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17 Possible Causes for Extrapyramidal Symptoms - Later Onset

  • Hepatosplenomegaly

    Dementia and extrapyramidal signs are often seen later.[disorders.eyes.arizona.edu] However, there is considerable variation in onset and progression of disease but the symptoms are generally milder than that in types A and B.[disorders.eyes.arizona.edu]

  • Hallervorden-Spatz Syndrome

    These symptoms were much less common among patients who had the later-onset form of the disease or who did not have PANK2 mutations (P The predominant neurologic features[nejm.org] […] were extrapyramidal and included dystonia, dysarthria, rigidity, and choreoathetosis (51 of 52 patients [98 percent]).[nejm.org]

  • Niemann-Pick Disease Type C

    Dementia and extrapyramidal signs are often seen later.[disorders.eyes.arizona.edu] However, there is considerable variation in onset and progression of disease but the symptoms are generally milder than that in types A and B .[disorders.eyes.arizona.edu]

  • Leukodystrophy

    Some years later, extrapyramidal symptoms, cognitive impairment, nystagmus, dysarthria and pyramidal symptoms also developed.[ncbi.nlm.nih.gov] The patient's first symptoms appeared at the age of 18 years with behavioral changes and psychiatric problems.[ncbi.nlm.nih.gov] AARS2 gene (NM_020745.3) mutations result in two different phenotypic diseases: infantile mitochondrial cardiomyopathy and late-onset leukoencephalopathy.[ncbi.nlm.nih.gov]

  • Ataxia Telangiectasia

    Ataxia telangiectasia (A-T) typically presents with early-onset progressive cerebellar ataxia, oculomotor apraxia and later, oculo-cutaneous telangiectasia.[ncbi.nlm.nih.gov] Variant ataxia telangiectasia The presence of some residual ATM kinase activity relates to a less severe phenotype with later onset, often only in adulthood.[acnr.co.uk] Extrapyramidal symptoms, apart from chorea, are rare. In this paper, we report a case of A-T with an atypically mild and slowly progressive disease course.[ncbi.nlm.nih.gov]

  • Phakomatosis Pigmentokeratotica

    extrapyramidal symptoms Cardiomyopathy may develop with any type; ultimately fatal cutaneous: angiokeratoma corporis diffusum Unilateral nevoid telangiectasia rarely congenital[studyblue.com] […] in infancy or early childhood with more gradually progressive neurodegenerative disease Adult-onset form (type III) presents between 3 and 30 years of age w/ progressive[studyblue.com] […] neurodegenerative disease, coarse facies, corneal opacities, cherry-red spots on fundoscopy, hepatosplenomegaly, and dysostosis multiplex Late infantile/juvenile form (type II) presents later[studyblue.com]

  • Eng-Strom Syndrome

    These symptoms were much less common among patients who had the later-onset form of the disease or who did not have PANK2 mutations (P The predominant neurologic features[nejm.org] […] were extrapyramidal and included dystonia, dysarthria, rigidity, and choreoathetosis (51 of 52 patients [98 percent]).[nejm.org]

  • Tay-Sachs Disease

    Early symptoms may range from muscle weakness to extrapyramidal findings to altered cerebellar manifestations.[web.archive.org] These conditions represent a spectrum of later-onset, more slowly progressive neurodegenerative disorders, associated with low levels of residual HEX A enzyme activity.[web.archive.org]

  • Mitochondrial Membrane Protein-Associated Neurodegeneration

    Although the extrapyramidal syndrome associ-ated with MPAN is similar to that of PKAN, the age of onset ofMPAN is later and its expression of symptoms is milder [2].[docslide.net] These symptoms were much less common among patients who had the later-onset form of the disease or who did not have PANK2 mutations (P The predominant neurologic features[nejm.org] […] were extrapyramidal and included dystonia, dysarthria, rigidity, and choreoathetosis (51 of 52 patients [98 percent]).[nejm.org]

  • Rh Deficiency Syndrome

    These symptoms were much less common among patients who had the later-onset form of the disease or who did not have PANK2 mutations (P The predominant neurologic features[nejm.org] […] were extrapyramidal and included dystonia, dysarthria, rigidity, and choreoathetosis (51 of 52 patients [98 percent]).[nejm.org]

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