocular muscle weakness is asymmetric. [emedicine.medscape.com]

Mitochondrial Myopathy

On the other hand, Kearns-Sayre syndrome (KSS) is the most likely diagnosis with an early onset (< 20 years of age) of extraocular muscle weakness, pigmentary retinopathy, [symptoma.com]

Autosomal Recessive Progressive External Ophthalmoplegia

muscles. [uniprot.org]

Progressive external ophthalmoplegia PEO is characterized by progressive weakness of the extraocular muscles causing ophthalmoparesis and ptosis 2,3,5. [radiopaedia.org]

Weakness of extraocular muscle groups including, the orbicularis oculi muscle as well as facial and limb muscles may be present in up to 25% of patients with CPEO. [tisham-creativenest.blogspot.com]

Secondary Myopathy

Weakness affects most severely muscles that are innervated by brain stem nuclei, such as extraocular and facial muscles, and causes drooping of the eyelids, diplopia, and [neuropathology-web.org]

Congenital fibrosis of the extraocular muscles (static familial ophthalmoplegia) is an unusual condition, in which the myopathy is limited to the eyes (128). [neuroophthalmology.ca]

Lambert-Eaton Syndrome

At this point, none of the LEMS patients had weakness restricted to extraocular or bulbar muscles (p = 0.002). [jnnp.bmj.com]

In contrast, a significant portion of patients with MG never progress past weakness in the extraocular muscles. [emedicine.medscape.com]

Results: in myasthenia gravis, initial weakness involved extraocular muscles in 59%, bulbar muscles in 29%, and limb muscles in 12% of the patients. [rug.nl]

Autosomal Recessive Centronuclear Myopathy 5

Ptosis, extraocular muscle weakness and facial muscle involvement are frequently seen. [neurologyindia.com]

The majority of patients exhibit distal or proximal muscle weakness as a first symptom, presenting as general muscle weakness, eyelid drooping, extraocular muscle paralysis [spandidos-publications.com]

Discussion Centronuclear myopathy was first described in 1966. [6] It presents in early childhood with slowly progressive weakness of the extraocular, facial, neck, and limb [anesthesiology.pubs.asahq.org]

Absence or Deformity of Leg- Cataract Syndrome

Ptosis, extraocular muscle paresis and cranial nerve involvement is also common. [lecturio.com]

Limb-Girdle Muscular Dystrophy Type 2G

May have muscle hypertrophy and distal muscle weakness. Extraocular muscle involvement has been reported in one case. [ 23 ] LGMD 1D-F Adulthood This is very rare. [patient.info]

An additional atypical characteristic of LGMD2G, observed in this patient, was a subtle extraocular and facial weakness, since facial muscles were always spared in telethoninopathy [bmcclinpathol.biomedcentral.com]

Small hand muscle weakness was slight or inexistent in previously described patients [2]. [ncbi.nlm.nih.gov]