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230 Possible Causes for Extremity Ataxia, Hepatomegaly, Progressive Polyneuropathy

  • Chronic Alcoholism

    Hepatomegaly (in chronic alcoholic liver disease the liver is shrunken). Ascites; gonadal atrophy. Atrial fibrillation and cardiomyopathy.[patient.info] Characteristic ultrasonographic findings include a hyperechoic liver with or without hepatomegaly.[clevelandclinicmeded.com] Most patients with moderate disease are undernourished and present with fatigue, fever, jaundice, right upper quadrant pain, tender hepatomegaly, and sometimes a hepatic bruit[merckmanuals.com]

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] We describe a case of a young black woman with gradually progressive lower extremity paresthesias, weakness, and ataxia as the primary presenting symptoms of pernicious anemia[ncbi.nlm.nih.gov] Hepatomegaly and splenomegaly may be present.[patient.info]

  • Vitamin B12 Deficiency

    […] names or words Radiculopathy - chronic pain disorder Increased susceptibility to infections Poor wound healing Malnutrition Enlarged spleen (splenomegaly) Enlarged liver (hepatomegaly[b12deficiency.info] peripheral neuropathy, and spinal degeneration.[ncbi.nlm.nih.gov] In later stages, spasticity, extensor plantar responses, greater loss of position and vibratory sensation in the lower extremities, and ataxia emerge.[merckmanuals.com]

  • POEMS Syndrome

    Hepatomegaly was significantly reduced after the completion of BorCyDex.[ncbi.nlm.nih.gov] Before the implementation of aPBSCT, the clinical course of POEMS syndrome was characterized by progressive polyneuropathy potentially leading to death for respiratory failure[ncbi.nlm.nih.gov] Neurologic examination revealed upper and lower extremity weakness with bilateral foot drop and gait ataxia requiring crutches for ambulation and bilateral foot braces.[nature.com]

  • Vasculitis

    In addition to the classical ones, KD may be manifested through a wide variety of symptoms including diarrhoea, hepatomegaly, jaundice, arthritis, myocarditis, pericarditis[elsevier.es] Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[neuromuscular.wustl.edu] CRYOGLOBULINEMIA (CRYOGLOBULINEMIA WITH VASCULITIS) Type II mixed cryoglobulinemia (MC) is characterized by recurrent purpura, arthralgias / arthritis, weakness, peripheral neuropathy, hepatomegaly[lupusinternational.com]

  • Thiamine Deficiency

    Physical examination: pallor, tachycardia, hepatomegaly.[ncbi.nlm.nih.gov] Nerve conduction studies were consistent with axonal, length-dependent polyneuropathy.[ncbi.nlm.nih.gov] After 2 to 3 months apathy and weakness become extreme, calf muscle tenderness develops with loss of recent memory, confusion, ataxia, and sometimes persistent vomiting ([wardelab.com]

  • Arsenic-Induced Polyneuropathy

    Our interest in the problem arose because we observed some patients, who were opium addicts, having a clinical picture of arsenical neuropathy * and hepatomegaly.[unodc.org] ., sensory ataxia due to vitamin B 12 deficiency) Deep tendon reflexes References: [10] [11] [12] [9] Subtypes and variants Diabetic polyneuropathy Definition : progressive[amboss.com] […] jerks, tremors, seizures, an impaired ability to coordinate voluntary movements (ataxia), and/or inability to stand or walk.[rarediseases.org]

  • Castleman Disease

    Examination revealed pallor; generalized edema; axillary, cervical, and inguinal lymphadenopathy; hypertension; and hepatomegaly.[ncbi.nlm.nih.gov] Progressive motor polyneuropathy suggesting coexistent POEMS does not respond well to rituximab or to IL-6–targeted therapy, and these patients require autologous stem cell[hematology.org] […] in association with a total ophtalmoplegia and a dysphagia, consistent with the Miller-Fisher syndrome (ophtalmoplegia, ataxia, and areflexia).[karger.com]

  • Polyneuropathy

    While about 20% of patients will have hepatomegaly, 75% will have hepatic granulomas.[cjasn.asnjournals.org] Convert to ICD-10-CM : 356.4 converts directly to: 2015/16 ICD-10-CM G60.3 Idiopathic progressive neuropathy Approximate Synonyms Idiopathic progressive neuropathy Polyneuropathy[icd9data.com] There are only sensory symptoms, e.g. sensory ataxia, numbness and pain.[nnjournal.net]

  • Familial Progressive Polyneuropathy

    While about 20% of patients will have hepatomegaly, 75% will have hepatic granulomas.[cjasn.asnjournals.org] Abstract The purpose of this study was to evaluate the clinical and pathological features in patients with progressive-type familial amyloidotic polyneuropathy (FAP) using[ncbi.nlm.nih.gov] […] with marked disturbances of sensation and ataxia of movement and caused by an interstitial hypertrophic neuritis that ascends with consecutive medullary [cord] lesions.[karger.com]

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