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131 Possible Causes for Extremity Ataxia, Macrocytic Anemia, Progressive Polyneuropathy

  • Vitamin B12 Deficiency

    peripheral neuropathy, and spinal degeneration.[ncbi.nlm.nih.gov] In later stages, spasticity, extensor plantar responses, greater loss of position and vibratory sensation in the lower extremities, and ataxia emerge.[merckmanuals.com] Macrocytic anemias are generally classified into megaloblastic or nonmegaloblastic anemia.[doi.org]

  • Chronic Alcoholism

    Wernicke-Korsakoff syndrome (ataxia, confusion, ophthalmoplegia), amnesic problems, peripheral neuropathy and dementia.[patient.info] Macrocytosis with an MCV 100 fL reflects the direct effect of alcohol on bone marrow as well as macrocytic anemia resulting from folate deficiency, which is common among undernourished[merckmanuals.com] Other diseases include scurvy , resulting from vitamin C deficiency; hypochromic macrocytic anemia, caused by folate deficiency, vitamin B 12 deficiency, or certain chemotherapeutic[britannica.com]

  • Pernicious Anemia

    We describe a case of a young black woman with gradually progressive lower extremity paresthesias, weakness, and ataxia as the primary presenting symptoms of pernicious anemia[ncbi.nlm.nih.gov] Macrocytic anemia incidiously appeared in September 1999.[ncbi.nlm.nih.gov] ), ataxia and positive Babinski reflexes.[doi.org]

  • Subacute Combined Degeneration of Spinal Cord

    Case Presentation: A 28‐year‐old nursing student with a history of bipolar disorder presented to Tucson Medical Center with symptoms of ataxia and bilateral lower‐extremity[shmabstracts.com] Serum B12, methylmalonic acid, Schilling test, Complete Blood Count- looking for megaloblastic anemia if there is also folic acid deficiency or macrocytic anemia.[en.wikipedia.org] He presented acutely with tremors, diaphoresis, insomnia, ataxia (progressive over the last three months), lower extremity paresthesias, decreased somatosensory perception[em-consulte.com]

  • Heavy Metal Poisoning

    In addition, non-inflammatory degenerative disease of the sensorimotor nerves (sensorimotor polyneuropathy) may advance to progressive deterioration (atrophy).[rarediseases.org] Local villagers ate the fish and began to exhibit signs of neurologic damage, such as visual loss, extremity numbness, hearing loss, and ataxia.[slideshare.net] Arsenic Useful lab tests include Urinalysis ( Oliguria, Hematuria, Hemoglobinuria); Complete Blood Count and Peripheral Smear (Macrocytic Anemia ); Tissue Exam (reveals arsenic[diagnose-me.com]

  • Familial Progressive Polyneuropathy

    Abstract The purpose of this study was to evaluate the clinical and pathological features in patients with progressive-type familial amyloidotic polyneuropathy (FAP) using[ncbi.nlm.nih.gov] […] with marked disturbances of sensation and ataxia of movement and caused by an interstitial hypertrophic neuritis that ascends with consecutive medullary [cord] lesions.[karger.com] Hematological abnormalities, including hypersegmentation of polymorphonuclear cells and a macrocytic anemia, can be seen; however, they may be completely absent at the time[neuroweb.us]

  • Thiamine Deficiency

    Nerve conduction studies were consistent with axonal, length-dependent polyneuropathy.[ncbi.nlm.nih.gov] […] red cells with or without anemia, presence of hypersegmented neutrophils, and occasionally pancytopenia.[web.archive.org] After 2 to 3 months apathy and weakness become extreme, calf muscle tenderness develops with loss of recent memory, confusion, ataxia, and sometimes persistent vomiting ([wardelab.com]

  • Arsenic-Induced Polyneuropathy

    ., sensory ataxia due to vitamin B 12 deficiency) Deep tendon reflexes References: [10] [11] [12] [9] Subtypes and variants Diabetic polyneuropathy Definition : progressive[amboss.com] […] jerks, tremors, seizures, an impaired ability to coordinate voluntary movements (ataxia), and/or inability to stand or walk.[rarediseases.org] (normocytic or macrocytic) with coarse basophilic stippling and karyorrhexis ( N Engl J Med 1965;273:18, West J Med 1983;139:219, Am J Clin Pathol 1984;81:533, Blut 1985;[pathologyoutlines.com]

  • Transcobalamin 2 Deficiency

    In later stages, spasticity, extensor plantar responses, greater loss of position and vibratory sensation in the lower extremities, and ataxia emerge.[merckmanuals.com] Complete blood count revealed severe macrocytic anemia (hemoglobin, 2.8 g/dL; mean corpuscular volume, 117 fL), thrombocytopenia (platelets, 117 10 9/L), and normal white[imagebank.hematology.org] peripheral neuropathy with pronounced anemia, Spinal degeneration, Brain atrophy, and macrocytic cells.[vitaminb12deficiency.net.au]

  • Hereditary Orotic Aciduria

    Clinical features Ataxia, chorea, and axonal polyneuropathy Cutaneous photosensitivity and multiple cancers Mental and motor retardation Microcephaly Sensorineural deafness[emedicine.medscape.com] TOC HEME Approach to Macrocytic /Megaloblastic Anemia By means of morphologic and biochemical criteria, macrocytic anemias can be divided into two groups: The megaloblastic[enotes.tripod.com] It includes signs and symptoms of macrocytic hypochromic anemia with megaloblastic changes in bone marrow, leukopenia, retarded growth, and urinary excretion of large amounts[medical-dictionary.thefreedictionary.com]

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