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418 Possible Causes for Extremity Ataxia, Fatigue, Progressive Polyneuropathy

  • Vitamin B12 Deficiency

    peripheral neuropathy, and spinal degeneration.[ncbi.nlm.nih.gov] In later stages, spasticity, extensor plantar responses, greater loss of position and vibratory sensation in the lower extremities, and ataxia emerge.[merckmanuals.com] The clinical symptoms are weakness, fatigue, shortness of breath and neurologic abnormalities.[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    Wernicke-Korsakoff syndrome (ataxia, confusion, ophthalmoplegia), amnesic problems, peripheral neuropathy and dementia.[patient.info] Chronic alcoholism can affect the circulatory system, increase the risk of anemia and lead to complaints like fatigue, breathlessness and lightheadedness .[epainassist.com] The most common symptoms of alcohol withdrawal include: Shakiness, tremors or Delirium tremens Anxiety Irritability Depression Fatigue Mood swings Bad dreams or nightmares[addictions.com]

  • Vasculitis

    Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[neuromuscular.wustl.edu] Aspects of disease relevant for AAV patients were: fatigue and lack of energy; visual abnormalities; neuropathy; renal impairment; arthritis, and sinusitis.[ncbi.nlm.nih.gov] Accompanying neck pain was present, together with continuous lethargy and fatigue.[ncbi.nlm.nih.gov]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[ncbi.nlm.nih.gov] On admission, the patient exhibited bifacial, extremity weakness, ataxia, impaired sensation, and areflexia. Electrophysiology and nerve biopsy suggested demyelination.[ncbi.nlm.nih.gov] We present a patient with CIDP in whom fatigue remained the only symptom, hereby stressing the importance of adding this disease to the differential diagnosis of fatigue.[ncbi.nlm.nih.gov]

  • Paraneoplastic Syndrome

    We report a fatal case of severe chronic progressive axonal polyradiculoneuropathy in association with this antibody.[doi.org] Cerebellar symptoms : ataxia, unsteady gait, dysdiadochokinesia, intention tremor Note that symptoms often emerge months before the discovery of a primary tumor ![amboss.com] The authors present a case report of a woman with presumed contact dermatitis who was diagnosed with breast cancer in the setting of progressive fatigue and muscle weakness[ncbi.nlm.nih.gov]

  • Thiamine Deficiency

    […] voice, inattention, ataxia, and binocular diplopia after a voluntary 59-kg weight loss over 5 months.[ncbi.nlm.nih.gov] […] about thiamine and thyroid fatigue.[thyroidpharmacist.com] After 2 to 3 months apathy and weakness become extreme, calf muscle tenderness develops with loss of recent memory, confusion, ataxia, and sometimes persistent vomiting ([wardelab.com]

  • Subacute Combined Degeneration of Spinal Cord

    Case Presentation: A 28‐year‐old nursing student with a history of bipolar disorder presented to Tucson Medical Center with symptoms of ataxia and bilateral lower‐extremity[shmabstracts.com] We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: May 13, 2019[patientslikeme.com] He presented acutely with tremors, diaphoresis, insomnia, ataxia (progressive over the last three months), lower extremity paresthesias, decreased somatosensory perception[em-consulte.com]

  • Heavy Metal Poisoning

    In addition, non-inflammatory degenerative disease of the sensorimotor nerves (sensorimotor polyneuropathy) may advance to progressive deterioration (atrophy).[rarediseases.org] Local villagers ate the fish and began to exhibit signs of neurologic damage, such as visual loss, extremity numbness, hearing loss, and ataxia.[slideshare.net] This model gives greater insight into how the body responds throughout the stages of adrenal fatigue.[drlam.com]

  • Pernicious Anemia

    We describe a case of a young black woman with gradually progressive lower extremity paresthesias, weakness, and ataxia as the primary presenting symptoms of pernicious anemia[ncbi.nlm.nih.gov] Signs and Symptoms of Anemia The most common symptom of all types of anemia is fatigue (tiredness).[web.archive.org] ), ataxia and positive Babinski reflexes.[doi.org]

  • Guillain-Barré Syndrome

    Guillain-Barré syndrome is a rare condition in pregnancy which is characterised by symmetrical progressive ascending polyneuropathy.[ncbi.nlm.nih.gov] , and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk.[icd10data.com] Guillain-Barré syndrome (GBS) encompasses a broad spectrum of health-related quality of life (HRQL) determinants, including mobility, fatigue, pain, and depression.[ncbi.nlm.nih.gov]

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