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423 Possible Causes for Extreme Clinical Heterogeneity

  • Glycogen Storage Disease Type 4

    Summary Clinical description Clinical presentation is extremely heterogeneous and involves the liver or the neuromuscular system.[orpha.net] The disease is extremely heterogeneous in terms of tissue involvement, age of onset and clinical manifestations.[ingentaconnect.com]

  • Vitamin D Deficiency

    Generalized convulsions in the afebrile infant represent a serious and etiopathogenically very heterogeneous problem.[ncbi.nlm.nih.gov] Extremely rare, as in the case of our patient, it may be due to severe hypocalcemia caused by a deficiency of vitamin D.[ncbi.nlm.nih.gov] […] given orally over a period of two weeks.The treatment resulted in complete stabilization of the infant's condition and rapid improvement in laboratory, radiological and clinical[ncbi.nlm.nih.gov]

  • Insomnia

    […] values were not available, to assess whether the missing data could have caused clinically relevant bias in the result.[doi.org] Assessment of heterogeneity We assessed clinical heterogeneity by noting the difference in the distribution of important participant factors between trials (age, gender, specific[doi.org] […] would impute the missing data as the most extreme values observed in the trial (also as best and worst‐case scenarios) or as two standard deviations away from the means if extreme[doi.org]

  • Insulin Resistance

    Furthermore, this report provides an additional example of a genetic condition presenting with clinical heterogeneity due to alternative transcript processing.[ncbi.nlm.nih.gov] In conclusion, POC1A mutations in exon 10 should be taken into account in patients with extreme insulin resistance and short stature.[ncbi.nlm.nih.gov]

  • Dermatitis

    We noted significant to extreme levels of unexplainable heterogeneity between the results of individual studies.[cochrane.org] The minimum clinically important difference for SCORAD has been estimated to be 8.7 points.[cochrane.org]

  • Fibroma

    Introduction Fibroma and giant-cell tumor (GCT) of the tendon sheath are lesions that occur typically in the extremities and belong to a heterogeneous group of fibrohistiocytic[dovepress.com] These lesions present similar clinical and histological features; however, researchers describe different views on the origin of these two entities.[dovepress.com]

  • Birth

    There are limited data for each subgroup, extremely high heterogeneity in one subgroup (91%), which could distort the interaction test and marginal differences in temperature[doi.org] We have very little confidence in the clinical relevance of this finding.[doi.org]

  • Puerperium

    There are limited data for each subgroup, extremely high heterogeneity in one subgroup (91%), which could distort the interaction test and marginal differences in temperature[doi.org] We have very little confidence in the clinical relevance of this finding.[doi.org]

  • Osteoarthritis

    However, we observed high heterogeneity (I² statistic 65%; Figure 6 ), and the right extreme of the 95% CI showed a clinical non‐relevant difference of effect.[doi.org]

  • Asthma

    A meta-analysis was not performed due to the extreme heterogeneity of the included studies.[doi.org] The extreme variability of the published RCTs in dosing and treatment schedules confounds meta-analysis.[doi.org] There was a wide range of clinical diversity in the types of participants, their allergies, allergens treated, and geographic treatment locations.[doi.org]

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